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Acsl3 acyl-CoA synthetase long-chain family member 3 [ Mus musculus (house mouse) ]

Gene ID: 74205, updated on 5-Feb-2023

Summary

Official Symbol
Acsl3provided by MGI
Official Full Name
acyl-CoA synthetase long-chain family member 3provided by MGI
Primary source
MGI:MGI:1921455
See related
Ensembl:ENSMUSG00000032883 AllianceGenome:MGI:1921455
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Acs3; Facl3; LACS 3; Pro2194; 2610510B12Rik
Summary
Predicted to enable arachidonate-CoA ligase activity; protein domain specific binding activity; and protein kinase binding activity. Predicted to be involved in several processes, including fatty acid metabolic process; positive regulation of phosphatidylcholine biosynthetic process; and positive regulation of transport. Predicted to act upstream of or within fatty acid metabolic process. Predicted to be located in Golgi apparatus and perinuclear region of cytoplasm. Predicted to be active in endoplasmic reticulum; lipid droplet; and plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in asthma; breast cancer; and prostate cancer. Orthologous to human ACSL3 (acyl-CoA synthetase long chain family member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cortex adult (RPKM 21.5), frontal lobe adult (RPKM 18.3) and 25 other tissues See more
Orthologs
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Genomic context

See Acsl3 in Genome Data Viewer
Location:
1 C4; 1 40.84 cM
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (78635542..78685460)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (78657825..78707743)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene monoacylglycerol O-acyltransferase 1 Neighboring gene predicted gene, 39665 Neighboring gene RIKEN cDNA 5730419F03 gene Neighboring gene U6 spliceosomal RNA Neighboring gene UTP14B small subunit processome component Neighboring gene predicted gene, 51635 Neighboring gene predicted gene, 38631 Neighboring gene predicted gene, 33693 Neighboring gene heterogeneous nuclear ribonucleoprotein R pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3) 
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables arachidonate-CoA ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables butyrate-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables long-chain fatty acid-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables long-chain fatty acid-CoA ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables medium-chain fatty acid-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 
is_active_in lipid droplet IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in lipid droplet ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
fatty acid CoA ligase Acsl3
Names
arachidonate--CoA ligase
fatty acid Coenzyme A ligase, long chain 3
long-chain acyl-CoA synthetase 3
long-chain-fatty-acid--CoA ligase 3
medium-chain acyl-CoA ligase Acsl3
NP_001028778.2
NP_001129694.1
NP_083093.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033606.3NP_001028778.2  fatty acid CoA ligase Acsl3 isoform a

    See identical proteins and their annotated locations for NP_001028778.2

    Status: VALIDATED

    Source sequence(s)
    AC156613
    Consensus CDS
    CCDS15087.1
    UniProtKB/Swiss-Prot
    Q8K1J7, Q9CZW4
    Related
    ENSMUSP00000121695.2, ENSMUST00000142704.8
    Conserved Domains (1) summary
    PLN02387
    Location:30717
    PLN02387; long-chain-fatty-acid-CoA ligase family protein
  2. NM_001136222.2NP_001129694.1  fatty acid CoA ligase Acsl3 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC156613
    Consensus CDS
    CCDS48295.1
    UniProtKB/Swiss-Prot
    Q9CZW4
    UniProtKB/TrEMBL
    E9PUC2
    Related
    ENSMUSP00000117952.2, ENSMUST00000134566.8
    Conserved Domains (1) summary
    cd05927
    Location:2565
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
  3. NM_001409075.1NP_001396004.1  fatty acid CoA ligase Acsl3 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC156613
  4. NM_001409076.1NP_001396005.1  fatty acid CoA ligase Acsl3 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC156613
  5. NM_001409077.1NP_001396006.1  fatty acid CoA ligase Acsl3 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC156613
    UniProtKB/Swiss-Prot
    Q8K1J7
  6. NM_001409078.1NP_001396007.1  fatty acid CoA ligase Acsl3 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC156613
    UniProtKB/Swiss-Prot
    Q8K1J7
  7. NM_001409079.1NP_001396008.1  fatty acid CoA ligase Acsl3 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC156613
    UniProtKB/TrEMBL
    E9PUC2
  8. NM_028817.4NP_083093.2  fatty acid CoA ligase Acsl3 isoform a

    See identical proteins and their annotated locations for NP_083093.2

    Status: VALIDATED

    Source sequence(s)
    AC156613
    Consensus CDS
    CCDS15087.1
    UniProtKB/Swiss-Prot
    Q8K1J7, Q9CZW4
    Related
    ENSMUSP00000045291.9, ENSMUST00000035779.15
    Conserved Domains (1) summary
    PLN02387
    Location:30717
    PLN02387; long-chain-fatty-acid-CoA ligase family protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    78635542..78685460
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)