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Cep97 centrosomal protein 97 [ Mus musculus (house mouse) ]

Gene ID: 74201, updated on 12-May-2024

Summary

Official Symbol
Cep97provided by MGI
Official Full Name
centrosomal protein 97provided by MGI
Primary source
MGI:MGI:1921451
See related
Ensembl:ENSMUSG00000022604 AllianceGenome:MGI:1921451
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lrriq2; 2810403B08Rik; 4932439K18Rik; E130116N02Rik
Summary
Involved in negative regulation of cilium assembly. Predicted to be located in centriolar satellite and cytosol. Predicted to be part of protein-containing complex. Is expressed in several structures, including intestine; male reproductive gland or organ; nervous system; thymus; and urinary system. Orthologous to human CEP97 (centrosomal protein 97). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 3.3), CNS E11.5 (RPKM 2.9) and 21 other tissues See more
Orthologs
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Genomic context

See Cep97 in Genome Data Viewer
Location:
16 C1.1; 16 33.69 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (55720250..55755237, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (55899888..55934848, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene neurexophilin and PC-esterase domain family, member 3 Neighboring gene adaptor-related protein complex 3, sigma 1 subunit pseudogene Neighboring gene conserved helix-loop-helix ubiquitous kinase pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7464 Neighboring gene STARR-positive B cell enhancer ABC_E7465 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:55949146-55949379 Neighboring gene ribosomal protein L11 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E4179 Neighboring gene STARR-seq mESC enhancer starr_41049 Neighboring gene STARR-seq mESC enhancer starr_41050 Neighboring gene predicted gene 6958

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell projection organization IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of cilium assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cilium assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of mitotic spindle assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in centriole ISO
Inferred from Sequence Orthology
more info
 
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
centrosomal protein of 97 kDa
Names
leucine-rich repeat and IQ domain-containing protein 2
leucine-rich repeats and IQ motif containing 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159364.1NP_001152836.1  centrosomal protein of 97 kDa isoform 2

    See identical proteins and their annotated locations for NP_001152836.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    BC065773, BC067049
    Consensus CDS
    CCDS49871.1
    UniProtKB/TrEMBL
    Q6P077
    Related
    ENSMUSP00000113009.2, ENSMUST00000122280.8
    Conserved Domains (3) summary
    sd00033
    Location:4059
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:103144
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:80136
    LRR_8; Leucine rich repeat
  2. NM_001159365.1NP_001152837.1  centrosomal protein of 97 kDa isoform 3

    See identical proteins and their annotated locations for NP_001152837.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK079884, BC065773, BC067049
    Consensus CDS
    CCDS49873.1
    UniProtKB/TrEMBL
    Q8BH46
    Related
    ENSMUSP00000112502.2, ENSMUST00000121129.8
    Conserved Domains (3) summary
    sd00033
    Location:4059
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:103144
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:80136
    LRR_8; Leucine rich repeat
  3. NM_001159366.1NP_001152838.1  centrosomal protein of 97 kDa isoform 4

    See identical proteins and their annotated locations for NP_001152838.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK080249, BC065773, BC067049
    Consensus CDS
    CCDS49872.1
    UniProtKB/TrEMBL
    Q8BJR7
    Related
    ENSMUSP00000113470.3, ENSMUST00000121703.3
    Conserved Domains (3) summary
    sd00033
    Location:4059
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:103144
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:80136
    LRR_8; Leucine rich repeat
  4. NM_028815.4NP_083091.1  centrosomal protein of 97 kDa isoform 1

    See identical proteins and their annotated locations for NP_083091.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC165151, AC171202, BC067049
    Consensus CDS
    CCDS28217.1
    UniProtKB/Swiss-Prot
    Q8BL35, Q9CZ62
    Related
    ENSMUSP00000023270.8, ENSMUST00000023270.14
    Conserved Domains (3) summary
    sd00033
    Location:1737
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:103144
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:80136
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    55720250..55755237 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_004939252.1 RNA Sequence