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Rnd3 Rho family GTPase 3 [ Mus musculus (house mouse) ]

Gene ID: 74194, updated on 13-Dec-2022

Summary

Official Symbol
Rnd3provided by MGI
Official Full Name
Rho family GTPase 3provided by MGI
Primary source
MGI:MGI:1921444
See related
Ensembl:ENSMUSG00000017144 AllianceGenome:MGI:1921444
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Arhe; Rhoe; 2610017M01Rik
Summary
Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Predicted to be involved in several processes, including cytoskeleton organization; regulation of actin cytoskeleton organization; and regulation of cell shape. Predicted to be located in Golgi apparatus and membrane. Predicted to be active in several cellular components, including cell cortex; cytoplasmic vesicle; and cytoskeleton. Is expressed in central nervous system; genitourinary system; retina; and vascular system. Orthologous to human RND3 (Rho family GTPase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E11.5 (RPKM 46.9), whole brain E14.5 (RPKM 28.6) and 11 other tissues See more
Orthologs
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Genomic context

See Rnd3 in Genome Data Viewer
Location:
2; 2 C1.1
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (51020451..51039123, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (51130439..51149111, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 39811 Neighboring gene heat shock protein 90 alpha (cytosolic), class B member 1 pseudogene Neighboring gene predicted gene, 32360 Neighboring gene pyrophosphatase (inorganic) 1 pseudogene Neighboring gene predicted gene 13497

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
rho-related GTP-binding protein RhoE
Names
ras homolog gene family, member E

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028810.2NP_083086.1  rho-related GTP-binding protein RhoE

    See identical proteins and their annotated locations for NP_083086.1

    Status: PROVISIONAL

    Source sequence(s)
    AL844893
    Consensus CDS
    CCDS16028.1
    UniProtKB/Swiss-Prot
    P61588, Q6ZWS2
    UniProtKB/TrEMBL
    A0A6P5NVB3, A0A8C6GWX5
    Related
    ENSMUSP00000017288.3, ENSMUST00000017288.9
    Conserved Domains (1) summary
    cd04172
    Location:19200
    Rnd3_RhoE_Rho8; Rnd3/RhoE/Rho8 GTPases

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    51020451..51039123 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)