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Katnb1 katanin p80 (WD40-containing) subunit B 1 [ Mus musculus (house mouse) ]

Gene ID: 74187, updated on 12-May-2024

Summary

Official Symbol
Katnb1provided by MGI
Official Full Name
katanin p80 (WD40-containing) subunit B 1provided by MGI
Primary source
MGI:MGI:1921437
See related
Ensembl:ENSMUSG00000031787 AllianceGenome:MGI:1921437
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KAT; 2410003J24Rik
Summary
Enables dynein complex binding activity. Predicted to be involved in several processes, including microtubule cytoskeleton organization; positive regulation of neuron projection development; and regulation of microtubule depolymerization. Predicted to act upstream of or within cell division. Located in axon and centrosome. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and primitive streak. Human ortholog(s) of this gene implicated in lissencephaly 6. Orthologous to human KATNB1 (katanin regulatory subunit B1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 79.1), whole brain E14.5 (RPKM 14.9) and 25 other tissues See more
Orthologs
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Genomic context

See Katnb1 in Genome Data Viewer
Location:
8 C5; 8 47.12 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (95807804..95826502)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (95081175..95099874)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 51544 Neighboring gene adhesion G protein-coupled receptor G3 Neighboring gene dynein regulatory complex subunit 7 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:97604749-97604932 Neighboring gene kinesin family member C3 Neighboring gene predicted gene, 31224 Neighboring gene STARR-seq mESC enhancer starr_22375 Neighboring gene predicted gene, 31036

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1)  1 citation
  • Endonuclease-mediated (3) 
  • Targeted (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATPase regulator activity ISO
Inferred from Sequence Orthology
more info
 
enables dynein complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in microtubule depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in microtubule severing ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of microtubule depolymerization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of microtubule depolymerization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in growth cone ISO
Inferred from Sequence Orthology
more info
 
part_of katanin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of katanin complex ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in midbody ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in spindle ISO
Inferred from Sequence Orthology
more info
 
located_in spindle pole ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
katanin p80 WD40 repeat-containing subunit B1
Names
katanin p80 subunit B1
p80 katanin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028805.2NP_083081.2  katanin p80 WD40 repeat-containing subunit B1

    See identical proteins and their annotated locations for NP_083081.2

    Status: VALIDATED

    Source sequence(s)
    AK031630, AK034103, AK136322, BB842538
    Consensus CDS
    CCDS22555.1
    UniProtKB/Swiss-Prot
    Q8BG40, Q8CD18, Q8R1J0, Q9CWV2
    Related
    ENSMUSP00000034239.8, ENSMUST00000034239.9
    Conserved Domains (4) summary
    cd00200
    Location:7257
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:67103
    7WD40; WD40 repeat [structural motif]
    pfam02063
    Location:367465
    MARCKS; MARCKS family
    pfam13925
    Location:500651
    Katanin_con80; con80 domain of Katanin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    95807804..95826502
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531411.5XP_006531474.1  katanin p80 WD40 repeat-containing subunit B1 isoform X1

    See identical proteins and their annotated locations for XP_006531474.1

    UniProtKB/Swiss-Prot
    Q8BG40, Q8CD18, Q8R1J0, Q9CWV2
    Conserved Domains (4) summary
    cd00200
    Location:7257
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:67103
    7WD40; WD40 repeat [structural motif]
    pfam02063
    Location:367465
    MARCKS; MARCKS family
    pfam13925
    Location:500651
    Katanin_con80; con80 domain of Katanin
  2. XM_006531412.1XP_006531475.1  katanin p80 WD40 repeat-containing subunit B1 isoform X1

    See identical proteins and their annotated locations for XP_006531475.1

    UniProtKB/Swiss-Prot
    Q8BG40, Q8CD18, Q8R1J0, Q9CWV2
    Conserved Domains (4) summary
    cd00200
    Location:7257
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:67103
    7WD40; WD40 repeat [structural motif]
    pfam02063
    Location:367465
    MARCKS; MARCKS family
    pfam13925
    Location:500651
    Katanin_con80; con80 domain of Katanin
  3. XM_006531410.4XP_006531473.1  katanin p80 WD40 repeat-containing subunit B1 isoform X1

    See identical proteins and their annotated locations for XP_006531473.1

    UniProtKB/Swiss-Prot
    Q8BG40, Q8CD18, Q8R1J0, Q9CWV2
    Conserved Domains (4) summary
    cd00200
    Location:7257
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:67103
    7WD40; WD40 repeat [structural motif]
    pfam02063
    Location:367465
    MARCKS; MARCKS family
    pfam13925
    Location:500651
    Katanin_con80; con80 domain of Katanin

RNA

  1. XR_001778484.2 RNA Sequence

  2. XR_387781.4 RNA Sequence

  3. XR_001778483.2 RNA Sequence