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Cmtr1 cap methyltransferase 1 [ Mus musculus (house mouse) ]

Gene ID: 74157, updated on 12-May-2024

Summary

Official Symbol
Cmtr1provided by MGI
Official Full Name
cap methyltransferase 1provided by MGI
Primary source
MGI:MGI:1921407
See related
Ensembl:ENSMUSG00000024019 AllianceGenome:MGI:1921407
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MTr1; Ftsjd2; 1300018I05Rik
Summary
Predicted to enable mRNA (nucleoside-2'-O-)-methyltransferase activity. Predicted to be involved in 7-methylguanosine mRNA capping and cap1 mRNA methylation. Predicted to act upstream of or within mRNA processing. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in central nervous system; olfactory epithelium; and retina. Orthologous to human CMTR1 (cap methyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 14.8), CNS E14 (RPKM 12.4) and 28 other tissues See more
Orthologs
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Genomic context

See Cmtr1 in Genome Data Viewer
Location:
17 A3.3; 17 15.43 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (29879569..29924953)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (29660595..29705979)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7509 Neighboring gene predicted gene, 28043 Neighboring gene ring finger protein 8 Neighboring gene predicted gene, 20161 Neighboring gene STARR-positive B cell enhancer ABC_E1501 Neighboring gene coiled-coil domain containing 167 Neighboring gene STARR-positive B cell enhancer ABC_E7510 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:29906709-29906939 Neighboring gene STARR-positive B cell enhancer mm9_chr17:29978669-29978970 Neighboring gene STARR-seq mESC enhancer starr_42296 Neighboring gene STARR-seq mESC enhancer starr_42297 Neighboring gene MAM domain containing glycosylphosphatidylinositol anchor 1 Neighboring gene STARR-seq mESC enhancer starr_42299 Neighboring gene predicted gene, 41559 Neighboring gene STARR-seq mESC enhancer starr_42301 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:30116968-30117151 Neighboring gene predicted gene, 22327

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough Gm28043

Readthrough gene: Gm28043, Included gene: Rnf8

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables mRNA (nucleoside-2'-O-)-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables mRNA (nucleoside-2'-O-)-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in 7-methylguanosine mRNA capping IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in 7-methylguanosine mRNA capping ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
 
involved_in methylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
Names
FtsJ methyltransferase domain-containing protein 2
S-adenosyl-L-methionine-dependent methyltransferase FTSJD2
cap1 2'O-ribose methyltransferase 1
NP_083067.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028791.6NP_083067.1  cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1

    See identical proteins and their annotated locations for NP_083067.1

    Status: VALIDATED

    Source sequence(s)
    AK005044, AK080379, AW050293, BC056481, BC080305, BY290726, CF746189
    Consensus CDS
    CCDS37539.1
    UniProtKB/Swiss-Prot
    Q3U3G5, Q3U7Y9, Q6A0D5, Q8C7V0, Q9DBC3
    UniProtKB/TrEMBL
    A0A3Q4EHZ1
    Related
    ENSMUSP00000024816.7, ENSMUST00000024816.13
    Conserved Domains (3) summary
    pfam01585
    Location:86128
    G-patch; G-patch domain
    pfam01728
    Location:231447
    FtsJ; FtsJ-like methyltransferase
    cl12015
    Location:622739
    Adenylation_DNA_ligase_like; Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    29879569..29924953
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)