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Unkl unkempt family like zinc finger [ Mus musculus (house mouse) ]

Gene ID: 74154, updated on 26-Sep-2022

Summary

Official Symbol
Unklprovided by MGI
Official Full Name
unkempt family like zinc fingerprovided by MGI
Primary source
MGI:MGI:1921404
See related
Ensembl:ENSMUSG00000015127 AllianceGenome:MGI:1921404
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1300004G08Rik
Summary
Predicted to enable metal ion binding activity and transferase activity. Predicted to be located in cytosol. Is expressed in ganglia and liver lobe. Orthologous to human UNKL (unk like zinc finger). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 12.9), liver E14.5 (RPKM 10.6) and 28 other tissues See more
Orthologs
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Genomic context

See Unkl in Genome Data Viewer
Location:
17; 17 A3.3
Exon count:
21
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (25407336..25453417)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (25188361..25234443)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene intestine-critical region regulatory element Neighboring gene proline and glutamate rich with coiled coil 1 Neighboring gene ubiquinol-cytochrome c reductase complex assembly factor 4 Neighboring gene predicted gene, 52286 Neighboring gene N-acetylglucosamine-1-phosphotransferase, gamma subunit Neighboring gene TSR3 20S rRNA accumulation Neighboring gene BAI1-associated protein 3 Neighboring gene microRNA 3547

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC102273

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
putative E3 ubiquitin-protein ligase UNKL

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001197024.1NP_001183953.1  putative E3 ubiquitin-protein ligase UNKL isoform 1

    See identical proteins and their annotated locations for NP_001183953.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest protein (isoform 1).
    Source sequence(s)
    AK004898, BC059910, CJ068427
    Consensus CDS
    CCDS57058.1
    UniProtKB/Swiss-Prot
    Q5FWH2, Q9DBK4
    Related
    ENSMUSP00000039670.6, ENSMUST00000039734.12
    Conserved Domains (3) summary
    pfam00642
    Location:286310
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam13863
    Location:564638
    DUF4200; Domain of unknown function (DUF4200)
    pfam13920
    Location:684721
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
  2. NM_001290736.1NP_001277665.1  putative E3 ubiquitin-protein ligase UNKL isoform 3

    See identical proteins and their annotated locations for NP_001277665.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon compared to variant 1. The encoded protein (isoform 3) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC130711, BC059910
    Consensus CDS
    CCDS70769.1
    UniProtKB/TrEMBL
    E0CYD7
    Related
    ENSMUSP00000124276.2, ENSMUST00000160896.8
    Conserved Domains (3) summary
    pfam00642
    Location:100124
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    cl17238
    Location:498535
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    cl26597
    Location:387448
    DUF2058; Uncharacterized protein conserved in bacteria (DUF2058)
  3. NM_001357876.1NP_001344805.1  putative E3 ubiquitin-protein ligase UNKL isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC130711
    Conserved Domains (3) summary
    pfam00642
    Location:286310
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    cl17238
    Location:608645
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    cl27210
    Location:495563
    Mnd1; Mnd1 family
  4. NM_001357877.1NP_001344806.1  putative E3 ubiquitin-protein ligase UNKL isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC130711
    Consensus CDS
    CCDS70769.1
    UniProtKB/TrEMBL
    E0CYD7
    Conserved Domains (3) summary
    pfam00642
    Location:100124
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    cl17238
    Location:498535
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    cl26597
    Location:387448
    DUF2058; Uncharacterized protein conserved in bacteria (DUF2058)
  5. NM_028789.3NP_083065.1  putative E3 ubiquitin-protein ligase UNKL isoform 2

    See identical proteins and their annotated locations for NP_083065.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC130711
    Consensus CDS
    CCDS28510.1
    UniProtKB/Swiss-Prot
    Q5FWH2
    Related
    ENSMUSP00000015271.6, ENSMUST00000015271.12
    Conserved Domains (2) summary
    cl17238
    Location:196233
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    cl26597
    Location:85146
    DUF2058; Uncharacterized protein conserved in bacteria (DUF2058)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    25407336..25453417
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006525022.5XP_006525085.1  putative E3 ubiquitin-protein ligase UNKL isoform X1

    Conserved Domains (4) summary
    cd00162
    Location:601635
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    pfam00642
    Location:286310
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam18384
    Location:2560
    zf_CCCH_5; Unkempt Zinc finger domain 1 (Znf1)
    cl17238
    Location:599636
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
  2. XM_011246684.3XP_011244986.1  putative E3 ubiquitin-protein ligase UNKL isoform X2

    See identical proteins and their annotated locations for XP_011244986.1

    UniProtKB/TrEMBL
    E0CYD7
    Conserved Domains (3) summary
    pfam00642
    Location:100124
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    cl17238
    Location:498535
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    cl26597
    Location:387448
    DUF2058; Uncharacterized protein conserved in bacteria (DUF2058)
  3. XM_030250117.1XP_030105977.1  putative E3 ubiquitin-protein ligase UNKL isoform X7

    Conserved Domains (2) summary
    cl17238
    Location:188225
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    cl26597
    Location:77138
    DUF2058; Uncharacterized protein conserved in bacteria (DUF2058)
  4. XM_030250116.1XP_030105976.1  putative E3 ubiquitin-protein ligase UNKL isoform X7

    Conserved Domains (2) summary
    cl17238
    Location:188225
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    cl26597
    Location:77138
    DUF2058; Uncharacterized protein conserved in bacteria (DUF2058)
  5. XM_030250114.1XP_030105974.1  putative E3 ubiquitin-protein ligase UNKL isoform X4

    Conserved Domains (4) summary
    cd00162
    Location:424458
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    pfam00642
    Location:100124
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    cl17238
    Location:422459
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    cl26597
    Location:311372
    DUF2058; Uncharacterized protein conserved in bacteria (DUF2058)
  6. XM_030250112.1XP_030105972.1  putative E3 ubiquitin-protein ligase UNKL isoform X2

    UniProtKB/TrEMBL
    E0CYD7
    Conserved Domains (3) summary
    pfam00642
    Location:100124
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    cl17238
    Location:498535
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    cl26597
    Location:387448
    DUF2058; Uncharacterized protein conserved in bacteria (DUF2058)
  7. XM_030250113.2XP_030105973.1  putative E3 ubiquitin-protein ligase UNKL isoform X4

    Conserved Domains (4) summary
    cd00162
    Location:424458
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    pfam00642
    Location:100124
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    cl17238
    Location:422459
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    cl26597
    Location:311372
    DUF2058; Uncharacterized protein conserved in bacteria (DUF2058)
  8. XM_030250111.2XP_030105971.1  putative E3 ubiquitin-protein ligase UNKL isoform X2

    UniProtKB/TrEMBL
    E0CYD7
    Conserved Domains (3) summary
    pfam00642
    Location:100124
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    cl17238
    Location:498535
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    cl26597
    Location:387448
    DUF2058; Uncharacterized protein conserved in bacteria (DUF2058)
  9. XM_017317696.2XP_017173185.1  putative E3 ubiquitin-protein ligase UNKL isoform X3

    Conserved Domains (4) summary
    cd00162
    Location:552586
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    pfam00642
    Location:228252
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    cl17238
    Location:550587
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    cl26597
    Location:439500
    DUF2058; Uncharacterized protein conserved in bacteria (DUF2058)
  10. XM_030250115.2XP_030105975.1  putative E3 ubiquitin-protein ligase UNKL isoform X6

    Conserved Domains (2) summary
    cl17238
    Location:196233
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    cl26597
    Location:85146
    DUF2058; Uncharacterized protein conserved in bacteria (DUF2058)
  11. XM_036160816.1XP_036016709.1  putative E3 ubiquitin-protein ligase UNKL isoform X5

    Conserved Domains (2) summary
    cd16772
    Location:272309
    RING-HC_UNKL; RING finger, HC subclass, found in RING finger protein unkempt-like (UNKL) and similar proteins
    cl26597
    Location:161222
    DUF2058; Uncharacterized protein conserved in bacteria (DUF2058)
  12. XM_006525024.4XP_006525087.1  putative E3 ubiquitin-protein ligase UNKL isoform X5

    Conserved Domains (2) summary
    cd16772
    Location:272309
    RING-HC_UNKL; RING finger, HC subclass, found in RING finger protein unkempt-like (UNKL) and similar proteins
    cl26597
    Location:161222
    DUF2058; Uncharacterized protein conserved in bacteria (DUF2058)
  13. XM_017317697.1XP_017173186.1  putative E3 ubiquitin-protein ligase UNKL isoform X7

    UniProtKB/Swiss-Prot
    Q5FWH2
    Conserved Domains (2) summary
    cl17238
    Location:188225
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    cl26597
    Location:77138
    DUF2058; Uncharacterized protein conserved in bacteria (DUF2058)
  14. XM_017317698.2XP_017173187.1  putative E3 ubiquitin-protein ligase UNKL isoform X7

    UniProtKB/Swiss-Prot
    Q5FWH2
    Conserved Domains (2) summary
    cl17238
    Location:188225
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    cl26597
    Location:77138
    DUF2058; Uncharacterized protein conserved in bacteria (DUF2058)

RNA

  1. XR_003952197.1 RNA Sequence

  2. XR_004939592.1 RNA Sequence

  3. XR_003952198.2 RNA Sequence