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VCP valosin containing protein [ Homo sapiens (human) ]

Gene ID: 7415, updated on 5-Jul-2020

Summary

Official Symbol
VCPprovided by HGNC
Official Full Name
valosin containing proteinprovided by HGNC
Primary source
HGNC:HGNC:12666
See related
Ensembl:ENSG00000165280 MIM:601023
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p97; TERA; CDC48
Summary
This gene encodes a member of the AAA ATPase family of proteins. The encoded protein plays a role in protein degradation, intracellular membrane fusion, DNA repair and replication, regulation of the cell cycle, and activation of the NF-kappa B pathway. This protein forms a homohexameric complex that interacts with a variety of cofactors and extracts ubiquitinated proteins from lipid membranes or protein complexes. Mutations in this gene cause IBMPFD (inclusion body myopathy with paget disease of bone and frontotemporal dementia), ALS (amyotrophic lateral sclerosis) and Charcot-Marie-Tooth disease in human patients. [provided by RefSeq, Aug 2017]
Expression
Ubiquitous expression in appendix (RPKM 60.7), thyroid (RPKM 56.9) and 25 other tissues See more
Orthologs

Genomic context

See VCP in Genome Data Viewer
Location:
9p13.3
Exon count:
17
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (35056064..35072668, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (35056065..35072739, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene chromosome 9 open reading frame 131 Neighboring gene RNA, 7SL, cytoplasmic 338, pseudogene Neighboring gene FA complementation group G Neighboring gene phosphatidylinositol glycan anchor biosynthesis class O

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with VCP; predicted interaction to be within the endoplasmic reticulum to Golgi transport PubMed
Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 is identified to have a physical interaction with valosin containing protein (VCP) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Vpu vpu A functional ER-associated degradation pathway is required for Vpu-induced tetherin degradation. P97 ATPase (VCP) knockdown partially impairs Vpu-mediated tetherin degradation PubMed
vpu The VCP-UFD1L-NPL4 complex is required for HIV-1 Vpu-induced CD4 degradation in the ER-associated degradation pathway. The ATPase activity of VCP and ubiquitin binding to UFD1L are important for CD4 degradation by Vpu PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: FANCG

Homology

Clone Names

  • MGC8560, MGC131997, MGC148092

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ADP binding IEA
Inferred from Electronic Annotation
more info
 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
ATPase activity TAS
Traceable Author Statement
more info
PubMed 
BAT3 complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
K48-linked polyubiquitin modification-dependent protein binding IEA
Inferred from Electronic Annotation
more info
 
MHC class I protein binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
deubiquitinase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
lipid binding IEA
Inferred from Electronic Annotation
more info
 
polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
polyubiquitin modification-dependent protein binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin-like protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin-specific protease binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
ATP metabolic process IEA
Inferred from Electronic Annotation
more info
 
DNA repair NAS
Non-traceable Author Statement
more info
PubMed 
ER to Golgi vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
 
ER-associated misfolded protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ER-associated misfolded protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
ERAD pathway IDA
Inferred from Direct Assay
more info
PubMed 
ERAD pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
NADH metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
activation of cysteine-type endopeptidase activity involved in apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
aggresome assembly IEA
Inferred from Electronic Annotation
more info
 
autophagosome maturation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
autophagosome maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to arsenite ion IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to heat IMP
Inferred from Mutant Phenotype
more info
PubMed 
double-strand break repair IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum stress-induced pre-emptive quality control IMP
Inferred from Mutant Phenotype
more info
PubMed 
endoplasmic reticulum unfolded protein response TAS
Traceable Author Statement
more info
PubMed 
endosome to lysosome transport via multivesicular body sorting pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
error-free translesion synthesis TAS
Traceable Author Statement
more info
 
establishment of protein localization TAS
Traceable Author Statement
more info
PubMed 
flavin adenine dinucleotide catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
macroautophagy IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
macroautophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic spindle disassembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
positive regulation of ATP biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of Lys63-specific deubiquitinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of mitochondrial membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of oxidative phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein K63-linked deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of ubiquitin-specific protease activity IEA
Inferred from Electronic Annotation
more info
 
proteasomal protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
proteasome-mediated ubiquitin-dependent protein catabolic process NAS
Non-traceable Author Statement
more info
PubMed 
protein deubiquitination TAS
Traceable Author Statement
more info
 
protein folding TAS
Traceable Author Statement
more info
 
protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein ubiquitination NAS
Non-traceable Author Statement
more info
PubMed 
protein ubiquitination TAS
Traceable Author Statement
more info
 
regulation of aerobic respiration IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of apoptotic process TAS
Traceable Author Statement
more info
PubMed 
regulation of synapse organization IEA
Inferred from Electronic Annotation
more info
 
retrograde protein transport, ER to cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
retrograde protein transport, ER to cytosol IDA
Inferred from Direct Assay
more info
PubMed 
retrograde protein transport, ER to cytosol IMP
Inferred from Mutant Phenotype
more info
PubMed 
stress granule disassembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
translesion synthesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
transmembrane transport TAS
Traceable Author Statement
more info
 
ubiquitin-dependent ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-dependent ERAD pathway IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-dependent ERAD pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
ubiquitin-dependent ERAD pathway TAS
Traceable Author Statement
more info
PubMed 
viral genome replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
ATPase complex IEA
Inferred from Electronic Annotation
more info
 
Derlin-1 retrotranslocation complex IDA
Inferred from Direct Assay
more info
PubMed 
VCP-NPL4-UFD1 AAA ATPase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
VCP-NPL4-UFD1 AAA ATPase complex ISS
Inferred from Sequence or Structural Similarity
more info
 
VCP-NPL4-UFD1 AAA ATPase complex TAS
Traceable Author Statement
more info
PubMed 
VCP-NSFL1C complex ISS
Inferred from Sequence or Structural Similarity
more info
 
azurophil granule lumen TAS
Traceable Author Statement
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle ISS
Inferred from Sequence or Structural Similarity
more info
 
lipid droplet IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus HDA PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus TAS
Traceable Author Statement
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
proteasome complex IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
secretory granule lumen TAS
Traceable Author Statement
more info
 
site of double-strand break IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
transitional endoplasmic reticulum ATPase
Names
15S Mg(2+)-ATPase p97 subunit
TER ATPase
NP_001341856.1
NP_001341857.1
NP_009057.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007887.1 RefSeqGene

    Range
    5001..21675
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_657

mRNA and Protein(s)

  1. NM_001354927.1NP_001341856.1  transitional endoplasmic reticulum ATPase isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL353795, BU689324
    Conserved Domains (1) summary
    TIGR01243
    Location:1719
    CDC48; AAA family ATPase, CDC48 subfamily
  2. NM_001354928.1NP_001341857.1  transitional endoplasmic reticulum ATPase isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL353795, BU689324
    Conserved Domains (1) summary
    TIGR01243
    Location:1719
    CDC48; AAA family ATPase, CDC48 subfamily
  3. NM_007126.5NP_009057.1  transitional endoplasmic reticulum ATPase isoform 1

    See identical proteins and their annotated locations for NP_009057.1

    Status: REVIEWED

    Source sequence(s)
    BC007562, BC110913, BU689324, DA880782
    Consensus CDS
    CCDS6573.1
    UniProtKB/Swiss-Prot
    P55072
    UniProtKB/TrEMBL
    V9HW80
    Related
    ENSP00000351777.6, ENST00000358901.11
    Conserved Domains (1) summary
    TIGR01243
    Location:25764
    CDC48; AAA family ATPase, CDC48 subfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    35056064..35072668 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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