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Cluh clustered mitochondria (cluA/CLU1) homolog [ Mus musculus (house mouse) ]

Gene ID: 74148, updated on 26-Sep-2022

Summary

Official Symbol
Cluhprovided by MGI
Official Full Name
clustered mitochondria (cluA/CLU1) homologprovided by MGI
Primary source
MGI:MGI:1921398
See related
Ensembl:ENSMUSG00000020741 AllianceGenome:MGI:1921398
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kiaa0664; mKIAA0664; 1300001I01Rik
Summary
Predicted to enable mRNA binding activity. Predicted to be involved in intracellular distribution of mitochondria. Predicted to be active in cytoplasm. Is expressed in several structures, including adrenal gland; alimentary system; naris; pectoral girdle and thoracic body wall musculature; and renal calyx. Orthologous to human CLUH (clustered mitochondria homolog). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 48.6), adrenal adult (RPKM 47.6) and 28 other tissues See more
Orthologs
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Genomic context

See Cluh in Genome Data Viewer
Location:
11 B5; 11
Exon count:
27
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (74539707..74561680)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (74648881..74670854)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RAP1 GTPase activating protein 2 Neighboring gene predicted gene, 50590 Neighboring gene coiled-coil domain containing 92B Neighboring gene platelet-activating factor acetylhydrolase, isoform 1b, subunit 1 Neighboring gene predicted gene, 24211

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in intracellular distribution of mitochondria IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in intracellular distribution of mitochondria ISO
Inferred from Sequence Orthology
more info
 
involved_in mitochondrion organization ISO
Inferred from Sequence Orthology
more info
 
involved_in organelle organization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
clustered mitochondria protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081158.3NP_001074627.1  clustered mitochondria protein homolog isoform 1

    See identical proteins and their annotated locations for NP_001074627.1

    Status: VALIDATED

    Source sequence(s)
    AL607024, AL645971
    Consensus CDS
    CCDS36223.1
    UniProtKB/Swiss-Prot
    Q5SW19
    UniProtKB/TrEMBL
    A0A0R4J140
    Related
    ENSMUSP00000090593.6, ENSMUST00000092915.12
    Conserved Domains (6) summary
    sd00006
    Location:10621088
    TPR; TPR repeat [structural motif]
    pfam12807
    Location:809988
    eIF3_p135; Translation initiation factor eIF3 subunit 135
    pfam13236
    Location:394614
    CLU; Clustered mitochondria
    pfam13374
    Location:10611100
    TPR_10; Tetratricopeptide repeat
    pfam13424
    Location:11401217
    TPR_12; Tetratricopeptide repeat
    pfam15044
    Location:104177
    CLU_N; Mitochondrial function, CLU-N-term
  2. NM_001368711.1NP_001355640.1  clustered mitochondria protein homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL607024, AL645971
    UniProtKB/Swiss-Prot
    Q8CHD9
    Conserved Domains (5) summary
    sd00006
    Location:10241050
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:11041179
    TPR_12; Tetratricopeptide repeat
    pfam12807
    Location:769950
    eIF3_p135; Translation initiation factor eIF3 subunit 135
    pfam13236
    Location:356576
    CLU; Clustered mitochondria
    pfam15044
    Location:66139
    CLU_N; Mitochondrial function, CLU-N-term

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    74539707..74561680
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314805.3XP_017170294.1  clustered mitochondria protein homolog isoform X1

    Conserved Domains (5) summary
    sd00006
    Location:10611087
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:11411216
    TPR_12; Tetratricopeptide repeat
    pfam12807
    Location:806987
    eIF3_p135; Translation initiation factor eIF3 subunit 135
    pfam13236
    Location:394614
    CLU; Clustered mitochondria
    pfam15044
    Location:104177
    CLU_N; Mitochondrial function, CLU-N-term
  2. XM_006534353.4XP_006534416.1  clustered mitochondria protein homolog isoform X2

    See identical proteins and their annotated locations for XP_006534416.1

    UniProtKB/Swiss-Prot
    Q5SW19, Q8CHD9
    Conserved Domains (5) summary
    sd00006
    Location:10241050
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:11041179
    TPR_12; Tetratricopeptide repeat
    pfam12807
    Location:769950
    eIF3_p135; Translation initiation factor eIF3 subunit 135
    pfam13236
    Location:356576
    CLU; Clustered mitochondria
    pfam15044
    Location:66139
    CLU_N; Mitochondrial function, CLU-N-term