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F13a1 coagulation factor XIII, A1 subunit [ Mus musculus (house mouse) ]

Gene ID: 74145, updated on 18-Apr-2024

Summary

Official Symbol
F13a1provided by MGI
Official Full Name
coagulation factor XIII, A1 subunitprovided by MGI
Primary source
MGI:MGI:1921395
See related
Ensembl:ENSMUSG00000039109 AllianceGenome:MGI:1921395
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
F13a; 1200014I03Rik
Summary
This gene encodes subunit A of the coagulation factor XIII that catalyzes the final step of the blood coagulation pathway. The encoded protein associates with subunit B to form a heterotetrameric proenzyme that undergoes thrombin-mediated proteolysis to generate active factor XIIIa. The transglutaminase activity of factor XIIIa is required for the calcium-dependent crosslinking of fibrin, leading to the formation of a clot. Mice lacking the encoded protein display impaired reproduction and reduced survival due to bleeding episodes, hematothorax, hematoperitoneum and subcutaneous hemorrhage. Additionally, mice lacking the encoded protein exhibit impaired wound healing and inadequate healing of myocardial infarction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Expression
Broad expression in bladder adult (RPKM 12.1), mammary gland adult (RPKM 11.7) and 17 other tissues See more
Orthologs
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Genomic context

Location:
13 A3.3; 13 14.44 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (37051150..37234220, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (36867178..37050244, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38636 Neighboring gene predicted gene, 30177 Neighboring gene neuritin 1 Neighboring gene STARR-seq mESC enhancer starr_34196 Neighboring gene predicted gene, 30489 Neighboring gene STARR-seq mESC enhancer starr_34198 Neighboring gene STARR-seq mESC enhancer starr_34199 Neighboring gene STARR-seq mESC enhancer starr_34200 Neighboring gene predicted gene, 30240 Neighboring gene STARR-seq mESC enhancer starr_34201 Neighboring gene predicted gene, 30549 Neighboring gene Rho GTPase activating protein 20 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (6)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein-glutamine gamma-glutamyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein-glutamine gamma-glutamyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein-glutamine gamma-glutamyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within blood coagulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in blood coagulation, fibrin clot formation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in blood coagulation, fibrin clot formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in blood coagulation, fibrin clot formation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within hemostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in peptide cross-linking IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within peptide cross-linking IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptide cross-linking ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
coagulation factor XIII A chain
Names
coagulation factor XIII, alpha subunit
coagulation factor XIIIa
protein-glutamine gamma-glutamyltransferase A chain
transglutaminase A chain
NP_001159863.1
NP_083060.2
XP_036014090.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166391.1NP_001159863.1  coagulation factor XIII A chain

    See identical proteins and their annotated locations for NP_001159863.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK030914, AK049092, AV249730, BM239113
    Consensus CDS
    CCDS26456.1
    UniProtKB/Swiss-Prot
    Q3TNF9, Q8BH61, Q8BIP2
    UniProtKB/TrEMBL
    Q3V3W7
    Related
    ENSMUSP00000128316.2, ENSMUST00000164727.8
    Conserved Domains (4) summary
    smart00460
    Location:309400
    TGc; Transglutaminase/protease-like homologues
    COG1305
    Location:280408
    YebA; Transglutaminase-like enzyme, putative cysteine protease [Posttranslational modification, protein turnover, chaperones]
    pfam00868
    Location:47164
    Transglut_N; Transglutaminase family
    pfam00927
    Location:519623
    Transglut_C; Transglutaminase family, C-terminal ig like domain
  2. NM_028784.3NP_083060.2  coagulation factor XIII A chain

    See identical proteins and their annotated locations for NP_083060.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK049092, AV249730, BM239113
    Consensus CDS
    CCDS26456.1
    UniProtKB/Swiss-Prot
    Q3TNF9, Q8BH61, Q8BIP2
    UniProtKB/TrEMBL
    Q3V3W7
    Related
    ENSMUSP00000048667.9, ENSMUST00000037491.11
    Conserved Domains (4) summary
    smart00460
    Location:309400
    TGc; Transglutaminase/protease-like homologues
    COG1305
    Location:280408
    YebA; Transglutaminase-like enzyme, putative cysteine protease [Posttranslational modification, protein turnover, chaperones]
    pfam00868
    Location:47164
    Transglut_N; Transglutaminase family
    pfam00927
    Location:519623
    Transglut_C; Transglutaminase family, C-terminal ig like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    37051150..37234220 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158197.1XP_036014090.1  coagulation factor XIII A chain isoform X1

    Conserved Domains (2) summary
    smart00460
    Location:67158
    TGc; Transglutaminase/protease-like homologues
    pfam00927
    Location:277381
    Transglut_C; Transglutaminase family, C-terminal ig like domain