Pi16 peptidase inhibitor 16 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pi16provided by MGI
Official Full Name: peptidase inhibitor 16provided by MGI
Primary source: MGI:MGI:1921366
See related: Ensembl:ENSMUSG00000024011 AllianceGenome:MGI:1921366
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cripi; PI-16; 1200009H11Rik
Summary: Predicted to enable peptidase inhibitor activity. Acts upstream of or within negative regulation of cell growth involved in cardiac muscle cell development. Located in extracellular space. Is expressed in cranial ganglion; dorsal root ganglion; medulla oblongata basal plate mantle layer; and neural retina. Orthologous to human PI16 (peptidase inhibitor 16). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in bladder adult (RPKM 160.4), mammary gland adult (RPKM 72.5) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17; 17 A3.3

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (29537770..29547876)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (29318796..29328903)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overexpression of peptidase inhibitor 16 attenuates angiotensin II-induced cardiac fibrosis via regulating HDAC1 of cardiac fibroblasts.
Title: Overexpression of peptidase inhibitor 16 attenuates angiotensin II-induced cardiac fibrosis via regulating HDAC1 of cardiac fibroblasts.
these findings support a model in which PI16 promotes neuropathic pain by mediating a cross-talk between fibroblasts and the endothelial barrier leading to barrier opening, cellular influx, and increased pain
Title: The fibroblast-derived protein PI16 controls neuropathic pain.
our data indicate that PI16 suppresses chemerin activation in the myocardium and suggest that this circuit may be part of the cardiac stress response.
Title: Peptidase inhibitor 16 is a membrane-tethered regulator of chemerin processing in the myocardium.
PI16, a novel protein secreted from the heart, is strongly upregulated early in heart failure and inhibits growth of cardiomyocytes both in vitro and in vivo
Title: A secretion trap screen in yeast identifies protease inhibitor 16 as a novel antihypertrophic protein secreted from the heart.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (1) 1 citation
Endonuclease-mediated (4)

General gene information

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Homology

Homologs of the Pi16 gene: The Pi16 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, and rat.
Orthologs from Annotation Pipeline: 312 organisms have orthologs with human gene Pi16
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables peptidase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of cell growth involved in cardiac muscle cell development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of cell growth involved in cardiac muscle cell development	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within negative regulation of peptidase activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: peptidase inhibitor 16

Names: cysteine-rich protease inhibitor; protease inhibitor 16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023734.3 → NP_076223.3 peptidase inhibitor 16 precursor

Status: VALIDATED

Source sequence(s)

AB046537, AI587910, AK157854

Consensus CDS

CCDS28595.2

UniProtKB/Swiss-Prot

Q9ET66, Q9JJ56

UniProtKB/TrEMBL

E9QNE5

Related

ENSMUSP00000110349.3, ENSMUST00000114701.10

Conserved Domains (1) summary

cd05559
Location:35 → 168

SCP_HrTT-1; SCP_HrTT-1: SCP-like extracellular protein domain in HrTT-1, a tail-tip epidermis marker in ascidians. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

29537770..29547876

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006525014.2 → XP_006525077.1 peptidase inhibitor 16 isoform X1

Related

ENSMUSP00000116183.3, ENSMUST00000155348.3

Conserved Domains (1) summary

cd05559
Location:35 → 168

CAP_PI16_HrTT-1; CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of peptidase inhibitor 16 and HrTT-1 protein