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Crot carnitine O-octanoyltransferase [ Mus musculus (house mouse) ]

Gene ID: 74114, updated on 12-Mar-2023

Summary

Official Symbol
Crotprovided by MGI
Official Full Name
carnitine O-octanoyltransferaseprovided by MGI
Primary source
MGI:MGI:1921364
See related
Ensembl:ENSMUSG00000003623 AllianceGenome:MGI:1921364
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1200003H03Rik
Summary
Enables carnitine O-octanoyltransferase activity. Involved in carnitine metabolic process; coenzyme A metabolic process; and fatty acid metabolic process. Acts upstream of or within fatty acid transport. Located in peroxisome. Is expressed in several structures, including brain; ganglia; gut; liver; and spleen. Orthologous to human CROT (carnitine O-octanoyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver adult (RPKM 39.3), liver E18 (RPKM 15.1) and 23 other tissues See more
Orthologs
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Genomic context

See Crot in Genome Data Viewer
Location:
5; 5 A1
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (9016033..9047926, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (8966033..8997146, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene ATP-binding cassette, sub-family B (MDR/TAP), member 4 Neighboring gene calponin 3, acidic pseudogene Neighboring gene predicted gene, 31388 Neighboring gene coiled-coil domain-containing protein 72 pseudogene Neighboring gene predicted gene, 40264 Neighboring gene transmembrane protein 243, mitochondrial Neighboring gene cyclin D binding myb like transcription factor 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables carnitine O-octanoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables carnitine O-octanoyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables carnitine O-octanoyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in peroxisome IDA
Inferred from Direct Assay
more info
PubMed 
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
peroxisomal carnitine O-octanoyltransferase
Names
COT
NP_076222.1
XP_006503673.1
XP_036021444.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417830.1NP_001404759.1  peroxisomal carnitine O-octanoyltransferase isoform a

    Status: VALIDATED

    Source sequence(s)
    AC107763
  2. NM_001417831.1NP_001404760.1  peroxisomal carnitine O-octanoyltransferase isoform a

    Status: VALIDATED

    Source sequence(s)
    AC107763
  3. NM_001417832.1NP_001404761.1  peroxisomal carnitine O-octanoyltransferase isoform a

    Status: VALIDATED

    Source sequence(s)
    AC107763
  4. NM_001417833.1NP_001404762.1  peroxisomal carnitine O-octanoyltransferase isoform b

    Status: VALIDATED

    Source sequence(s)
    AC107763
  5. NM_023733.3NP_076222.1  peroxisomal carnitine O-octanoyltransferase isoform a

    See identical proteins and their annotated locations for NP_076222.1

    Status: VALIDATED

    Source sequence(s)
    AK004567
    Consensus CDS
    CCDS19087.1
    UniProtKB/Swiss-Prot
    Q921I4, Q9DC50
    Related
    ENSMUSP00000003720.5, ENSMUST00000003720.5
    Conserved Domains (1) summary
    pfam00755
    Location:20603
    Carn_acyltransf; Choline/Carnitine o-acyltransferase

RNA

  1. NR_184637.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC107763

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    9016033..9047926 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503610.4XP_006503673.1  peroxisomal carnitine O-octanoyltransferase isoform X2

    Conserved Domains (1) summary
    pfam00755
    Location:152531
    Carn_acyltransf; Choline/Carnitine o-acyltransferase
  2. XM_036165551.1XP_036021444.1  peroxisomal carnitine O-octanoyltransferase isoform X1

    UniProtKB/Swiss-Prot
    Q921I4
    Conserved Domains (1) summary
    pfam00755
    Location:20603
    Carn_acyltransf; Choline/Carnitine o-acyltransferase