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Cep55 centrosomal protein 55 [ Mus musculus (house mouse) ]

Gene ID: 74107, updated on 12-May-2024

Summary

Official Symbol
Cep55provided by MGI
Official Full Name
centrosomal protein 55provided by MGI
Primary source
MGI:MGI:1921357
See related
Ensembl:ENSMUSG00000024989 AllianceGenome:MGI:1921357
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1200008O12Rik; 2700032M20Rik
Summary
Predicted to enable identical protein binding activity. Predicted to be involved in cranial skeletal system development; establishment of protein localization; and midbody abscission. Predicted to act upstream of or within cell division. Located in intercellular bridge and midbody. Is expressed in germ cell of testis and ovary. Human ortholog(s) of this gene implicated in multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia and hydranencephaly. Orthologous to human CEP55 (centrosomal protein 55). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E11.5 (RPKM 14.2), placenta adult (RPKM 6.0) and 11 other tissues See more
Orthologs
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Genomic context

See Cep55 in Genome Data Viewer
Location:
19 C2; 19 32.69 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (38043423..38062873)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (38054970..38074425)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene myoferlin Neighboring gene predicted gene, 52397 Neighboring gene STARR-positive B cell enhancer mm9_chr19:38100719-38101020 Neighboring gene predicted gene, 52396 Neighboring gene STARR-seq mESC enhancer starr_46072 Neighboring gene STARR-positive B cell enhancer ABC_E971 Neighboring gene STARR-seq mESC enhancer starr_46073 Neighboring gene STARR-seq mESC enhancer starr_46074 Neighboring gene predicted gene, 23300 Neighboring gene free fatty acid receptor 4 Neighboring gene retinol binding protein 4, plasma

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in cranial skeletal system development ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of protein localization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in establishment of protein localization ISO
Inferred from Sequence Orthology
more info
 
involved_in midbody abscission ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within mitotic cytokinesis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Flemming body ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in intercellular bridge IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in midbody IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in midbody IDA
Inferred from Direct Assay
more info
PubMed 
located_in midbody ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
centrosomal protein of 55 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164362.2NP_001157834.1  centrosomal protein of 55 kDa isoform 1

    See identical proteins and their annotated locations for NP_001157834.1

    Status: VALIDATED

    Source sequence(s)
    AC101774, AK004655, AW538141
    Consensus CDS
    CCDS50429.1
    UniProtKB/Swiss-Prot
    Q8BT07, Q8C2J0, Q8K2I8, Q8R2Y4, Q9DBZ8
    Related
    ENSMUSP00000127961.2, ENSMUST00000169673.3
    Conserved Domains (2) summary
    COG1196
    Location:58397
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12180
    Location:171204
    EABR; TSG101 and ALIX binding domain of CEP55
  2. NM_001360663.1NP_001347592.1  centrosomal protein of 55 kDa isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC101774
    Consensus CDS
    CCDS50429.1
    UniProtKB/Swiss-Prot
    Q8BT07, Q8C2J0, Q8K2I8, Q8R2Y4, Q9DBZ8
    Related
    ENSMUSP00000157898.2, ENSMUST00000236044.2
    Conserved Domains (2) summary
    COG1196
    Location:58397
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12180
    Location:171204
    EABR; TSG101 and ALIX binding domain of CEP55
  3. NM_028293.2NP_082569.1  centrosomal protein of 55 kDa isoform 1

    See identical proteins and their annotated locations for NP_082569.1

    Status: VALIDATED

    Source sequence(s)
    AC101774, AK004655, AK028216, AW538141, CJ074252
    Consensus CDS
    CCDS50429.1
    UniProtKB/Swiss-Prot
    Q8BT07, Q8C2J0, Q8K2I8, Q8R2Y4, Q9DBZ8
    Related
    ENSMUSP00000093802.5, ENSMUST00000096096.12
    Conserved Domains (2) summary
    COG1196
    Location:58397
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12180
    Location:171204
    EABR; TSG101 and ALIX binding domain of CEP55
  4. NM_028760.3NP_083036.2  centrosomal protein of 55 kDa isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC101774, AK004655, AW538141
    Consensus CDS
    CCDS29782.1
    UniProtKB/Swiss-Prot
    Q8BT07
    Related
    ENSMUSP00000157871.2, ENSMUST00000237408.2
    Conserved Domains (2) summary
    pfam12180
    Location:171204
    EABR; TSG101 and ALIX binding domain of CEP55
    cl19219
    Location:256332
    DUF342; Protein of unknown function (DUF342)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    38043423..38062873
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527396.3XP_006527459.1  centrosomal protein of 55 kDa isoform X1

    See identical proteins and their annotated locations for XP_006527459.1

    UniProtKB/Swiss-Prot
    Q8BT07, Q8C2J0, Q8K2I8, Q8R2Y4, Q9DBZ8
    Conserved Domains (2) summary
    COG1196
    Location:58397
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12180
    Location:171204
    EABR; TSG101 and ALIX binding domain of CEP55
  2. XM_006527399.4XP_006527462.1  centrosomal protein of 55 kDa isoform X1

    See identical proteins and their annotated locations for XP_006527462.1

    UniProtKB/Swiss-Prot
    Q8BT07, Q8C2J0, Q8K2I8, Q8R2Y4, Q9DBZ8
    Conserved Domains (2) summary
    COG1196
    Location:58397
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12180
    Location:171204
    EABR; TSG101 and ALIX binding domain of CEP55
  3. XM_006527401.2XP_006527464.1  centrosomal protein of 55 kDa isoform X1

    See identical proteins and their annotated locations for XP_006527464.1

    UniProtKB/Swiss-Prot
    Q8BT07, Q8C2J0, Q8K2I8, Q8R2Y4, Q9DBZ8
    Conserved Domains (2) summary
    COG1196
    Location:58397
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12180
    Location:171204
    EABR; TSG101 and ALIX binding domain of CEP55
  4. XM_030251115.2XP_030106975.1  centrosomal protein of 55 kDa isoform X2

    Conserved Domains (2) summary
    COG1196
    Location:78244
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12180
    Location:1750
    EABR; TSG101 and ALIX binding domain of CEP55
  5. XM_006527402.3XP_006527465.1  centrosomal protein of 55 kDa isoform X2

    Conserved Domains (2) summary
    COG1196
    Location:78244
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12180
    Location:1750
    EABR; TSG101 and ALIX binding domain of CEP55
  6. XM_030251114.2XP_030106974.1  centrosomal protein of 55 kDa isoform X2

    Conserved Domains (2) summary
    COG1196
    Location:78244
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12180
    Location:1750
    EABR; TSG101 and ALIX binding domain of CEP55
  7. XM_006527397.5XP_006527460.1  centrosomal protein of 55 kDa isoform X1

    See identical proteins and their annotated locations for XP_006527460.1

    UniProtKB/Swiss-Prot
    Q8BT07, Q8C2J0, Q8K2I8, Q8R2Y4, Q9DBZ8
    Conserved Domains (2) summary
    COG1196
    Location:58397
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12180
    Location:171204
    EABR; TSG101 and ALIX binding domain of CEP55
  8. XM_011247381.4XP_011245683.1  centrosomal protein of 55 kDa isoform X1

    See identical proteins and their annotated locations for XP_011245683.1

    UniProtKB/Swiss-Prot
    Q8BT07, Q8C2J0, Q8K2I8, Q8R2Y4, Q9DBZ8
    Conserved Domains (2) summary
    COG1196
    Location:58397
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12180
    Location:171204
    EABR; TSG101 and ALIX binding domain of CEP55
  9. XM_006527398.5XP_006527461.1  centrosomal protein of 55 kDa isoform X1

    See identical proteins and their annotated locations for XP_006527461.1

    UniProtKB/Swiss-Prot
    Q8BT07, Q8C2J0, Q8K2I8, Q8R2Y4, Q9DBZ8
    Conserved Domains (2) summary
    COG1196
    Location:58397
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12180
    Location:171204
    EABR; TSG101 and ALIX binding domain of CEP55
  10. XM_036161710.1XP_036017603.1  centrosomal protein of 55 kDa isoform X1

    UniProtKB/Swiss-Prot
    Q8BT07, Q8C2J0, Q8K2I8, Q8R2Y4, Q9DBZ8
    Conserved Domains (2) summary
    COG1196
    Location:58397
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12180
    Location:171204
    EABR; TSG101 and ALIX binding domain of CEP55
  11. XM_036161711.1XP_036017604.1  centrosomal protein of 55 kDa isoform X2

    Conserved Domains (2) summary
    COG1196
    Location:78244
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12180
    Location:1750
    EABR; TSG101 and ALIX binding domain of CEP55
  12. XM_030251113.2XP_030106973.1  centrosomal protein of 55 kDa isoform X2

    Conserved Domains (2) summary
    COG1196
    Location:78244
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12180
    Location:1750
    EABR; TSG101 and ALIX binding domain of CEP55
  13. XM_036161712.1XP_036017605.1  centrosomal protein of 55 kDa isoform X2

    Conserved Domains (2) summary
    COG1196
    Location:78244
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12180
    Location:1750
    EABR; TSG101 and ALIX binding domain of CEP55