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Tjap1 tight junction associated protein 1 [ Mus musculus (house mouse) ]

Gene ID: 74094, updated on 6-Dec-2022

Summary

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Official Symbol
Tjap1provided by MGI
Official Full Name
tight junction associated protein 1provided by MGI
Primary source
MGI:MGI:1921344
See related
Ensembl:ENSMUSG00000012296 AllianceGenome:MGI:1921344
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pilt; Tjp4; 0610041D19Rik
Summary
Acts upstream of or within Golgi organization. Located in endosome; plasma membrane; and trans-Golgi network. Is expressed in tongue muscle and vertebral axis musculature. Orthologous to human TJAP1 (tight junction associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 23.4), limb E14.5 (RPKM 23.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Tjap1 in Genome Data Viewer
Location:
17; 17 C
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (46568777..46593991, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (46257851..46283063, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene Yip1 domain family, member 3 Neighboring gene leucine rich repeat containing 73 Neighboring gene predicted gene, 41588 Neighboring gene delta like non-canonical Notch ligand 2 Neighboring gene ATP-binding cassette, sub-family C (CFTR/MRP), member 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Pilt, a novel peripheral membrane protein at tight junctions in epithelial cells. Kawabe H, et al. J Biol Chem, 2001 Dec 21. PMID 11602598
  2. Pilt is a coiled-coil domain-containing protein that localizes at the trans-Golgi complex and regulates its structure. Tamaki H, et al. FEBS Lett, 2012 Sep 21. PMID 22841714
  3. Dlg3 trafficking and apical tight junction formation is regulated by nedd4 and nedd4-2 e3 ubiquitin ligases. Van Campenhout CA, et al. Dev Cell, 2011 Sep 13. PMID 21920314, Free PMC Article
  4. Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders. Li J, et al. Nat Neurosci, 2017 Aug. PMID 28671696, Free PMC Article
  5. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article

See all (25) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
acts_upstream_of_or_within Golgi organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in bicellular tight junction ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in cell junction IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
tight junction-associated protein 1
Names
hdlg-binding protein Pilt
protein incorporated later into tight junctions
tight junction protein 4 (peripheral)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252473.1 → NP_001239402.1  tight junction-associated protein 1

    See identical proteins and their annotated locations for NP_001239402.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AC116739
    Consensus CDS
    CCDS28824.1
    UniProtKB/Swiss-Prot
    Q9DCD5
    Related
    ENSMUSP00000153327.2, ENSMUST00000225080.2
    Conserved Domains (2) summary
    COG1196
    Location:17 → 159
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15453
    Location:260 → 538
    Pilt; Protein incorporated later into Tight Junctions

  2. NM_001252474.1 → NP_001239403.1  tight junction-associated protein 1

    See identical proteins and their annotated locations for NP_001239403.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AC116739, AK164925
    Consensus CDS
    CCDS28824.1
    UniProtKB/Swiss-Prot
    Q9DCD5
    Related
    ENSMUSP00000012440.7, ENSMUST00000012440.14
    Conserved Domains (2) summary
    COG1196
    Location:17 → 159
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15453
    Location:260 → 538
    Pilt; Protein incorporated later into Tight Junctions

  3. NM_001252475.1 → NP_001239404.1  tight junction-associated protein 1

    See identical proteins and their annotated locations for NP_001239404.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AC116739
    Consensus CDS
    CCDS28824.1
    UniProtKB/Swiss-Prot
    Q9DCD5
    Related
    ENSMUSP00000137220.2, ENSMUST00000180283.2
    Conserved Domains (2) summary
    COG1196
    Location:17 → 159
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15453
    Location:260 → 538
    Pilt; Protein incorporated later into Tight Junctions

  4. NM_028751.3 → NP_083027.1  tight junction-associated protein 1

    See identical proteins and their annotated locations for NP_083027.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AC116739, AK002882
    Consensus CDS
    CCDS28824.1
    UniProtKB/Swiss-Prot
    Q9DCD5
    Related
    ENSMUSP00000130710.3, ENSMUST00000164342.10
    Conserved Domains (2) summary
    COG1196
    Location:17 → 159
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15453
    Location:260 → 538
    Pilt; Protein incorporated later into Tight Junctions

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    46568777..46593991 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011246662.4 → XP_011244964.1  tight junction-associated protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011244964.1

    UniProtKB/Swiss-Prot
    Q8R5I2
    UniProtKB/TrEMBL
    I7H459
    Conserved Domains (2) summary
    COG1196
    Location:17 → 169
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15453
    Location:283 → 548
    Pilt; Protein incorporated later into Tight Junctions

  2. XM_011246667.4 → XP_011244969.1  tight junction-associated protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011244969.1

    UniProtKB/Swiss-Prot
    Q8R5I2
    UniProtKB/TrEMBL
    I7H459
    Conserved Domains (2) summary
    COG1196
    Location:17 → 169
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15453
    Location:283 → 548
    Pilt; Protein incorporated later into Tight Junctions

  3. XM_011246672.4 → XP_011244974.1  tight junction-associated protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011244974.1

    UniProtKB/Swiss-Prot
    Q8R5I2
    UniProtKB/TrEMBL
    I7H459
    Conserved Domains (2) summary
    COG1196
    Location:17 → 169
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15453
    Location:283 → 548
    Pilt; Protein incorporated later into Tight Junctions

  4. XM_011246668.4 → XP_011244970.1  tight junction-associated protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011244970.1

    UniProtKB/Swiss-Prot
    Q8R5I2
    UniProtKB/TrEMBL
    I7H459
    Conserved Domains (2) summary
    COG1196
    Location:17 → 169
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15453
    Location:283 → 548
    Pilt; Protein incorporated later into Tight Junctions

  5. XM_011246670.4 → XP_011244972.1  tight junction-associated protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011244972.1

    UniProtKB/Swiss-Prot
    Q8R5I2
    UniProtKB/TrEMBL
    I7H459
    Conserved Domains (2) summary
    COG1196
    Location:17 → 169
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15453
    Location:283 → 548
    Pilt; Protein incorporated later into Tight Junctions

  6. XM_011246677.4 → XP_011244979.1  tight junction-associated protein 1 isoform X2

    See identical proteins and their annotated locations for XP_011244979.1

    UniProtKB/Swiss-Prot
    Q9DCD5
    Conserved Domains (2) summary
    COG1196
    Location:17 → 159
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15453
    Location:260 → 538
    Pilt; Protein incorporated later into Tight Junctions

  7. XM_011246666.4 → XP_011244968.1  tight junction-associated protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011244968.1

    UniProtKB/Swiss-Prot
    Q8R5I2
    UniProtKB/TrEMBL
    I7H459
    Conserved Domains (2) summary
    COG1196
    Location:17 → 169
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15453
    Location:283 → 548
    Pilt; Protein incorporated later into Tight Junctions

  8. XM_011246663.4 → XP_011244965.1  tight junction-associated protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011244965.1

    UniProtKB/Swiss-Prot
    Q8R5I2
    UniProtKB/TrEMBL
    I7H459
    Conserved Domains (2) summary
    COG1196
    Location:17 → 169
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15453
    Location:283 → 548
    Pilt; Protein incorporated later into Tight Junctions

  9. XM_011246665.4 → XP_011244967.1  tight junction-associated protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011244967.1

    UniProtKB/Swiss-Prot
    Q8R5I2
    UniProtKB/TrEMBL
    I7H459
    Conserved Domains (2) summary
    COG1196
    Location:17 → 169
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15453
    Location:283 → 548
    Pilt; Protein incorporated later into Tight Junctions

  10. XM_011246669.4 → XP_011244971.1  tight junction-associated protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011244971.1

    UniProtKB/Swiss-Prot
    Q8R5I2
    UniProtKB/TrEMBL
    I7H459
    Conserved Domains (2) summary
    COG1196
    Location:17 → 169
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15453
    Location:283 → 548
    Pilt; Protein incorporated later into Tight Junctions

  11. XM_011246664.4 → XP_011244966.1  tight junction-associated protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011244966.1

    UniProtKB/Swiss-Prot
    Q8R5I2
    UniProtKB/TrEMBL
    I7H459
    Conserved Domains (2) summary
    COG1196
    Location:17 → 169
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15453
    Location:283 → 548
    Pilt; Protein incorporated later into Tight Junctions

  12. XM_011246674.4 → XP_011244976.1  tight junction-associated protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011244976.1

    UniProtKB/Swiss-Prot
    Q8R5I2
    UniProtKB/TrEMBL
    I7H459
    Conserved Domains (2) summary
    COG1196
    Location:17 → 169
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15453
    Location:283 → 548
    Pilt; Protein incorporated later into Tight Junctions

  13. XM_011246678.3 → XP_011244980.1  tight junction-associated protein 1 isoform X3

    See identical proteins and their annotated locations for XP_011244980.1

    Conserved Domains (1) summary
    pfam15453
    Location:149 → 414
    Pilt; Protein incorporated later into Tight Junctions

  14. XM_011246671.4 → XP_011244973.1  tight junction-associated protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011244973.1

    UniProtKB/Swiss-Prot
    Q8R5I2
    UniProtKB/TrEMBL
    I7H459
    Conserved Domains (2) summary
    COG1196
    Location:17 → 169
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15453
    Location:283 → 548
    Pilt; Protein incorporated later into Tight Junctions

  15. XM_011246673.4 → XP_011244975.1  tight junction-associated protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011244975.1

    UniProtKB/Swiss-Prot
    Q8R5I2
    UniProtKB/TrEMBL
    I7H459
    Conserved Domains (2) summary
    COG1196
    Location:17 → 169
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15453
    Location:283 → 548
    Pilt; Protein incorporated later into Tight Junctions

  16. XM_011246675.4 → XP_011244977.1  tight junction-associated protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011244977.1

    UniProtKB/Swiss-Prot
    Q8R5I2
    UniProtKB/TrEMBL
    I7H459
    Related
    ENSMUSP00000153632.2, ENSMUST00000225413.2
    Conserved Domains (2) summary
    COG1196
    Location:17 → 169
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15453
    Location:283 → 548
    Pilt; Protein incorporated later into Tight Junctions

  17. XM_011246676.3 → XP_011244978.1  tight junction-associated protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011244978.1

    UniProtKB/Swiss-Prot
    Q8R5I2
    UniProtKB/TrEMBL
    I7H459
    Conserved Domains (2) summary
    COG1196
    Location:17 → 169
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15453
    Location:283 → 548
    Pilt; Protein incorporated later into Tight Junctions
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DCD5.2 GenPept UniProtKB/Swiss-Prot:Q9DCD5

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