Them7 thioesterase superfamily member 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Them7provided by MGI
Official Full Name: thioesterase superfamily member 7provided by MGI
Primary source: MGI:MGI:1921338
See related: Ensembl:ENSMUSG00000055312 AllianceGenome:MGI:1921338
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 0610012H03Rik
Summary: Predicted to enable acyl-CoA hydrolase activity. Located in mitochondrion. Orthologous to human THEM7P (thioesterase superfamily member 7, pseudogene). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in kidney adult (RPKM 49.1) and liver adult (RPKM 8.3) See more
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Genomic context

Location:: 2; 2 E3

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (105054687..105210205)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (105224342..105379860)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Markers

D2Mit387 (e-PCR), detects polymorphism
- UniSTS:129286

RH127180 (e-PCR)
- UniSTS:207372

D2Mit44 (e-PCR), detects polymorphism
- UniSTS:116273

D2Mit442 (e-PCR), detects polymorphism
- UniSTS:129352

Homology

Homologs of the Them7 gene: The Them7 gene is conserved in dog, cow, rat, and M.oryzae.
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables acyl-CoA hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
located_in mitochondrion	HDA more info	PubMed

General protein information

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Preferred Names: uncharacterized protein LOC74088

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001159638.1 → NP_001153110.1 uncharacterized protein LOC74088 isoform 2

See identical proteins and their annotated locations for NP_001153110.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks the alternate exon containing the translation start site compared to variant 1. This transcript uses a downstream in-frame translation start site, and the encoded isoform (2) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AK002603, AK143809, CB952425

UniProtKB/TrEMBL

Q9DCP4

Conserved Domains (1) summary

cd00586
Location:38 → 175

4HBT; 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites. ...
NM_028747.2 → NP_083023.1 uncharacterized protein LOC74088 isoform 1

See identical proteins and their annotated locations for NP_083023.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK002603, AK143809, CB952425

Consensus CDS

CCDS38191.1

UniProtKB/TrEMBL

Q9DCP4

Related

ENSMUSP00000063340.3, ENSMUST00000068813.3

Conserved Domains (1) summary

cd00586
Location:62 → 199

4HBT; 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites. ...