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Asz1 ankyrin repeat, SAM and basic leucine zipper domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 74068, updated on 5-Mar-2024

Summary

Official Symbol
Asz1provided by MGI
Official Full Name
ankyrin repeat, SAM and basic leucine zipper domain containing 1provided by MGI
Primary source
MGI:MGI:1921318
See related
Ensembl:ENSMUSG00000010796 AllianceGenome:MGI:1921318
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gasz; ORF3; 4933400N19Rik
Summary
Involved in gamete generation and piRNA metabolic process. Located in pi-body. Is expressed in genitourinary system and limb mesenchyme. Orthologous to human ASZ1 (ankyrin repeat, SAM and basic leucine zipper domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 3.4), testis adult (RPKM 3.0) and 1 other tissue See more
Orthologs
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Genomic context

See Asz1 in Genome Data Viewer
Location:
6 A2; 6 8.09 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (18050963..18109060, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (18050964..18109061, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene suppression of tumorigenicity 7 Neighboring gene STARR-seq mESC enhancer starr_15259 Neighboring gene STARR-positive B cell enhancer mm9_chr6:17726341-17726642 Neighboring gene predicted gene, 52895 Neighboring gene STARR-seq mESC enhancer starr_15260 Neighboring gene STARR-seq mESC enhancer starr_15261 Neighboring gene STARR-seq mESC enhancer starr_15263 Neighboring gene wingless-type MMTV integration site family, member 2 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene NSA2 ribosome biogenesis homolog pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in germ cell development NAS
Non-traceable Author Statement
more info
PubMed 
involved_in male meiotic nuclear division IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulatory ncRNA-mediated gene silencing IEA
Inferred from Electronic Annotation
more info
 
involved_in retrotransposon silencing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in pi-body IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in pi-body IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1
Names
germ cell-specific ankyrin, SAM and basic leucine zipper domain containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023729.3NP_076218.3  ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1

    See identical proteins and their annotated locations for NP_076218.3

    Status: VALIDATED

    Source sequence(s)
    AF459789, BB020038, BC058859, BG088136
    Consensus CDS
    CCDS19929.1
    UniProtKB/Swiss-Prot
    G3X8S0, Q6PD92, Q8VD46, Q9JKQ7
    Related
    ENSMUSP00000010940.5, ENSMUST00000010940.11
    Conserved Domains (6) summary
    cd09521
    Location:273333
    SAM_ASZ1; SAM domain of ASZ1 subfamily
    cd00204
    Location:77202
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:83179
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:4799
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:168222
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:151179
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    18050963..18109060 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505176.3XP_006505239.1  ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006505239.1

    Conserved Domains (3) summary
    cd09521
    Location:124184
    SAM_ASZ1; SAM domain of ASZ1 subfamily
    sd00045
    Location:230
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:485
    Ank_2; Ankyrin repeats (3 copies)
  2. XM_006505178.3XP_006505241.1  ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006505241.1

    Conserved Domains (3) summary
    cd09521
    Location:124184
    SAM_ASZ1; SAM domain of ASZ1 subfamily
    sd00045
    Location:230
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:485
    Ank_2; Ankyrin repeats (3 copies)