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Rin2 Ras and Rab interactor 2 [ Mus musculus (house mouse) ]

Gene ID: 74030, updated on 24-Jan-2023

Summary

Official Symbol
Rin2provided by MGI
Official Full Name
Ras and Rab interactor 2provided by MGI
Primary source
MGI:MGI:1921280
See related
Ensembl:ENSMUSG00000001768 AllianceGenome:MGI:1921280
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RASSF4; 2010003K16Rik; 4632403N06Rik
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in positive regulation of endothelial cell migration; positive regulation of endothelial cell-matrix adhesion via fibronectin; and positive regulation of vasculogenesis. Predicted to act upstream of or within endocytosis. Predicted to be located in cytoplasm. Orthologous to human RIN2 (Ras and Rab interactor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 13.6), limb E14.5 (RPKM 10.8) and 26 other tissues See more
Orthologs
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Genomic context

See Rin2 in Genome Data Viewer
Location:
2; 2 G1
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (145613647..145729536)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (145771727..145887616)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene cDNA sequence BC039771 Neighboring gene predicted gene, 54120 Neighboring gene predicted gene, 34513 Neighboring gene predicted gene, 54121 Neighboring gene predicted gene, 39954 Neighboring gene TM2 domain containing 1 pseudogene Neighboring gene N(alpha)-acetyltransferase 20, NatB catalytic subunit

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within endocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell-matrix adhesion via fibronectin ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vasculogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in endocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ras and Rab interactor 2
Names
ras interaction/interference protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001406508.1NP_001393437.1  ras and Rab interactor 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL672100
    UniProtKB/Swiss-Prot
    Q99K06
  2. NM_001406509.1NP_001393438.1  ras and Rab interactor 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL672100
    UniProtKB/Swiss-Prot
    Q99K06
  3. NM_001406510.1NP_001393439.1  ras and Rab interactor 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL672100
  4. NM_028724.5NP_083000.5  ras and Rab interactor 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL672100
    Consensus CDS
    CCDS50734.1
    UniProtKB/Swiss-Prot
    Q9D684
    UniProtKB/TrEMBL
    F8WGD2
    Related
    ENSMUSP00000092053.5, ENSMUST00000094480.11
    Conserved Domains (3) summary
    smart00167
    Location:614730
    VPS9; Domain present in VPS9
    cd10394
    Location:41140
    SH2_RIN2; Src homology 2 (SH2) domain found in Ras and Rab interactor 2 (RIN2)-like proteins
    cd16131
    Location:751841
    RA_Rin2; Ras-associating (RA) domain found in Ras and Rab interactor 2 (Rin2)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    145613647..145729536
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500269.1XP_006500332.1  ras and Rab interactor 2 isoform X1

    See identical proteins and their annotated locations for XP_006500332.1

    UniProtKB/Swiss-Prot
    Q99K06, Q9D684
    Conserved Domains (3) summary
    smart00167
    Location:659775
    VPS9; Domain present in VPS9
    cd10394
    Location:86185
    SH2_RIN2; Src homology 2 (SH2) domain found in Ras and Rab interactor 2 (RIN2)-like proteins
    cd16131
    Location:796886
    RA_Rin2; Ras-associating (RA) domain found in Ras and Rab interactor 2 (Rin2)
  2. XM_006500270.4XP_006500333.1  ras and Rab interactor 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9D684
    Conserved Domains (3) summary
    smart00167
    Location:659775
    VPS9; Domain present in VPS9
    cd10394
    Location:86185
    SH2_RIN2; Src homology 2 (SH2) domain found in Ras and Rab interactor 2 (RIN2)-like proteins
    cd16131
    Location:796886
    RA_Rin2; Ras-associating (RA) domain found in Ras and Rab interactor 2 (Rin2)
  3. XM_036162626.1XP_036018519.1  ras and Rab interactor 2 isoform X2

    Conserved Domains (3) summary
    smart00167
    Location:606722
    VPS9; Domain present in VPS9
    cd10394
    Location:33132
    SH2_RIN2; Src homology 2 (SH2) domain found in Ras and Rab interactor 2 (RIN2)-like proteins
    cd16131
    Location:743833
    RA_Rin2; Ras-associating (RA) domain found in Ras and Rab interactor 2 (Rin2)
  4. XM_006500271.5XP_006500334.1  ras and Rab interactor 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9D684
    Related
    ENSMUSP00000105632.2, ENSMUST00000110005.8
    Conserved Domains (3) summary
    smart00167
    Location:659775
    VPS9; Domain present in VPS9
    cd10394
    Location:86185
    SH2_RIN2; Src homology 2 (SH2) domain found in Ras and Rab interactor 2 (RIN2)-like proteins
    cd16131
    Location:796886
    RA_Rin2; Ras-associating (RA) domain found in Ras and Rab interactor 2 (Rin2)
  5. XM_036162625.1XP_036018518.1  ras and Rab interactor 2 isoform X2

    Conserved Domains (3) summary
    smart00167
    Location:606722
    VPS9; Domain present in VPS9
    cd10394
    Location:33132
    SH2_RIN2; Src homology 2 (SH2) domain found in Ras and Rab interactor 2 (RIN2)-like proteins
    cd16131
    Location:743833
    RA_Rin2; Ras-associating (RA) domain found in Ras and Rab interactor 2 (Rin2)