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Ift57 intraflagellar transport 57 [ Mus musculus (house mouse) ]

Gene ID: 73916, updated on 8-Dec-2022

Summary

Official Symbol
Ift57provided by MGI
Official Full Name
intraflagellar transport 57provided by MGI
Primary source
MGI:MGI:1921166
See related
Ensembl:ENSMUSG00000032965 AllianceGenome:MGI:1921166
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hippi; MHS4R2; Esrrbl1; 4833420A15Rik
Summary
Predicted to enable DNA binding activity. Acts upstream of or within several processes, including cilium assembly; epithelial tube morphogenesis; and left/right pattern formation. Located in several cellular components, including cytoskeleton; dendrite terminus; and photoreceptor connecting cilium. Part of intraciliary transport particle B. Is expressed in several structures, including central nervous system; embryo ectoderm; embryo mesoderm; limb bud; and node. Human ortholog(s) of this gene implicated in orofaciodigital syndrome. Orthologous to human IFT57 (intraflagellar transport 57). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in frontal lobe adult (RPKM 12.9), testis adult (RPKM 10.1) and 21 other tissues See more
Orthologs
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Genomic context

See Ift57 in Genome Data Viewer
Location:
16; 16 B5
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (49519657..49585489)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (49699294..49765126)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35938 Neighboring gene predicted gene, 31494 Neighboring gene predicted gene, 52251 Neighboring gene predicted gene 15518 Neighboring gene predicted gene, 16619 Neighboring gene predicted gene 4633 Neighboring gene CD47 antigen (Rh-related antigen, integrin-associated signal transducer)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within apoptotic process ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in cilium assembly NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within heart looping IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intraciliary anterograde transport NAS
Non-traceable Author Statement
more info
PubMed 
involved_in intraciliary transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within intraciliary transport IC
Inferred by Curator
more info
PubMed 
acts_upstream_of keratinocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within left/right pattern formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within motile cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of keratinocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neural tube closure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in non-motile cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within non-motile cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in axoneme IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
PubMed 
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in ciliary base ISO
Inferred from Sequence Orthology
more info
 
is_active_in cilium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cilium IDA
Inferred from Direct Assay
more info
PubMed 
located_in cilium NAS
Non-traceable Author Statement
more info
PubMed 
located_in cilium TAS
Traceable Author Statement
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite terminus IDA
Inferred from Direct Assay
more info
PubMed 
part_of intraciliary transport particle B IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of intraciliary transport particle B IDA
Inferred from Direct Assay
more info
PubMed 
part_of intraciliary transport particle B ISO
Inferred from Sequence Orthology
more info
 
located_in photoreceptor connecting cilium IDA
Inferred from Direct Assay
more info
PubMed 
located_in photoreceptor connecting cilium ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
intraflagellar transport protein 57 homolog
Names
HIP1-interacting protein
Vestrogen-related receptor beta like 1
estrogen-related receptor beta like 1
huntingtin-interacting protein-1 protein interactor
intraflagellar transport 57 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028680.3NP_082956.2  intraflagellar transport protein 57 homolog

    See identical proteins and their annotated locations for NP_082956.2

    Status: PROVISIONAL

    Source sequence(s)
    AK047217
    Consensus CDS
    CCDS28211.1
    UniProtKB/Swiss-Prot
    Q8BXG3, Q9CUS6
    UniProtKB/TrEMBL
    A0A6P5R9B5, B2RQZ0
    Related
    ENSMUSP00000046645.5, ENSMUST00000046777.11
    Conserved Domains (1) summary
    pfam10498
    Location:45401
    IFT57; Intra-flagellar transport protein 57

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    49519657..49585489
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)