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Irak3 interleukin-1 receptor-associated kinase 3 [ Mus musculus (house mouse) ]

Gene ID: 73914, updated on 24-Jan-2023

Summary

Official Symbol
Irak3provided by MGI
Official Full Name
interleukin-1 receptor-associated kinase 3provided by MGI
Primary source
MGI:MGI:1921164
See related
Ensembl:ENSMUSG00000020227 AllianceGenome:MGI:1921164
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IRAK-M; 4833428C18Rik
Summary
Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in several processes, including negative regulation of macromolecule metabolic process; positive regulation of macrophage tolerance induction; and response to molecule of bacterial origin. Acts upstream of or within interleukin-1-mediated signaling pathway; positive regulation of NF-kappaB transcription factor activity; and protein autophosphorylation. Located in cytoplasm and nucleus. Used to study osteoporosis and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in asthma. Orthologous to human IRAK3 (interleukin 1 receptor associated kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 7.6), mammary gland adult (RPKM 3.2) and 17 other tissues See more
Orthologs
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Genomic context

See Irak3 in Genome Data Viewer
Location:
10; 10 D2
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (119977553..120038035, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (120141648..120202130, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene glutamate receptor interacting protein 1 Neighboring gene glutamate receptor interacting protein 1, opposite strand 1 Neighboring gene helicase (DNA) B Neighboring gene predicted gene, 34545 Neighboring gene predicted gene, 40781 Neighboring gene predicted gene, 38500 Neighboring gene predicted gene, 40782 Neighboring gene transmembrane BAX inhibitor motif containing 4 Neighboring gene LLP homolog, long-term synaptic facilitation (Aplysia)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Targeted (3)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in MyD88-dependent toll-like receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within apoptotic process RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
involved_in cytokine-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in interleukin-1-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within interleukin-1-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in interleukin-1-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of MAP kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of MAP kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cytokine-mediated signaling pathway IC
Inferred by Curator
more info
PubMed 
involved_in negative regulation of innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of interleukin-12 production IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of interleukin-12 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of interleukin-12 production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of macrophage cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein-containing complex disassembly ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of toll-like receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of tumor necrosis factor production IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NF-kappaB transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of macrophage tolerance induction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of apoptotic process RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
involved_in regulation of protein-containing complex disassembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to exogenous dsRNA IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to interleukin-1 ISO
Inferred from Sequence Orthology
more info
 
involved_in response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to peptidoglycan IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to virus IC
Inferred by Curator
more info
PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
interleukin-1 receptor-associated kinase 3
Names
IL-1 receptor-associated kinase M
inactive IL-1 receptor-associated kinase 3
NP_001346113.1
NP_082955.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359184.1NP_001346113.1  interleukin-1 receptor-associated kinase 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC144942, AK028436, AK029057
    Consensus CDS
    CCDS88092.1
    UniProtKB/TrEMBL
    D3Z007
    Related
    ENSMUSP00000118038.2, ENSMUST00000145665.8
    Conserved Domains (1) summary
    cd14160
    Location:92367
    PK_IRAK3; Pseudokinase domain of Interleukin-1 Receptor Associated Kinase 3
  2. NM_028679.4NP_082955.2  interleukin-1 receptor-associated kinase 3 isoform 1

    See identical proteins and their annotated locations for NP_082955.2

    Status: VALIDATED

    Source sequence(s)
    AC144942, AK029057
    Consensus CDS
    CCDS24204.1
    UniProtKB/Swiss-Prot
    Q8K1S8, Q8K4B2
    UniProtKB/TrEMBL
    Q0VB14
    Related
    ENSMUSP00000020448.5, ENSMUST00000020448.11
    Conserved Domains (3) summary
    cd08796
    Location:16102
    Death_IRAK-M; Death domain of Interleukin 1 Receptor Associated Kinase-M
    cd14160
    Location:184459
    PK_IRAK3; Pseudokinase domain of Interleukin-1 Receptor Associated Kinase 3
    pfam07714
    Location:184456
    Pkinase_Tyr; Protein tyrosine kinase

RNA

  1. NR_152856.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC144942, AK029057
    Related
    ENSMUST00000135106.2

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    119977553..120038035 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)