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Psmb11 proteasome (prosome, macropain) subunit, beta type, 11 [ Mus musculus (house mouse) ]

Gene ID: 73902, updated on 24-Jan-2023

Summary

Official Symbol
Psmb11provided by MGI
Official Full Name
proteasome (prosome, macropain) subunit, beta type, 11provided by MGI
Primary source
MGI:MGI:1921152
See related
Ensembl:ENSMUSG00000072423 AllianceGenome:MGI:1921152
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
beta5t; 5830406J20Rik
Summary
Predicted to enable endopeptidase activity. Acts upstream of or within CD8-positive, alpha-beta T cell differentiation and T cell differentiation in thymus. Part of proteasome core complex. Is expressed in thymus cortex epithelium. Orthologous to human PSMB11 (proteasome subunit beta 11). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See Psmb11 in Genome Data Viewer
Location:
14; 14 C2
Exon count:
1
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (54862767..54867013)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (54625310..54629556)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4931414P19 gene Neighboring gene proteasome (prosome, macropain) subunit, beta type 5 Neighboring gene microRNA 686 Neighboring gene cadherin-like 24 Neighboring gene microRNA 6948 Neighboring gene apoptotic chromatin condensation inducer 1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables threonine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of proteasome complex IEA
Inferred from Electronic Annotation
more info
 
part_of proteasome core complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of proteasome core complex, beta-subunit complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
proteasome subunit beta type-11
Names
proteasome beta 11 subunit
proteasome subunit beta-5t
proteasome subunit beta5t
NP_780413.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175204.4NP_780413.1  proteasome subunit beta type-11

    See identical proteins and their annotated locations for NP_780413.1

    Status: VALIDATED

    Source sequence(s)
    AK162727, CT009512
    Consensus CDS
    CCDS49491.1
    UniProtKB/Swiss-Prot
    Q149K8, Q8BG41
    Related
    ENSMUSP00000132140.2, ENSMUST00000097177.5
    Conserved Domains (2) summary
    TIGR03690
    Location:48253
    20S_bact_beta; proteasome, beta subunit, bacterial type
    cd03761
    Location:50237
    proteasome_beta_type_5; proteasome beta type-5 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    54862767..54867013
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)