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UQCRC2 ubiquinol-cytochrome c reductase core protein 2 [ Homo sapiens (human) ]

Gene ID: 7385, updated on 24-Nov-2020

Summary

Official Symbol
UQCRC2provided by HGNC
Official Full Name
ubiquinol-cytochrome c reductase core protein 2provided by HGNC
Primary source
HGNC:HGNC:12586
See related
Ensembl:ENSG00000140740 MIM:191329
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
QCR2; UQCR2; MC3DN5
Summary
The protein encoded by this gene is located in the mitochondrion, where it is part of the ubiquinol-cytochrome c reductase complex (also known as complex III). This complex constitutes a part of the mitochondrial respiratory chain. Defects in this gene are a cause of mitochondrial complex III deficiency nuclear type 5. [provided by RefSeq, Jul 2015]
Expression
Ubiquitous expression in heart (RPKM 179.2), duodenum (RPKM 111.5) and 25 other tissues See more
Orthologs

Genomic context

See UQCRC2 in Genome Data Viewer
Location:
16p12.2
Exon count:
14
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (21953361..21983660)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (21964609..21994668)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene SMG1 pseudogene 4 Neighboring gene ATP binding cassette subfamily A member 3 pseudogene Neighboring gene PDZ domain containing 9 Neighboring gene cell division cycle associated 8 pseudogene Neighboring gene islet cell autoantigen 1, 69kDa pseudogene Neighboring gene modulator of smoothened

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
aerobic respiration TAS
Traceable Author Statement
more info
PubMed 
mitochondrial electron transport, ubiquinol to cytochrome c TAS
Traceable Author Statement
more info
 
oxidative phosphorylation TAS
Traceable Author Statement
more info
PubMed 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
response to drug IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrial respiratory chain complex III IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial respiratory chain complex IV IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion HDA PubMed 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
cytochrome b-c1 complex subunit 2, mitochondrial
Names
complex III subunit 2
cytochrome bc-1 complex core protein II
ubiquinol-cytochrome c reductase core protein II
ubiquinol-cytochrome-c reductase complex core protein 2
NP_003357.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_042228.1 RefSeqGene

    Range
    5298..35597
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003366.4NP_003357.2  cytochrome b-c1 complex subunit 2, mitochondrial precursor

    See identical proteins and their annotated locations for NP_003357.2

    Status: REVIEWED

    Source sequence(s)
    AK094006, BQ181225
    Consensus CDS
    CCDS10601.1
    UniProtKB/Swiss-Prot
    P22695
    Related
    ENSP00000268379.4, ENST00000268379.9
    Conserved Domains (1) summary
    COG0612
    Location:37436
    PqqL; Predicted Zn-dependent peptidase [General function prediction only]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    21953361..21983660
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_017852933.1 Reference GRCh38.p13 PATCHES

    Range
    1121378..1151678 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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