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Atp6v1d ATPase, H+ transporting, lysosomal V1 subunit D [ Mus musculus (house mouse) ]

Gene ID: 73834, updated on 18-Apr-2024

Summary

Official Symbol
Atp6v1dprovided by MGI
Official Full Name
ATPase, H+ transporting, lysosomal V1 subunit Dprovided by MGI
Primary source
MGI:MGI:1921084
See related
Ensembl:ENSMUSG00000021114 AllianceGenome:MGI:1921084
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
VATD; Vma8; Atp6m; 1110004P10Rik
Summary
Predicted to enable proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in cilium assembly and protein localization to cilium. Predicted to act upstream of or within cell projection organization and ion transport. Predicted to be located in membrane. Predicted to be part of proton-transporting V-type ATPase complex. Predicted to colocalize with centrosome and cilium. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human ATP6V1D (ATPase H+ transporting V1 subunit D). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cortex adult (RPKM 56.2), frontal lobe adult (RPKM 53.1) and 22 other tissues See more
Orthologs
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Genomic context

Location:
12 C3; 12 35.51 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (78889756..78908810, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (78842982..78862008, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene golgi associated RAB2 interactor 2 Neighboring gene STARR-positive B cell enhancer ABC_E10759 Neighboring gene protein associated with LIN7 1, MAGUK family member Neighboring gene STARR-seq mESC enhancer starr_32577 Neighboring gene STARR-seq mESC enhancer starr_32578 Neighboring gene eukaryotic translation initiation factor 2, subunit 1 alpha Neighboring gene pleckstrin 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables proton-transporting ATPase activity, rotational mechanism IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of ATPase complex ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with centrosome ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with cilium ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in extrinsic component of synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of proton-transporting V-type ATPase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of proton-transporting V-type ATPase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of proton-transporting V-type ATPase complex ISO
Inferred from Sequence Orthology
more info
 
part_of proton-transporting V-type ATPase, V1 domain ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of transmembrane transporter complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
V-type proton ATPase subunit D
Names
ATPase, H+ transporting lysosomal (vacuolar proton pump)
ATPase, H+ transporting, V1 subunit D
ATPase, H+ transporting, lysosomal 34kD, V1 subunit D
V-ATPase 28 kDa accessory protein
V-ATPase subunit D
lysosomal 34kDa
vacuolar proton pump subunit D
NP_076210.1
XP_030102816.1
XP_036013525.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023721.2NP_076210.1  V-type proton ATPase subunit D

    See identical proteins and their annotated locations for NP_076210.1

    Status: VALIDATED

    Source sequence(s)
    AK147910, BY096594
    Consensus CDS
    CCDS26002.1
    UniProtKB/Swiss-Prot
    P57746
    UniProtKB/TrEMBL
    Q3U684, Q3U861, Q3UJH5
    Related
    ENSMUSP00000021536.8, ENSMUST00000021536.9
    Conserved Domains (1) summary
    pfam01813
    Location:17202
    ATP-synt_D; ATP synthase subunit D

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    78889756..78908810 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157632.1XP_036013525.1  V-type proton ATPase subunit D isoform X2

    UniProtKB/TrEMBL
    Q3U684, Q3UJH5
    Conserved Domains (1) summary
    pfam01813
    Location:1184
    ATP-synt_D; ATP synthase subunit D
  2. XM_030246956.2XP_030102816.1  V-type proton ATPase subunit D isoform X1

    UniProtKB/Swiss-Prot
    P57746
    UniProtKB/TrEMBL
    Q3U684, Q3U861, Q3UJH5
    Conserved Domains (1) summary
    pfam01813
    Location:17202
    ATP-synt_D; ATP synthase subunit D