Format

Send to:

Choose Destination

UPP1 uridine phosphorylase 1 [ Homo sapiens (human) ]

Gene ID: 7378, updated on 9-Dec-2018

Summary

Official Symbol
UPP1provided by HGNC
Official Full Name
uridine phosphorylase 1provided by HGNC
Primary source
HGNC:HGNC:12576
See related
Ensembl:ENSG00000183696 MIM:191730
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UP; UPP; UPASE; UDRPASE
Summary
This gene encodes a uridine phosphorylase, an enzyme that catalyzes the reversible phosphorylation of uridine (or 2'- deoxyuridine) to uracil and ribose-1-phosphate (or deoxyribose-1-phosphate). The encoded enzyme functions in the degradation and salvage of pyrimidine ribonucleosides. [provided by RefSeq, Oct 2016]
Expression
Broad expression in bone marrow (RPKM 27.1), esophagus (RPKM 7.4) and 19 other tissues See more
Orthologs

Genomic context

See UPP1 in Genome Data Viewer
Location:
7p12.3
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (48088308..48108746)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (48128355..48148330)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375270 Neighboring gene Sad1 and UNC84 domain containing 3 Neighboring gene chromosome 7 open reading frame 57 Neighboring gene uncharacterized LOC105375271 Neighboring gene ATP binding cassette subfamily A member 13

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat 47-59 peptide downregulates gene expression of uridine phosphorylase 1 (UPP1) in U-937 macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
uridine phosphorylase activity EXP
Inferred from Experiment
more info
PubMed 
Process Evidence Code Pubs
UMP salvage IEA
Inferred from Electronic Annotation
more info
 
cellular response to glucose starvation IEA
Inferred from Electronic Annotation
more info
 
nucleobase-containing compound metabolic process TAS
Traceable Author Statement
more info
PubMed 
nucleotide catabolic process IEA
Inferred from Electronic Annotation
more info
 
pyrimidine nucleoside catabolic process TAS
Traceable Author Statement
more info
 
pyrimidine nucleoside salvage TAS
Traceable Author Statement
more info
 
uridine catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
uridine phosphorylase 1
Names
UPase 1
urdPase 1
NP_001274355.1
NP_001274357.1
NP_001274358.1
NP_001274359.1
NP_003355.1
XP_005249895.1
XP_011513814.1
XP_011513815.1
XP_011513816.1
XP_011513817.1
XP_024302681.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051802.1 RefSeqGene

    Range
    5001..25131
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001287426.1NP_001274355.1  uridine phosphorylase 1 isoform a

    See identical proteins and their annotated locations for NP_001274355.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 8. Variants 1, 3 and 8 encode the same isoform (a).
    Source sequence(s)
    AK297863, BC007348, BF027447, BF668084
    Consensus CDS
    CCDS5507.1
    UniProtKB/Swiss-Prot
    Q16831
    UniProtKB/TrEMBL
    B4DND0
    Related
    ENSP00000330032.4, ENST00000331803.8
    Conserved Domains (1) summary
    TIGR01719
    Location:23309
    euk_UDPppase; uridine phosphorylase
  2. NM_001287428.1NP_001274357.1  uridine phosphorylase 1 isoform b

    See identical proteins and their annotated locations for NP_001274357.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks three exons in the 5' coding region and initiates translation at an alternate start codon, compared to variant 8. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a. Variants 4, 5 and 6 all encode isoform b.
    Source sequence(s)
    BC007348, BF027447, BF668084, BM557506
    UniProtKB/Swiss-Prot
    Q16831
    UniProtKB/TrEMBL
    Q86Y75
    Conserved Domains (1) summary
    cl00303
    Location:10172
    PNP_UDP_1; Phosphorylase superfamily
  3. NM_001287429.1NP_001274358.1  uridine phosphorylase 1 isoform b

    See identical proteins and their annotated locations for NP_001274358.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks three exons in the 5' coding region and initiates translation at an alternate start codon, compared to variant 8. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a. Variants 4, 5 and 6 all encode isoform b.
    Source sequence(s)
    BC007348, BE901028, BI199725, CD105246
    UniProtKB/Swiss-Prot
    Q16831
    UniProtKB/TrEMBL
    Q86Y75
    Conserved Domains (1) summary
    cl00303
    Location:10172
    PNP_UDP_1; Phosphorylase superfamily
  4. NM_001287430.1NP_001274359.1  uridine phosphorylase 1 isoform b

    See identical proteins and their annotated locations for NP_001274359.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, lacks three exons in the 5' coding region and initiates translation at an alternate start codon, compared to variant 8. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a. Variants 4, 5 and 6 all encode isoform b.
    Source sequence(s)
    AK297863, BC007348, BC047030
    UniProtKB/Swiss-Prot
    Q16831
    UniProtKB/TrEMBL
    B4DND0, Q86Y75
    Conserved Domains (1) summary
    cl00303
    Location:10172
    PNP_UDP_1; Phosphorylase superfamily
  5. NM_001362774.1NP_001349703.1  uridine phosphorylase 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) represents the longest transcript and encodes the longer isoform (a). Both variants 1, 3 and 8 encode isoform a.
    Source sequence(s)
    AC069279, BC007348, BU528636, X90858
    Consensus CDS
    CCDS5507.1
    Conserved Domains (1) summary
    TIGR01719
    Location:23309
    euk_UDPppase; uridine phosphorylase
  6. NM_003364.4NP_003355.1  uridine phosphorylase 1 isoform a

    See identical proteins and their annotated locations for NP_003355.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 8. Variants 1, 3 and 8 encode the same isoform (a).
    Source sequence(s)
    AC122132, AK297863, BC001405, BC007348, X90858
    Consensus CDS
    CCDS5507.1
    UniProtKB/Swiss-Prot
    Q16831
    UniProtKB/TrEMBL
    B4DND0
    Related
    ENSP00000378931.4, ENST00000395564.8
    Conserved Domains (1) summary
    TIGR01719
    Location:23309
    euk_UDPppase; uridine phosphorylase

RNA

  1. NR_109837.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' region, and lacks two exons and uses an alternate splice site in the central region, compared to variant 8. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 3, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD)
    Source sequence(s)
    AK297863, BC007348, BC053592

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p12 Primary Assembly

    Range
    48088308..48108746
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024446913.1XP_024302681.1  uridine phosphorylase 1 isoform X1

    Conserved Domains (1) summary
    TIGR01719
    Location:23309
    euk_UDPppase; uridine phosphorylase
  2. XM_011515512.2XP_011513814.1  uridine phosphorylase 1 isoform X1

    See identical proteins and their annotated locations for XP_011513814.1

    UniProtKB/Swiss-Prot
    Q16831
    Conserved Domains (1) summary
    TIGR01719
    Location:23309
    euk_UDPppase; uridine phosphorylase
  3. XM_011515513.2XP_011513815.1  uridine phosphorylase 1 isoform X3

    See identical proteins and their annotated locations for XP_011513815.1

    Conserved Domains (1) summary
    cl00303
    Location:25226
    PNP_UDP_1; Phosphorylase superfamily
  4. XM_011515514.2XP_011513816.1  uridine phosphorylase 1 isoform X3

    See identical proteins and their annotated locations for XP_011513816.1

    Conserved Domains (1) summary
    cl00303
    Location:25226
    PNP_UDP_1; Phosphorylase superfamily
  5. XM_005249838.4XP_005249895.1  uridine phosphorylase 1 isoform X2

    See identical proteins and their annotated locations for XP_005249895.1

    Conserved Domains (1) summary
    cl00303
    Location:1245
    PNP_UDP_1; Phosphorylase superfamily
  6. XM_011515515.2XP_011513817.1  uridine phosphorylase 1 isoform X4

    See identical proteins and their annotated locations for XP_011513817.1

    Conserved Domains (1) summary
    cl00303
    Location:1200
    PNP_UDP_1; Phosphorylase superfamily

RNA

  1. XR_001744869.1 RNA Sequence

  2. XR_001744870.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_181597.1: Suppressed sequence

    Description
    NM_181597.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Support Center