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UCK2 uridine-cytidine kinase 2 [ Homo sapiens (human) ]

Gene ID: 7371, updated on 6-Sep-2022

Summary

Official Symbol
UCK2provided by HGNC
Official Full Name
uridine-cytidine kinase 2provided by HGNC
Primary source
HGNC:HGNC:12562
See related
Ensembl:ENSG00000143179 MIM:609329; AllianceGenome:HGNC:12562
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UK; UMPK; TSA903
Summary
This gene encodes a pyrimidine ribonucleoside kinase. The encoded protein (EC 2.7.1.48) catalyzes phosphorylation of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP), respectively.[provided by RefSeq, Oct 2010]
Expression
Ubiquitous expression in colon (RPKM 6.8), small intestine (RPKM 6.1) and 25 other tissues See more
Orthologs
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Genomic context

See UCK2 in Genome Data Viewer
Location:
1q24.1
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (165827614..165911618)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (165173785..165257744)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (165796851..165880855)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene TMCO1 antisense RNA 1 Neighboring gene ribosomal protein L26 pseudogene 12 Neighboring gene Sharpr-MPRA regulatory region 1747 Neighboring gene Sharpr-MPRA regulatory region 10580 Neighboring gene Sharpr-MPRA regulatory region 2437 Neighboring gene microRNA 3658 Neighboring gene post-GPI attachment to proteins 2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A genome-wide association study of testicular germ cell tumor.
EBI GWAS Catalog
Identification of nine new susceptibility loci for testicular cancer, including variants near DAZL and PRDM14.
EBI GWAS Catalog
Meta-analysis identifies four new loci associated with testicular germ cell tumor.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
nucleocapsid gag HIV-1 NC upregulates uridine-cytidine kinase 2 in HEK 293T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp686M04245

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables cytidine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables uridine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in CMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in CTP salvage IDA
Inferred from Direct Assay
more info
PubMed 
involved_in CTP salvage IEA
Inferred from Electronic Annotation
more info
 
involved_in UMP salvage IDA
Inferred from Direct Assay
more info
PubMed 
involved_in UMP salvage IEA
Inferred from Electronic Annotation
more info
 
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
uridine-cytidine kinase 2
Names
cytidine monophosphokinase 2
testis-specific protein TSA903
uridine kinase
uridine monophosphate kinase
uridine monophosphokinase 2
NP_001350497.1
NP_036606.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363568.2NP_001350497.1  uridine-cytidine kinase 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL358115, AL451074
    Consensus CDS
    CCDS86027.1
    UniProtKB/TrEMBL
    A0A2R8Y653
    Related
    ENSP00000494961.1, ENST00000642653.1
    Conserved Domains (1) summary
    cd02023
    Location:13207
    UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...
  2. NM_012474.5NP_036606.2  uridine-cytidine kinase 2 isoform 1

    See identical proteins and their annotated locations for NP_036606.2

    Status: REVIEWED

    Source sequence(s)
    AL358115, BC002906, BM714864, DR762696
    Consensus CDS
    CCDS1252.1
    UniProtKB/Swiss-Prot
    Q9BU42, Q9BZX2
    UniProtKB/TrEMBL
    A0A024R912
    Related
    ENSP00000356853.4, ENST00000367879.9
    Conserved Domains (1) summary
    cd02023
    Location:22228
    UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    165827614..165911618
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    165173785..165257744
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)