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UCK2 uridine-cytidine kinase 2 [ Homo sapiens (human) ]

Gene ID: 7371, updated on 9-Dec-2018

Summary

Official Symbol
UCK2provided by HGNC
Official Full Name
uridine-cytidine kinase 2provided by HGNC
Primary source
HGNC:HGNC:12562
See related
Ensembl:ENSG00000143179 MIM:609329
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UK; UMPK; TSA903
Summary
This gene encodes a pyrimidine ribonucleoside kinase. The encoded protein (EC 2.7.1.48) catalyzes phosphorylation of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP), respectively.[provided by RefSeq, Oct 2010]
Expression
Ubiquitous expression in colon (RPKM 6.8), small intestine (RPKM 6.1) and 25 other tissues See more
Orthologs

Genomic context

See UCK2 in Genome Data Viewer
Location:
1q24.1
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (165827495..165911618)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (165796732..165880855)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene TMCO1 antisense RNA 1 Neighboring gene ribosomal protein L26 pseudogene 12 Neighboring gene microRNA 3658 Neighboring gene post-GPI attachment to proteins 2 pseudogene Neighboring gene ribosomal protein S3a pseudogene 10

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study of testicular germ cell tumor.
NHGRI GWA Catalog
Identification of nine new susceptibility loci for testicular cancer, including variants near DAZL and PRDM14.
NHGRI GWA Catalog
Meta-analysis identifies four new loci associated with testicular germ cell tumor.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
nucleocapsid gag HIV-1 NC upregulates uridine-cytidine kinase 2 in HEK 293T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp686M04245

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoside kinase activity EXP
Inferred from Experiment
more info
PubMed 
nucleoside kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
CMP salvage IEA
Inferred from Electronic Annotation
more info
 
CTP salvage IEA
Inferred from Electronic Annotation
more info
 
UMP salvage IEA
Inferred from Electronic Annotation
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
pyrimidine nucleoside salvage TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
uridine-cytidine kinase 2
Names
cytidine monophosphokinase 2
testis-specific protein TSA903
uridine kinase
uridine monophosphate kinase
uridine monophosphokinase 2
NP_036606.2
XP_011508272.2
XP_016857725.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363568.1NP_001350497.1  uridine-cytidine kinase 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL358115, AL451074
    Consensus CDS
    CCDS86027.1
    Conserved Domains (1) summary
    cd02023
    Location:13207
    UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...
  2. NM_012474.5NP_036606.2  uridine-cytidine kinase 2 isoform 1

    See identical proteins and their annotated locations for NP_036606.2

    Status: REVIEWED

    Source sequence(s)
    AL358115, BC002906, BM714864, DR762696
    Consensus CDS
    CCDS1252.1
    UniProtKB/Swiss-Prot
    Q9BZX2
    UniProtKB/TrEMBL
    A0A024R912
    Related
    ENSP00000356853.4, ENST00000367879.8
    Conserved Domains (1) summary
    cd02023
    Location:22228
    UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    165827495..165911618
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017002236.1XP_016857725.1  uridine-cytidine kinase 2 isoform X1

    Related
    ENSP00000494961.1, ENST00000642653.1
    Conserved Domains (1) summary
    cd02023
    Location:13207
    UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...
  2. XM_011509970.2XP_011508272.2  uridine-cytidine kinase 2 isoform X2

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