Dppa3 developmental pluripotency-associated 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dppa3provided by MGI
Official Full Name: developmental pluripotency-associated 3provided by MGI
Primary source: MGI:MGI:1920958
See related: Ensembl:ENSMUSG00000046323 AllianceGenome:MGI:1920958
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PCG7; PGC7; Stella; 2410075G02Rik
Summary: Enables methylated histone binding activity. Involved in negative regulation of DNA demethylation; protection of DNA demethylation of female pronucleus; and regulation of genetic imprinting. Acts upstream of or within embryonic cleavage. Located in cytoplasm; female pronucleus; and male pronucleus. Is expressed in several structures, including central nervous system; early conceptus; gonad; hindgut diverticulum; and primordial germ cell. Orthologous to human DPPA3 (developmental pluripotency associated 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 6; 6 F1

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (122603383..122607230)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (122626424..122630271)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structural basis for the unique multifaceted interaction of DPPA3 with the UHRF1 PHD finger.
Title: Structural basis for the unique multifaceted interaction of DPPA3 with the UHRF1 PHD finger.
These results emphasize that Lin28a plays an important role during the naive-primed state conversion of ES cells, which is partially mediated by a Lin28a-let-7-Dnmt3a/b-Dppa3 axis.
Title: Dppa3 is critical for Lin28a-regulated ES cells naïve-primed state conversion.
Stella safeguards the unique oocyte epigenome by preventing aberrant de novo DNA methylation mediated by DNMT1 and UHRF1
Title: Stella safeguards the oocyte methylome by preventing de novo methylation mediated by DNMT1.
Stella insufficiency in oocytes may represent a critical mechanism that mediates the phenotypic effects of maternal obesity in embryos and offspring.
Title: Embryonic defects induced by maternal obesity in mice derive from Stella insufficiency in oocytes.
To determine the reprogramming potential of germ cell- specific genes, a polycistronic gene cassette expressing Stella, Oct4 and Nanos2 in a lentiviral-based vector, was designed.
Title: Suppression of dsRNA response genes and innate immunity following Oct4, Stella, and Nanos2 overexpression in mouse embryonic fibroblasts.
Overexpression of Stella improves the efficiency of nuclear transfer reprogramming
Title: Overexpression of Stella improves the efficiency of nuclear transfer reprogramming.
The absence of the DPPA3 cleavage products adversely affects pre-implantation development and female fertility.
Title: Cytoplasmic cleavage of DPPA3 is required for intracellular trafficking and cleavage-stage development in mice.
Through an in-depth bioinformatic analysis of potential interactors, PGC7 was linked to critical cellular processes including translation, RNA processing, cell cycle, and regulation of heterochromatin structure.
Title: Comprehensive Proteomic Analysis of PGC7-Interacting Proteins.
PRDM1 and STELLA, while overlapping in putative primordial germ cells, also co-localize in several other tissues
Title: PRDM1/BLIMP1 is widely distributed to the nascent fetal-placental interface in the mouse gastrula.
The authors show that loss of maternal Stella results in widespread transcriptional mis-regulation and a partial failure of maternal-to-zygotic transition.
Title: Stella modulates transcriptional and endogenous retrovirus programs during maternal-to-zygotic transition.

Submit: New GeneRIF Correction See all GeneRIFs (26)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:489295

Dppa3 (e-PCR), detects polymorphism
- UniSTS:254292

Dppa3 (e-PCR), detects polymorphism
- UniSTS:526817

Homology

Orthologs from Annotation Pipeline: 115 organisms have orthologs with human gene Dppa3
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables methylated histone binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables methylated histone binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryonic cleavage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maintenance of DNA methylation at imprinted genes	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in maintenance of DNA methylation at imprinted genes	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA demethylation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in negative regulation of DNA demethylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of genetic imprinting	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in regulation of genetic imprinting	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in female pronucleus	IDA Inferred from Direct Assay more info	PubMed
NOT located_in male pronucleus	IDA Inferred from Direct Assay more info	PubMed
located_in male pronucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: developmental pluripotency-associated protein 3

Names: compaction-associated protein 1; primordial germ cell 7; primordial germ cell protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.