Psma8 proteasome subunit alpha 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Psma8provided by MGI
Official Full Name: proteasome subunit alpha 8provided by MGI
Primary source: MGI:MGI:1920927
See related: Ensembl:ENSMUSG00000036743 AllianceGenome:MGI:1920927
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2410072D24Rik
Summary: Involved in meiotic cell cycle; proteasomal protein catabolic process; and regulation of meiosis I. Located in nucleus. Part of spermatoproteasome complex. Orthologous to human PSMA8 (proteasome 20S subunit alpha 8). [provided by Alliance of Genome Resources, Mar 2025]
Expression: Biased expression in testis adult (RPKM 11.2) and liver E14 (RPKM 0.4) See more
Orthologs: human all
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Genomic context

Location:: 18 A1; 18 8.25 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (14839192..14895358)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (14706135..14762301)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study in mouse model shows that Psma8 is localized to and dependent on the central element of the synaptonemal complex and promotes the assembly of the proteasome activator PA200. Accordingly, synapsis-deficient mice show delocalization of Psma8. Loss of Psma8 leads to infertility in males.
Title: The PSMA8 subunit of the spermatoproteasome is essential for proper meiotic exit and mouse fertility.
meiosis I progression in spermatogenesis, particularly entry into and exit from M-phase, requires the proteasomal activity of proteasome subunit alpha 8 (PSMA8)-associated proteasomes.
Title: Meiosis I progression in spermatogenesis requires a type of testis-specific 20S core proteasome.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (8) 1 citation
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in meiotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteasomal protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of meiosis I	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome core complex, alpha-subunit complex	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome core complex, alpha-subunit complex	ISS Inferred from Sequence or Structural Similarity more info
part_of spermatoproteasome complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: proteasome subunit alpha type-8

Names: alpha4s; proteasome (prosome, macropain) subunit, alpha type, 8; proteasome alpha 4 subunit; proteasome alpha 8 subunit

NP_001157081.1

EC 3.4.25.1

NP_001347752.1

EC 3.4.25.1

XP_006526357.1

EC 3.4.25.1

XP_036017186.1

EC 3.4.25.1

XP_036017187.1

EC 3.4.25.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163609.1 → NP_001157081.1 proteasome subunit alpha type-8 isoform 1

See identical proteins and their annotated locations for NP_001157081.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AK010717

Consensus CDS

CCDS50226.1

UniProtKB/Swiss-Prot

Q14A44, Q9CWH6

Related

ENSMUSP00000042590.2, ENSMUST00000040860.3

Conserved Domains (2) summary

PRK03996
Location:5 → 235

PRK03996; proteasome subunit alpha; Provisional

cd03755
Location:5 → 213

proteasome_alpha_type_7; proteasome_alpha_type_7. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on ...
NM_001360823.1 → NP_001347752.1 proteasome subunit alpha type-8 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform 2, which is shorter, compared to isoform 1.

Source sequence(s)

AC102692

Consensus CDS

CCDS89194.1

UniProtKB/TrEMBL

B7ZMS4

Related

ENSMUSP00000157022.2, ENSMUST00000234680.2

Conserved Domains (1) summary

cd03755
Location:5 → 173

proteasome_alpha_type_7; proteasome_alpha_type_7. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

14839192..14895358

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006526294.4 → XP_006526357.1 proteasome subunit alpha type-8 isoform X1

See identical proteins and their annotated locations for XP_006526357.1

UniProtKB/TrEMBL

B7ZMS3

Conserved Domains (1) summary

cl00467
Location:1 → 141

Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...
XM_036161293.1 → XP_036017186.1 proteasome subunit alpha type-8 isoform X1

UniProtKB/TrEMBL

B7ZMS3

Conserved Domains (1) summary

cl00467
Location:1 → 141

Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...
XM_036161294.1 → XP_036017187.1 proteasome subunit alpha type-8 isoform X2

Conserved Domains (1) summary

cd03755
Location:5 → 159

proteasome_alpha_type_7; The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming ...