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Capn9 calpain 9 [ Mus musculus (house mouse) ]

Gene ID: 73647, updated on 26-Sep-2022

Summary

Official Symbol
Capn9provided by MGI
Official Full Name
calpain 9provided by MGI
Primary source
MGI:MGI:1920897
See related
Ensembl:ENSMUSG00000031981 AllianceGenome:MGI:1920897
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GC36; nCL4; nCL-4; 2200003B16Rik
Summary
Predicted to enable calcium-dependent cysteine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in stomach cancer. Orthologous to human CAPN9 (calpain 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in stomach adult (RPKM 25.5), colon adult (RPKM 12.1) and 3 other tissues See more
Orthologs
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Genomic context

See Capn9 in Genome Data Viewer
Location:
8; 8 E2
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (125301361..125345470)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (124576062..124618731)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene component of oligomeric golgi complex 2 Neighboring gene angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Neighboring gene RIKEN cDNA 2310022B05 gene Neighboring gene VISTA enhancer mm1665 Neighboring gene tetratricopeptide repeat domain 13 Neighboring gene predicted gene, 46058

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables calcium-dependent cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in digestion IEA
Inferred from Electronic Annotation
more info
 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
calpain-9
Names
digestive tract-specific calpain
new calpain 4
NP_076198.2
XP_006531467.1
XP_006531468.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023709.4NP_076198.2  calpain-9

    See identical proteins and their annotated locations for NP_076198.2

    Status: VALIDATED

    Source sequence(s)
    AC135015, AK008629, BE944051
    Consensus CDS
    CCDS40514.1
    UniProtKB/Swiss-Prot
    O35919, Q9D805
    Related
    ENSMUSP00000090717.6, ENSMUST00000093033.6
    Conserved Domains (4) summary
    cd00051
    Location:566621
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00648
    Location:43335
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:349491
    Calpain_III; Calpain large subunit, domain III
    pfam13499
    Location:597652
    EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    125301361..125345470
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531404.3XP_006531467.1  calpain-9 isoform X1

    Conserved Domains (4) summary
    cd00214
    Location:347496
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
    cd15897
    Location:523550
    EFh_PEF; EF-hand motif [structural motif]
    cl25352
    Location:523718
    EFh_PEF; The penta-EF hand (PEF) family
    pfam00648
    Location:43335
    Peptidase_C2; Calpain family cysteine protease
  2. XM_006531405.3XP_006531468.1  calpain-9 isoform X2

    Conserved Domains (4) summary
    cd00214
    Location:234383
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
    cd15897
    Location:410437
    EFh_PEF; EF-hand motif [structural motif]
    cl25352
    Location:410605
    EFh_PEF; The penta-EF hand (PEF) family
    pfam00648
    Location:43222
    Peptidase_C2; Calpain family cysteine protease