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UGP2 UDP-glucose pyrophosphorylase 2 [ Homo sapiens (human) ]

Gene ID: 7360, updated on 12-Oct-2019

Summary

Official Symbol
UGP2provided by HGNC
Official Full Name
UDP-glucose pyrophosphorylase 2provided by HGNC
Primary source
HGNC:HGNC:12527
See related
Ensembl:ENSG00000169764 MIM:191760
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UDPG; UGP1; UDPGP; UGPP1; UGPP2; SVUGP2; UDPGP2; pHC379
Summary
The enzyme encoded by this gene is an important intermediary in mammalian carbohydrate interconversions. It transfers a glucose moiety from glucose-1-phosphate to MgUTP and forms UDP-glucose and MgPPi. In liver and muscle tissue, UDP-glucose is a direct precursor of glycogen; in lactating mammary gland it is converted to UDP-galactose which is then converted to lactose. The eukaryotic enzyme has no significant sequence similarity to the prokaryotic enzyme. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in liver (RPKM 142.1), fat (RPKM 136.8) and 25 other tissues See more
Orthologs

Genomic context

See UGP2 in Genome Data Viewer
Location:
2p15
Exon count:
16
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (63840964..63891562)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (64068084..64118696)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene citrate synthase pseudogene Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 66 Neighboring gene VPS54 subunit of GARP complex Neighboring gene pellino E3 ubiquitin protein ligase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
UTP:glucose-1-phosphate uridylyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
UTP:glucose-1-phosphate uridylyltransferase activity TAS
Traceable Author Statement
more info
PubMed 
glucose binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
pyrimidine ribonucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
UDP-glucose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
UDP-glucuronate biosynthetic process TAS
Traceable Author Statement
more info
 
glucose 1-phosphate metabolic process IEA
Inferred from Electronic Annotation
more info
 
glycogen biosynthetic process TAS
Traceable Author Statement
more info
 
glycogen metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
nucleus HDA PubMed 

General protein information

Preferred Names
UTP--glucose-1-phosphate uridylyltransferase
Names
UDP-glucose diphosphorylase
UDP-glucose pyrophosphorylase 1
UGPase 2
UTP--glucose-1-phosphate uridylyltransferase 2
UTP-glucose-1-phosphate uridyltransferase
Uridyl diphosphate glucose pyrophosphorylase-1
testis tissue sperm-binding protein Li 58p
uridyl diphosphate glucose pyrophosphorylase 2
NP_001001521.1
NP_006750.3
XP_005264594.1
XP_005264595.1
XP_006712151.1
XP_011531393.1
XP_016860344.1
XP_016860345.1
XP_016860346.1
XP_024308888.1
XP_024308889.1
XP_024308890.1
XP_024308891.1
XP_024308892.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001521.1NP_001001521.1  UTP--glucose-1-phosphate uridylyltransferase isoform b

    See identical proteins and their annotated locations for NP_001001521.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding region compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    BC002954, CD516624
    Consensus CDS
    CCDS42690.1
    UniProtKB/Swiss-Prot
    Q16851
    UniProtKB/TrEMBL
    A0A140VKE1
    Related
    ENSP00000377939.2, ENST00000394417.6
    Conserved Domains (1) summary
    pfam01704
    Location:46462
    UDPGP; UTP--glucose-1-phosphate uridylyltransferase
  2. NM_006759.3NP_006750.3  UTP--glucose-1-phosphate uridylyltransferase isoform a

    See identical proteins and their annotated locations for NP_006750.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    BC000173, BC002954, CA389301
    Consensus CDS
    CCDS1875.1
    UniProtKB/Swiss-Prot
    Q16851
    Related
    ENSP00000338703.5, ENST00000337130.9
    Conserved Domains (1) summary
    pfam01704
    Location:57473
    UDPGP; UTP--glucose-1-phosphate uridylyltransferase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    63840964..63891562
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005264538.2XP_005264595.1  UTP--glucose-1-phosphate uridylyltransferase isoform X1

    See identical proteins and their annotated locations for XP_005264595.1

    UniProtKB/Swiss-Prot
    Q16851
    UniProtKB/TrEMBL
    A0A140VKE1
    Related
    ENSP00000420793.2, ENST00000467648.6
    Conserved Domains (1) summary
    pfam01704
    Location:46462
    UDPGP; UTP--glucose-1-phosphate uridylyltransferase
  2. XM_017004857.2XP_016860346.1  UTP--glucose-1-phosphate uridylyltransferase isoform X2

    Conserved Domains (1) summary
    pfam01704
    Location:1353
    UDPGP; UTP--glucose-1-phosphate uridylyltransferase
  3. XM_006712088.2XP_006712151.1  UTP--glucose-1-phosphate uridylyltransferase isoform X2

    See identical proteins and their annotated locations for XP_006712151.1

    Conserved Domains (1) summary
    pfam01704
    Location:1353
    UDPGP; UTP--glucose-1-phosphate uridylyltransferase
  4. XM_017004855.2XP_016860344.1  UTP--glucose-1-phosphate uridylyltransferase isoform X2

    Conserved Domains (1) summary
    pfam01704
    Location:1353
    UDPGP; UTP--glucose-1-phosphate uridylyltransferase
  5. XM_011533091.1XP_011531393.1  UTP--glucose-1-phosphate uridylyltransferase isoform X2

    See identical proteins and their annotated locations for XP_011531393.1

    Conserved Domains (1) summary
    pfam01704
    Location:1353
    UDPGP; UTP--glucose-1-phosphate uridylyltransferase
  6. XM_024453121.1XP_024308889.1  UTP--glucose-1-phosphate uridylyltransferase isoform X2

    Conserved Domains (1) summary
    pfam01704
    Location:1353
    UDPGP; UTP--glucose-1-phosphate uridylyltransferase
  7. XM_017004856.1XP_016860345.1  UTP--glucose-1-phosphate uridylyltransferase isoform X2

    Conserved Domains (1) summary
    pfam01704
    Location:1353
    UDPGP; UTP--glucose-1-phosphate uridylyltransferase
  8. XM_005264537.3XP_005264594.1  UTP--glucose-1-phosphate uridylyltransferase isoform X1

    See identical proteins and their annotated locations for XP_005264594.1

    UniProtKB/Swiss-Prot
    Q16851
    UniProtKB/TrEMBL
    A0A140VKE1
    Conserved Domains (1) summary
    pfam01704
    Location:46462
    UDPGP; UTP--glucose-1-phosphate uridylyltransferase
  9. XM_024453122.1XP_024308890.1  UTP--glucose-1-phosphate uridylyltransferase isoform X2

    Conserved Domains (1) summary
    pfam01704
    Location:1353
    UDPGP; UTP--glucose-1-phosphate uridylyltransferase
  10. XM_024453120.1XP_024308888.1  UTP--glucose-1-phosphate uridylyltransferase isoform X1

    Related
    ENSP00000411803.2, ENST00000445915.6
    Conserved Domains (1) summary
    pfam01704
    Location:46462
    UDPGP; UTP--glucose-1-phosphate uridylyltransferase
  11. XM_024453123.1XP_024308891.1  UTP--glucose-1-phosphate uridylyltransferase isoform X2

    Conserved Domains (1) summary
    pfam01704
    Location:1353
    UDPGP; UTP--glucose-1-phosphate uridylyltransferase
  12. XM_024453124.1XP_024308892.1  UTP--glucose-1-phosphate uridylyltransferase isoform X2

    Conserved Domains (1) summary
    pfam01704
    Location:1353
    UDPGP; UTP--glucose-1-phosphate uridylyltransferase
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