Camkmt calmodulin-lysine N-methyltransferase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Camkmtprovided by MGI
Official Full Name: calmodulin-lysine N-methyltransferaseprovided by MGI
Primary source: MGI:MGI:1920832
See related: Ensembl:ENSMUSG00000071037 AllianceGenome:MGI:1920832
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CLNMT; CaM KMT; 1700106N22Rik
Summary: Enables calmodulin-lysine N-methyltransferase activity. Acts upstream of or within mitochondrion organization and peptidyl-lysine methylation. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of protein-containing complex. Is expressed in maxillary process. Used to study hypotonia-cystinuria syndrome. Orthologous to human CAMKMT (calmodulin-lysine N-methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in cerebellum adult (RPKM 1.2), testis adult (RPKM 0.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17; 17 E4

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (85397989..85766017)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (85090561..85458589)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CaM methylation appears to have a role in growth, muscle strength, somatosensory development and brain function.
Title: Calmodulin Methyltransferase Is Required for Growth, Muscle Strength, Somatosensory Development and Brain Function.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D17Mit189 (e-PCR), detects polymorphism
- UniSTS:116483

AI480743 (e-PCR)
- UniSTS:186117

D17Mit210 (e-PCR), detects polymorphism
- UniSTS:128024

NoName (e-PCR)
- UniSTS:490649

UniSTS:237721 (e-PCR)
- UniSTS:237721

NoName (e-PCR)
- UniSTS:495808

Homology

Homologs of the Camkmt gene: The Camkmt gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, A.thaliana, and frog.
Orthologs from Annotation Pipeline: 483 organisms have orthologs with human gene Camkmt
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calmodulin-lysine N-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables calmodulin-lysine N-methyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables heat shock protein binding	ISO Inferred from Sequence Orthology more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within methylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within peptidyl-lysine methylation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: calmodulin-lysine N-methyltransferase

NP_001351875.1

EC 2.1.1.60

NP_082852.1

EC 2.1.1.60

XP_006525055.1

EC 2.1.1.60

XP_006525056.1

EC 2.1.1.60

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001364946.1 → NP_001351875.1 calmodulin-lysine N-methyltransferase isoform 2

Status: VALIDATED

Source sequence(s)

AC113476, BB621809, BQ175501, CN533503
NM_028576.3 → NP_082852.1 calmodulin-lysine N-methyltransferase isoform 1

See identical proteins and their annotated locations for NP_082852.1

Status: VALIDATED

Source sequence(s)

AC113476, AC154217, AC154475

Consensus CDS

CCDS37712.1

UniProtKB/Swiss-Prot

Q3U2J5, Q9D9C5

UniProtKB/TrEMBL

B9EHP1

Related

ENSMUSP00000092811.6, ENSMUST00000095188.7

Conserved Domains (1) summary

cl17173
Location:113 → 278

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

85397989..85766017

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006524992.3 → XP_006525055.1 calmodulin-lysine N-methyltransferase isoform X1

See identical proteins and their annotated locations for XP_006525055.1

Conserved Domains (1) summary

cl17173
Location:113 → 253

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
XM_006524993.5 → XP_006525056.1 calmodulin-lysine N-methyltransferase isoform X2