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SCGB1A1 secretoglobin family 1A member 1 [ Homo sapiens (human) ]

Gene ID: 7356, updated on 2-Nov-2024

Summary

Official Symbol
SCGB1A1provided by HGNC
Official Full Name
secretoglobin family 1A member 1provided by HGNC
Primary source
HGNC:HGNC:12523
See related
Ensembl:ENSG00000149021 MIM:192020; AllianceGenome:HGNC:12523
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UGB; UP1; CC10; CC16; CCSP; UP-1; CCPBP
Summary
This gene encodes a member of the secretoglobin family of small secreted proteins. The encoded protein has been implicated in numerous functions including anti-inflammation, inhibition of phospholipase A2 and the sequestering of hydrophobic ligands. Defects in this gene are associated with a susceptibility to asthma. [provided by RefSeq, May 2010]
Expression
Restricted expression toward lung (RPKM 1367.3) See more
Orthologs
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Genomic context

See SCGB1A1 in Genome Data Viewer
Location:
11q12.3
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (62419033..62423195)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (62408482..62412645)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (62186505..62190667)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene asparaginase and isoaspartyl peptidase 1 Neighboring gene uncharacterized LOC124902682 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62138707-62139229 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62138184-62138706 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62149617-62150182 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62150183-62150748 Neighboring gene regulator of chromosome condensation 2 pseudogene 6 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4813 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4814 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:62164057-62164558 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:62164559-62165058 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62165726-62166370 Neighboring gene uncharacterized LOC102723765 Neighboring gene Sharpr-MPRA regulatory region 15173 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4815 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4816 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62193633-62194180 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:62201545-62202046 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:62202047-62202546 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4817 Neighboring gene Sharpr-MPRA regulatory region 7741 Neighboring gene AHNAK nucleoprotein Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:62273135-62273882 Neighboring gene Sharpr-MPRA regulatory region 266 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:62302796-62303995 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:62306574-62307176 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:62307177-62307777 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4818 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4819 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62312785-62313295 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62313296-62313806 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3414 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3415 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62314385-62314915 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62318643-62319448 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62319449-62320254 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3416 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62323477-62324282 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62324283-62325086 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:62325319-62325834 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:62326954-62327496 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4824 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62329123-62329665 Neighboring gene eukaryotic translation elongation factor 1 gamma Neighboring gene microRNA 6747

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables phospholipase A2 inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables polychlorinated biphenyl binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in embryo implantation TAS
Traceable Author Statement
more info
PubMed 
involved_in female pregnancy NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of interleukin-13 production IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of interleukin-4 production IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of interleukin-5 production IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of type II interferon production IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of mRNA stability IEA
Inferred from Electronic Annotation
more info
 
involved_in response to cytokine IEA
Inferred from Electronic Annotation
more info
 
involved_in response to fibroblast growth factor IEA
Inferred from Electronic Annotation
more info
 
involved_in response to glucocorticoid IEA
Inferred from Electronic Annotation
more info
 
involved_in response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
involved_in response to ozone IEA
Inferred from Electronic Annotation
more info
 
involved_in response to silicon dioxide IEA
Inferred from Electronic Annotation
more info
 
involved_in response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular exosome HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear envelope IEA
Inferred from Electronic Annotation
more info
 
located_in secretory granule IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
uteroglobin
Names
Uteroglobin (club-cell specific 10-kD protein)
blastokinin
club cell 10 kDa secretory protein
club cell phospholipid-binding protein
club cell protein 16
club cells 10 kDa secretory protein
club secretory protein 16
secretoglobin, family 1A, member 1 (uteroglobin)
urinary protein 1
urine protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021331.1 RefSeqGene

    Range
    4999..9161
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003357.5NP_003348.1  uteroglobin precursor

    See identical proteins and their annotated locations for NP_003348.1

    Status: REVIEWED

    Source sequence(s)
    AK312165, AP003064, BC004481
    Consensus CDS
    CCDS8020.1
    UniProtKB/Swiss-Prot
    B2R5F2, P11684, Q6FHH3, Q9UCM2, Q9UCM4
    UniProtKB/TrEMBL
    A0A0S2Z4R6
    Related
    ENSP00000278282.2, ENST00000278282.3
    Conserved Domains (1) summary
    smart00096
    Location:2290
    UTG; Uteroglobin

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    62419033..62423195
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    62408482..62412645
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)