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SCGB1A1 secretoglobin family 1A member 1 [ Homo sapiens (human) ]

Gene ID: 7356, updated on 3-Oct-2021

Summary

Official Symbol
SCGB1A1provided by HGNC
Official Full Name
secretoglobin family 1A member 1provided by HGNC
Primary source
HGNC:HGNC:12523
See related
Ensembl:ENSG00000149021 MIM:192020
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UGB; UP1; CC10; CC16; CCSP; UP-1; CCPBP
Summary
This gene encodes a member of the secretoglobin family of small secreted proteins. The encoded protein has been implicated in numerous functions including anti-inflammation, inhibition of phospholipase A2 and the sequestering of hydrophobic ligands. Defects in this gene are associated with a susceptibility to asthma. [provided by RefSeq, May 2010]
Expression
Restricted expression toward lung (RPKM 1367.3) See more
Orthologs
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Genomic context

See SCGB1A1 in Genome Data Viewer
Location:
11q12.3
Exon count:
3
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (62419033..62423195)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (62186505..62190667)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene asparaginase and isoaspartyl peptidase 1 Neighboring gene regulator of chromosome condensation 2 pseudogene 6 Neighboring gene uncharacterized LOC107984335 Neighboring gene uncharacterized LOC102723765 Neighboring gene AHNAK nucleoprotein Neighboring gene eukaryotic translation elongation factor 1 gamma Neighboring gene microRNA 6747

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables phospholipase A2 inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables polychlorinated biphenyl binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in embryo implantation TAS
Traceable Author Statement
more info
PubMed 
involved_in female pregnancy NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of interferon-gamma production IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of interleukin-13 production IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of interleukin-4 production IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of interleukin-5 production IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of mRNA stability IEA
Inferred from Electronic Annotation
more info
 
involved_in response to cytokine IEA
Inferred from Electronic Annotation
more info
 
involved_in response to fibroblast growth factor IEA
Inferred from Electronic Annotation
more info
 
involved_in response to glucocorticoid IEA
Inferred from Electronic Annotation
more info
 
involved_in response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
involved_in response to ozone IEA
Inferred from Electronic Annotation
more info
 
involved_in response to silicon dioxide IEA
Inferred from Electronic Annotation
more info
 
involved_in response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular exosome HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear envelope IEA
Inferred from Electronic Annotation
more info
 
located_in rough endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in secretory granule IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
uteroglobin
Names
blastokinin
clara cell phospholipid-binding protein
clara cells 10 kDa secretory protein
secretoglobin, family 1A, member 1 (uteroglobin)
urinary protein 1
urine protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021331.1 RefSeqGene

    Range
    4999..9161
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003357.5NP_003348.1  uteroglobin precursor

    See identical proteins and their annotated locations for NP_003348.1

    Status: REVIEWED

    Source sequence(s)
    AK312165, AP003064, BC004481
    Consensus CDS
    CCDS8020.1
    UniProtKB/Swiss-Prot
    P11684
    UniProtKB/TrEMBL
    A0A0S2Z4R6
    Related
    ENSP00000278282.2, ENST00000278282.3
    Conserved Domains (1) summary
    smart00096
    Location:2290
    UTG; Uteroglobin

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    62419033..62423195
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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