faslg Fas ligand (TNF superfamily, member 6) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: faslgprovided by ZNC
Official Full Name: Fas ligand (TNF superfamily, member 6)provided by ZNC
Primary source: ZFIN:ZDB-GENE-070410-16
See related: Ensembl:ENSDARG00000098913 AllianceGenome:ZFIN:ZDB-GENE-070410-16
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fasl; zgc:162027
Summary: Predicted to enable cytokine activity. Acts upstream of or within notochord development. Predicted to be located in membrane. Predicted to be active in extracellular space. Is expressed in brain; digestive system; eye; notochord; and ovary. Human ortholog(s) of this gene implicated in several diseases, including cholangiocarcinoma; chronic myeloid leukemia; diabetes mellitus (multiple); pancreatic cancer (multiple); and pre-eclampsia (multiple). Orthologous to human FASLG (Fas ligand). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	20	NC_133195.1 (16830038..16834625)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (15600425..15605013)

Chromosome 20 - NC_133195.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables tumor necrosis factor receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in extrinsic apoptotic signaling pathway via death domain receptors	IBA Inferred from Biological aspect of Ancestor more info
involved_in extrinsic apoptotic signaling pathway via death domain receptors	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within notochord development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within notochord development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of extrinsic apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasmic vesicle lumen	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in lysosomal lumen	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tumor necrosis factor ligand superfamily member 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001042701.2 → NP_001036166.1 tumor necrosis factor ligand superfamily member 6

See identical proteins and their annotated locations for NP_001036166.1

Status: PROVISIONAL

Source sequence(s)

BC133842

UniProtKB/TrEMBL

A4FVG4, Q0PKX7

Related

ENSDARP00000136343.1, ENSDART00000171991.2

Conserved Domains (2) summary

cd00184
Location:129 → 265

TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...

cl14909
Location:64 → 149

GspL_C; GspL periplasmic domain