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rpl22l1 ribosomal protein L22-like 1 [ Danio rerio (zebrafish) ]

Gene ID: 735250, updated on 4-Jan-2025

Summary

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Official Symbol
rpl22l1provided by ZNC
Official Full Name
ribosomal protein L22-like 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-060804-3
See related
Ensembl:ENSDARG00000010244 AllianceGenome:ZFIN:ZDB-GENE-060804-3
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fa96f07; wu:fa96f07; zgc:136591
Summary
Enables pre-mRNA binding activity. Involved in regulation of mRNA cis splicing, via spliceosome. Acts upstream of or within convergent extension involved in axis elongation and definitive hemopoiesis. Is active in nucleus. Is expressed in intermediate cell mass of mesoderm. Orthologous to human RPL22L1 (ribosomal protein L22 like 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See rpl22l1 in Genome Data Viewer
Location:
chromosome: 24
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (26475182..26479835, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (26330141..26334794, complement)

Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene claudin 11b Neighboring gene solute carrier family 7 member 14b Neighboring gene eukaryotic translation initiation factor 5A Neighboring gene TRAF2 and NCK interacting kinase b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Inhibition of Embryonic HSP 90 Function Promotes Variation of Cold Tolerance in Zebrafish. Han B, et al. Front Genet, 2020. PMID 33343615, Free PMC Article
  2. Pervasive changes of mRNA splicing in upf1-deficient zebrafish identify rpl10a as a regulator of T cell development. Lawir DF, et al. Proc Natl Acad Sci U S A, 2020 Jul 7. PMID 32571908, Free PMC Article
  3. A Pilot Single Cell Analysis of the Zebrafish Embryo Cellular Responses to Uropathogenic Escherichia coli Infection. Rawson A, et al. Pathog Immun, 2022. PMID 35178490, Free PMC Article
  4. Control of hematopoietic stem cell emergence by antagonistic functions of ribosomal protein paralogs. Zhang Y, et al. Dev Cell, 2013 Feb 25. PMID 23449473, Free PMC Article
  5. Transcriptome analysis reveals a ribosome constituents disorder involved in the RPL5 downregulated zebrafish model of Diamond-Blackfan anemia. Wan Y, et al. BMC Med Genomics, 2016 Mar 9. PMID 26961822, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rpl22, and its highly homologous paralog Rpl22-Like1 (Rpl22l1 or Like1) play critical, extraribosomal roles in embryogenesis.
    Title: Ribosomal Proteins Rpl22 and Rpl22l1 Control Morphogenesis by Regulating Pre-mRNA Splicing.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables pre-mRNA binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within convergent extension involved in axis elongation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within convergent extension involved in axis elongation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within definitive hemopoiesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mRNA cis splicing, via spliceosome IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of mRNA cis splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ribosomal protein eL22-like
NP_001038800.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001045335.2 → NP_001038800.1  ribosomal protein eL22-like

    See identical proteins and their annotated locations for NP_001038800.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript.
    Source sequence(s)
    BC118681, EH565022
    UniProtKB/TrEMBL
    A0A8M1NAG4, Q0VFW0
    Related
    ENSDARP00000074434.5, ENSDART00000079984.7
    Conserved Domains (1) summary
    pfam01776
    Location:18 → 120
    Ribosomal_L22e; Ribosomal L22e protein family

RNA

  1. NR_027625.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC118681, BC122324, CR354583
    Related
    ENSDART00000136871.3

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007135.7 Reference GRCz11 Primary Assembly

    Range
    26475182..26479835 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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