U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

selenos selenoprotein S [ Danio rerio (zebrafish) ]

Gene ID: 735249, updated on 11-Apr-2024

Summary

Official Symbol
selenosprovided by ZNC
Official Full Name
selenoprotein Sprovided by ZNC
Primary source
ZFIN:ZDB-GENE-060804-1
See related
Ensembl:ENSDARG00000070097 AllianceGenome:ZFIN:ZDB-GENE-060804-1
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
sels; vimp; wu:fc16a03; zgc:136970
Summary
This gene encodes a transmembrane protein that is localized in the endoplasmic reticulum (ER). It is involved in the degradation process of misfolded proteins in the ER, and may also have a role in inflammation control in higher eukaryotes. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs in vertebrates contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, Aug 2017]
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See selenos in Genome Data Viewer
Location:
chromosome: 7
Exon count:
6
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (9308606..9322622)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (9063123..9077006)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene proprotein convertase subtilisin/kexin type 6 Neighboring gene small nuclear ribonucleoprotein polypeptide A' Neighboring gene chondroitin sulfate synthase 1 Neighboring gene leucine-rich repeat kinase 1

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
involved_in endoplasmic reticulum unfolded protein response IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in retrograde protein transport, ER to cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of Derlin-1 retrotranslocation complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of Derlin-1-VIMP complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic microtubule ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
selenoprotein S
Names
VCP-interacting membrane protein
VCP-interacting membrane selenoprotein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001045334.3NP_001038799.2  selenoprotein S

    See identical proteins and their annotated locations for NP_001038799.2

    Status: REVIEWED

    Source sequence(s)
    CU856378
    UniProtKB/Swiss-Prot
    Q0VFV6
    Related
    ENSDARP00000079033.6, ENSDART00000084598.6
    Conserved Domains (1) summary
    pfam06936
    Location:1188
    Selenoprotein_S; Selenoprotein S (SelS)

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    9308606..9322622
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)