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UCP2 uncoupling protein 2 [ Homo sapiens (human) ]

Gene ID: 7351, updated on 8-Dec-2018

Summary

Official Symbol
UCP2provided by HGNC
Official Full Name
uncoupling protein 2provided by HGNC
Primary source
HGNC:HGNC:12518
See related
Ensembl:ENSG00000175567 MIM:601693
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UCPH; BMIQ4; SLC25A8
Summary
Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'. [provided by RefSeq, Jul 2008]
Expression
Broad expression in lymph node (RPKM 136.6), spleen (RPKM 105.7) and 20 other tissues See more
Orthologs

Genomic context

See UCP2 in Genome Data Viewer
Location:
11q13.4
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (73974671..73982872, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (73685716..73693889, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene proteasomal ATPase associated factor 1 Neighboring gene actin related protein 2/3 complex subunit 3 pseudogene 4 Neighboring gene DnaJ heat shock protein family (Hsp40) member B13 Neighboring gene developmental pluripotency associated 4 pseudogene Neighboring gene family with sequence similarity 91 member A1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
oxidative phosphorylation uncoupler activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
adaptive thermogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
aging IEA
Inferred from Electronic Annotation
more info
 
cellular response to amino acid starvation IEA
Inferred from Electronic Annotation
more info
 
cellular response to glucose stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to insulin stimulus IEA
Inferred from Electronic Annotation
more info
 
female pregnancy IEA
Inferred from Electronic Annotation
more info
 
liver regeneration IEA
Inferred from Electronic Annotation
more info
 
mitochondrial transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of insulin secretion involved in cellular response to glucose stimulus IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell death IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
proton transmembrane transport TAS
Traceable Author Statement
more info
 
regulation of mitochondrial membrane potential IEA
Inferred from Electronic Annotation
more info
 
response to cold IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to fatty acid IEA
Inferred from Electronic Annotation
more info
 
response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
response to superoxide IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
mitochondrial uncoupling protein 2
Names
solute carrier family 25 member 8
uncoupling protein 2 (mitochondrial, proton carrier)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011478.1 RefSeqGene

    Range
    5001..13174
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003355.2NP_003346.2  mitochondrial uncoupling protein 2

    See identical proteins and their annotated locations for NP_003346.2

    Status: REVIEWED

    Source sequence(s)
    AF096289
    Consensus CDS
    CCDS8228.1
    UniProtKB/Swiss-Prot
    P55851
    UniProtKB/TrEMBL
    A0A024R5N5
    Related
    ENSP00000312029.3, ENST00000310473.7
    Conserved Domains (1) summary
    pfam00153
    Location:112206
    Mito_carr; Mitochondrial carrier protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    73974671..73982872 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448674.1XP_024304442.1  mitochondrial uncoupling protein 2 isoform X1

    Related
    ENSP00000439951.1, ENST00000544615.5
    Conserved Domains (2) summary
    pfam00153
    Location:113207
    Mito_carr; Mitochondrial carrier protein
    cl28162
    Location:42112
    Mito_carr; Mitochondrial carrier protein
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