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UCP1 uncoupling protein 1 [ Homo sapiens (human) ]

Gene ID: 7350, updated on 12-Aug-2018

Summary

Official Symbol
UCP1provided by HGNC
Official Full Name
uncoupling protein 1provided by HGNC
Primary source
HGNC:HGNC:12517
See related
Ensembl:ENSG00000109424 MIM:113730; Vega:OTTHUMG00000133415
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UCP; SLC25A7
Summary
Mitochondrial uncoupling proteins (UCP) are members of the family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See UCP1 in Genome Data Viewer
Location:
4q31.1
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 4 NC_000004.12 (140555770..140568914, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (141481014..141489989, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene MGAT4 family member D Neighboring gene ELMO domain containing 2 Neighboring gene RNA, 7SL, cytoplasmic 152, pseudogene Neighboring gene TBC1 domain family member 9 Neighboring gene trinucleotide repeat containing 18 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Adipogenesis, organism-specific biosystem (from WikiPathways)
    Adipogenesis, organism-specific biosystemThe different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compo...
  • Apelin signaling pathway, organism-specific biosystem (from KEGG)
    Apelin signaling pathway, organism-specific biosystemApelin is an endogenous peptide capable of binding the apelin receptor (APJ), which was originally described as an orphan G-protein-coupled receptor. Apelin and APJ are widely expressed in various ti...
  • Electron Transport Chain, organism-specific biosystem (from WikiPathways)
    Electron Transport Chain, organism-specific biosystemAn electron transport chain(ETC) couples a chemical reaction between an electron donor (such as NADH) and an electron acceptor (such as O2) to the transfer of H+ ions across a membrane, through a set...
  • FTO Obesity Variant Mechanism, organism-specific biosystem (from WikiPathways)
    FTO Obesity Variant Mechanism, organism-specific biosystemMechanism underlying the association of FTO locus variants and obesity. The wild type T allele at rs1421085 in the FTO locus comprises a protein-DNA binding motif for ARID5B that represses the transc...
  • Huntington's disease, organism-specific biosystem (from KEGG)
    Huntington's disease, organism-specific biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
  • Huntington's disease, conserved biosystem (from KEGG)
    Huntington's disease, conserved biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Mitochondrial Uncoupling Proteins, organism-specific biosystem (from REACTOME)
    Mitochondrial Uncoupling Proteins, organism-specific biosystemUncoupling proteins (UCPs) are members of the mitochondrial transport carrier family, and have been implicated in a wide range of physiological and pathological conditions. Physiological conditions i...
  • PPAR signaling pathway, organism-specific biosystem (from KEGG)
    PPAR signaling pathway, organism-specific biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
  • PPAR signaling pathway, conserved biosystem (from KEGG)
    PPAR signaling pathway, conserved biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
  • Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins., organism-specific biosystem (from REACTOME)
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins., organism-specific biosystemOxidation of fatty acids and pyruvate in the mitochondrial matrix yield large amounts of NADH. The respiratory electron transport chain couples the re-oxidation of this NADH to NAD+ to the export of ...
  • The citric acid (TCA) cycle and respiratory electron transport, organism-specific biosystem (from REACTOME)
    The citric acid (TCA) cycle and respiratory electron transport, organism-specific biosystemThe metabolism of pyruvate provides one source of acetyl-CoA which enters the citric acid (TCA, tricarboxylic acid) cycle to generate energy and the reducing equivalent NADH. These reducing equivalen...
  • The fatty acid cycling model, organism-specific biosystem (from REACTOME)
    The fatty acid cycling model, organism-specific biosystemThe "fatty acid cycling" hypothesis proposes that protonated fatty acids flip-flop in the membrane and deliver a proton to the matrix side. UCP1 catalyses the return of the fatty acid anion to the cy...
  • The proton buffering model, organism-specific biosystem (from REACTOME)
    The proton buffering model, organism-specific biosystemThe "proton buffering" model proposes that UCP1 is intrinsically a proton carrier, and that fatty acid acts as a prosthetic group during proton transport. Fatty acid penetrates from the lipid phase, ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cardiolipin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
long-chain fatty acid binding ISS
Inferred from Sequence or Structural Similarity
more info
 
oxidative phosphorylation uncoupler activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxidative phosphorylation uncoupler activity ISS
Inferred from Sequence or Structural Similarity
more info
 
purine ribonucleotide binding ISS
Inferred from Sequence or Structural Similarity
more info
 
transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
adaptive thermogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adaptive thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
brown fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to fatty acid ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to hormone stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to reactive oxygen species ISS
Inferred from Sequence or Structural Similarity
more info
 
diet induced thermogenesis IEA
Inferred from Electronic Annotation
more info
 
mitochondrial transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
proton transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
proton transmembrane transport TAS
Traceable Author Statement
more info
 
regulation of reactive oxygen species biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
response to cold IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to nutrient levels ISS
Inferred from Sequence or Structural Similarity
more info
 
response to temperature stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
mitochondrial brown fat uncoupling protein 1
Names
solute carrier family 25 member 7
thermogenin
uncoupling protein 1 (mitochondrial, proton carrier)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012139.1 RefSeqGene

    Range
    5001..13910
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_021833.4NP_068605.1  mitochondrial brown fat uncoupling protein 1

    See identical proteins and their annotated locations for NP_068605.1

    Status: REVIEWED

    Source sequence(s)
    BC098258
    Consensus CDS
    CCDS3753.1
    UniProtKB/Swiss-Prot
    P25874
    Related
    ENSP00000262999.3, OTTHUMP00000164611, ENST00000262999.3, OTTHUMT00000257273
    Conserved Domains (1) summary
    pfam00153
    Location:111206
    Mito_carr; Mitochondrial carrier protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p12 Primary Assembly

    Range
    140555770..140568914 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005263206.3XP_005263263.1  mitochondrial brown fat uncoupling protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005263263.1

    UniProtKB/TrEMBL
    Q4KMT7
    Conserved Domains (1) summary
    pfam00153
    Location:108205
    Mito_carr; Mitochondrial carrier protein
  2. XM_011532228.2XP_011530530.1  mitochondrial brown fat uncoupling protein 1 isoform X2

    Conserved Domains (1) summary
    pfam00153
    Location:111206
    Mito_carr; Mitochondrial carrier protein
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