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UCP1 uncoupling protein 1 [ Homo sapiens (human) ]

Gene ID: 7350, updated on 6-Sep-2021

Summary

Official Symbol
UCP1provided by HGNC
Official Full Name
uncoupling protein 1provided by HGNC
Primary source
HGNC:HGNC:12517
See related
Ensembl:ENSG00000109424 MIM:113730
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UCP; SLC25A7
Summary
Mitochondrial uncoupling proteins (UCP) are members of the family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See UCP1 in Genome Data Viewer
Location:
4q31.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (140555770..140568961, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (141480585..141490115, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene MGAT4 family member D Neighboring gene ELMO domain containing 2 Neighboring gene RNA, 7SL, cytoplasmic 152, pseudogene Neighboring gene TBC1 domain family member 9 Neighboring gene trinucleotide repeat containing 18 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cardiolipin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables long-chain fatty acid binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables oxidative phosphorylation uncoupler activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables oxidative phosphorylation uncoupler activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables purine ribonucleotide binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in adaptive thermogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in adaptive thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in brown fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to cold IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to fatty acid ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to hormone stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to reactive oxygen species ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in diet induced thermogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in mitochondrial transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitochondrial transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in proton transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of reactive oxygen species biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in response to cold IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to nutrient levels ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to temperature stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
mitochondrial brown fat uncoupling protein 1
Names
solute carrier family 25 member 7
thermogenin
uncoupling protein 1 (mitochondrial, proton carrier)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012139.1 RefSeqGene

    Range
    4845..14375
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_021833.5NP_068605.1  mitochondrial brown fat uncoupling protein 1

    See identical proteins and their annotated locations for NP_068605.1

    Status: REVIEWED

    Source sequence(s)
    AC108019, BC098258
    Consensus CDS
    CCDS3753.1
    UniProtKB/Swiss-Prot
    P25874
    Related
    ENSP00000262999.3, ENST00000262999.4
    Conserved Domains (1) summary
    pfam00153
    Location:111206
    Mito_carr; Mitochondrial carrier protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    140555770..140568961 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005263206.3XP_005263263.1  mitochondrial brown fat uncoupling protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005263263.1

    UniProtKB/TrEMBL
    Q4KMT7
    Conserved Domains (1) summary
    pfam00153
    Location:108205
    Mito_carr; Mitochondrial carrier protein
  2. XM_011532228.2XP_011530530.1  mitochondrial brown fat uncoupling protein 1 isoform X2

    Conserved Domains (1) summary
    pfam00153
    Location:111206
    Mito_carr; Mitochondrial carrier protein
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