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h2axl.S H2AX variant histone like S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 734746, updated on 5-Sep-2025
Official Symbol
h2axl.S
Official Full Name
H2AX variant histone like S homeolog
Primary source
Xenbase:XB-GENE-6493983
Locus tag
XELAEV_18000724mg
See related
EnsemblRapid:ENSXLAG00005003954 AllianceGenome:Xenbase:XB-GENE-6493983
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
h2ax; h2a.x; h2a/x; h2afx; h2afxl; h2afx.L; h2ax.lS
Summary
Predicted to enable DNA binding activity and protein heterodimerization activity. Predicted to be a structural constituent of chromatin. Predicted to be located in chromosome and nucleus. Predicted to be part of nucleosome. [provided by Alliance of Genome Resources, Jul 2025]
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See h2axl.S in Genome Data Viewer
Location:
chromosome: 3S
Exon count:
1
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 3S NC_054376.1 (123468701..123469485, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) Unplaced Scaffold NW_016694811.1 (6754..7358, complement)

Chromosome 3S - NC_054376.1Genomic Context describing neighboring genes Neighboring gene transfer RNA glutamine (anticodon UUG) Neighboring gene histone H4 Neighboring gene histone H2B 1.1 Neighboring gene histone H4

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Histone XH2AX is required for Xenopus anterior neural development: critical role of threonine 16 phosphorylation. Lee SY, et al. J Biol Chem, 2010 Sep 17. PMID 20639511, Free PMC Article
  2. Structural basis of histone H2A lysine 119 deubiquitination by Polycomb Repressive Deubiquitinase BAP1/ASXL1. Thomas JF, et al. bioRxiv, 2023 Feb 23. PMID 36865140, Free PMC Article
  3. Genomic organization and nucleotide sequence of two distinct histone gene clusters from Xenopus laevis. Identification of novel conserved upstream sequence elements. Perry M, et al. J Mol Biol, 1985 Oct 5. PMID 3863963
  4. Structure and Dynamics of a 197 bp Nucleosome in Complex with Linker Histone H1. Bednar J, et al. Mol Cell, 2017 May 4. PMID 28475873, Free PMC Article
  5. Structural evidence for Nap1-dependent H2A-H2B deposition and nucleosome assembly. Aguilar-Gurrieri C, et al. EMBO J, 2016 Jul 1. PMID 27225933, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Findings reveal that XH2AX has a specific role in anterior neural formation of Xenopus, which is mediated through phosphorylation of XH2AX at Thr(16) by Chk1.
    Title: Histone XH2AX is required for Xenopus anterior neural development: critical role of threonine 16 phosphorylation.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Clone Names

  • MGC130860

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of chromatin IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
part_of nucleosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nucleosome IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
histone H2A type 1
Names
H2A histone family member X L homeolog
H2A histone family, member X
H2A.X variant histone-like S homeolog

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001096215.1 → NP_001089684.1  histone H2A type 1

    See identical proteins and their annotated locations for NP_001089684.1

    Status: PROVISIONAL

    Source sequence(s)
    BC106331
    UniProtKB/Swiss-Prot
    P06897, Q3B8I8
    UniProtKB/TrEMBL
    A0A8J1MSH7
    Related
    ENSXLAP00005011848.1, ENSXLAT00005012022.1
    Conserved Domains (1) summary
    PTZ00017
    Location:1 → 130
    PTZ00017; histone H2A; Provisional

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054376.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    123468701..123469485 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P06897.2 GenPept UniProtKB/Swiss-Prot:P06897

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials