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Rnf38 ring finger protein 38 [ Mus musculus (house mouse) ]

Gene ID: 73469, updated on 26-Sep-2022

Summary

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Official Symbol
Rnf38provided by MGI
Official Full Name
ring finger protein 38provided by MGI
Primary source
MGI:MGI:1920719
See related
Ensembl:ENSMUSG00000035696 AllianceGenome:MGI:1920719
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Oip1; 1700065B19Rik; 2610202O07Rik
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. Predicted to be located in nucleoplasm and sperm flagellum. Is expressed in heart; limb; nervous system; and sensory organ. Orthologous to human RNF38 (ring finger protein 38). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 139.9), whole brain E14.5 (RPKM 39.1) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Rnf38 in Genome Data Viewer
Location:
4; 4 B1
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (44126210..44233929, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (44126210..44233905, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase Neighboring gene prothymosin alpha, pseudogene 2 Neighboring gene microRNA 5106 Neighboring gene predicted gene, 54218 Neighboring gene maternal embryonic leucine zipper kinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Novel RING finger protein OIP1 binds to conserved amino acid repeats in sperm tail protein ODF1. Zarsky HA, et al. Biol Reprod, 2003 Feb. PMID 12533418, Free PMC Article
  2. Spatiotemporal gene expression patterns reveal molecular relatedness between retinal laminae. Jiang D, et al. J Comp Neurol, 2020 Apr 1. PMID 31609468, Free PMC Article
  3. Identification and analysis of genes from the mouse otic vesicle and their association with developmental subprocesses through in situ hybridization. Powles N, et al. Dev Biol, 2004 Apr 1. PMID 15031102
  4. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article
  5. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article

See all (23) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in sperm flagellum ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase RNF38
Names
RING-type E3 ubiquitin transferase RNF38
NP_001034082.1
NP_001342110.1
NP_001366503.1
NP_001366504.1
NP_001366505.1
NP_001366506.1
NP_001366507.1
NP_001366508.1
NP_001366509.1
NP_001366510.1
NP_780410.2
XP_006538363.1
XP_006538364.1
XP_006538368.1
XP_011248417.2
XP_011248418.2
XP_011248419.2
XP_030109694.1
XP_036020382.1
XP_036020383.1
XP_036020384.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001038993.5 → NP_001034082.1  E3 ubiquitin-protein ligase RNF38 isoform 2

    See identical proteins and their annotated locations for NP_001034082.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2), as well as variants 3-8, encodes isoform 2.
    Source sequence(s)
    AL732563, AL805952
    Consensus CDS
    CCDS18123.1
    UniProtKB/TrEMBL
    A0A6P5PPH9, Q3UH35
    Related
    ENSMUSP00000038477.9, ENSMUST00000045793.15
    Conserved Domains (1) summary
    cd16472
    Location:377 → 421
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins

  2. NM_001355181.2 → NP_001342110.1  E3 ubiquitin-protein ligase RNF38 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3), as well as variants 2 and 4-8, encodes isoform 2.
    Source sequence(s)
    AL732563, AL805952
    Consensus CDS
    CCDS18123.1
    UniProtKB/TrEMBL
    A0A6P5PPH9, Q3UH35
    Conserved Domains (1) summary
    cd16472
    Location:377 → 421
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins

  3. NM_001379574.1 → NP_001366503.1  E3 ubiquitin-protein ligase RNF38 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variants 2, 3, and 5-8, encodes isoform 2.
    Source sequence(s)
    AL732563, AL805952
    UniProtKB/TrEMBL
    A0A6P5PPH9, Q3UH35
    Conserved Domains (1) summary
    cd16472
    Location:377 → 421
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins

  4. NM_001379575.1 → NP_001366504.1  E3 ubiquitin-protein ligase RNF38 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variants 2-4 and 6-8, encodes isoform 2.
    Source sequence(s)
    AL732563, AL805952
    UniProtKB/TrEMBL
    A0A6P5PPH9, Q3UH35
    Conserved Domains (1) summary
    cd16472
    Location:377 → 421
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins

  5. NM_001379576.1 → NP_001366505.1  E3 ubiquitin-protein ligase RNF38 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variants 2-5, 7, and 8, encodes isoform 2.
    Source sequence(s)
    AL732563, AL805952
    UniProtKB/TrEMBL
    A0A6P5PPH9, Q3UH35
    Conserved Domains (1) summary
    cd16472
    Location:377 → 421
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins

  6. NM_001379577.1 → NP_001366506.1  E3 ubiquitin-protein ligase RNF38 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7), as well as variants 2-6 and 8, encodes isoform 2.
    Source sequence(s)
    AL732563, AL805952
    UniProtKB/TrEMBL
    A0A6P5PPH9, Q3UH35
    Related
    ENSMUSP00000099998.3, ENSMUST00000102934.9
    Conserved Domains (1) summary
    cd16472
    Location:377 → 421
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins

  7. NM_001379578.1 → NP_001366507.1  E3 ubiquitin-protein ligase RNF38 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8), as well as variants 2-7, encodes isoform 2.
    Source sequence(s)
    AL732563, AL805952
    UniProtKB/TrEMBL
    A0A6P5PPH9, Q3UH35
    Conserved Domains (1) summary
    cd16472
    Location:377 → 421
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins

  8. NM_001379579.1 → NP_001366508.1  E3 ubiquitin-protein ligase RNF38 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) represents the longest transcript and encodes the longest isoform (3).
    Source sequence(s)
    AL732563, AL805952
    Conserved Domains (1) summary
    cd16472
    Location:522 → 566
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins

  9. NM_001379580.1 → NP_001366509.1  E3 ubiquitin-protein ligase RNF38 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL732563, AL805952
    Conserved Domains (1) summary
    cd16472
    Location:518 → 562
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins

  10. NM_001379581.1 → NP_001366510.1  E3 ubiquitin-protein ligase RNF38 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL732563, AL805952
    Conserved Domains (1) summary
    cd16472
    Location:459 → 503
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins

  11. NM_175201.7 → NP_780410.2  E3 ubiquitin-protein ligase RNF38 isoform 1

    See identical proteins and their annotated locations for NP_780410.2

    Status: VALIDATED

    Source sequence(s)
    AL732563, AL805952
    Consensus CDS
    CCDS18122.1
    UniProtKB/Swiss-Prot
    Q6P5B1, Q8BI21
    UniProtKB/TrEMBL
    A0A6P5PPH5
    Related
    ENSMUSP00000095702.3, ENSMUST00000098098.9
    Conserved Domains (1) summary
    cd16472
    Location:409 → 453
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    44126210..44233929 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011250115.4 → XP_011248417.2  E3 ubiquitin-protein ligase RNF38 isoform X1

    Conserved Domains (1) summary
    cd16472
    Location:568 → 612
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins

  2. XM_011250117.4 → XP_011248419.2  E3 ubiquitin-protein ligase RNF38 isoform X4

    Conserved Domains (1) summary
    cd16472
    Location:534 → 578
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins

  3. XM_011250116.4 → XP_011248418.2  E3 ubiquitin-protein ligase RNF38 isoform X2

    Conserved Domains (1) summary
    cd16472
    Location:539 → 583
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins

  4. XM_036164489.1 → XP_036020382.1  E3 ubiquitin-protein ligase RNF38 isoform X7

    UniProtKB/TrEMBL
    A0A6P5PPH9, Q3UH35
    Conserved Domains (1) summary
    cd16472
    Location:377 → 421
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins

  5. XM_036164490.1 → XP_036020383.1  E3 ubiquitin-protein ligase RNF38 isoform X7

    UniProtKB/TrEMBL
    A0A6P5PPH9, Q3UH35
    Conserved Domains (1) summary
    cd16472
    Location:377 → 421
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins

  6. XM_030253834.2 → XP_030109694.1  E3 ubiquitin-protein ligase RNF38 isoform X3

    Conserved Domains (1) summary
    cd16472
    Location:538 → 582
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins

  7. XM_006538300.5 → XP_006538363.1  E3 ubiquitin-protein ligase RNF38 isoform X5

    Conserved Domains (1) summary
    cd16472
    Location:430 → 474
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins

  8. XM_036164491.1 → XP_036020384.1  E3 ubiquitin-protein ligase RNF38 isoform X7

    UniProtKB/TrEMBL
    A0A6P5PPH9, Q3UH35
    Conserved Domains (1) summary
    cd16472
    Location:377 → 421
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins

  9. XM_006538305.4 → XP_006538368.1  E3 ubiquitin-protein ligase RNF38 isoform X7

    See identical proteins and their annotated locations for XP_006538368.1

    UniProtKB/TrEMBL
    A0A6P5PPH9, Q3UH35
    Conserved Domains (1) summary
    cd16472
    Location:377 → 421
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins

  10. XM_006538301.4 → XP_006538364.1  E3 ubiquitin-protein ligase RNF38 isoform X6

    UniProtKB/TrEMBL
    A0A6P5PDQ3
    Conserved Domains (1) summary
    cd16472
    Location:425 → 469
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BI21.2 GenPept UniProtKB/Swiss-Prot:Q8BI21

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