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Rnf38 ring finger protein 38 [ Mus musculus (house mouse) ]

Gene ID: 73469, updated on 30-Apr-2024

Summary

Official Symbol
Rnf38provided by MGI
Official Full Name
ring finger protein 38provided by MGI
Primary source
MGI:MGI:1920719
See related
Ensembl:ENSMUSG00000035696 AllianceGenome:MGI:1920719
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Oip1; 1700065B19Rik; 2610202O07Rik
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. Predicted to be located in nucleoplasm and sperm flagellum. Is expressed in heart; limb; nervous system; and sensory organ. Orthologous to human RNF38 (ring finger protein 38). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 139.9), whole brain E14.5 (RPKM 39.1) and 24 other tissues See more
Orthologs
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Genomic context

See Rnf38 in Genome Data Viewer
Location:
4 B1; 4 23.13 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (44126210..44233929, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (44126210..44233905, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_10067 Neighboring gene STARR-positive B cell enhancer ABC_E7965 Neighboring gene glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase Neighboring gene prothymosin alpha, pseudogene 2 Neighboring gene STARR-positive B cell enhancer ABC_E10233 Neighboring gene STARR-positive B cell enhancer mm9_chr4:44186052-44186353 Neighboring gene STARR-positive B cell enhancer mm9_chr4:44212798-44213099 Neighboring gene microRNA 5106 Neighboring gene predicted gene, 54218 Neighboring gene STARR-seq mESC enhancer starr_10071 Neighboring gene STARR-seq mESC enhancer starr_10072 Neighboring gene STARR-positive B cell enhancer ABC_E6169 Neighboring gene maternal embryonic leucine zipper kinase Neighboring gene STARR-seq mESC enhancer starr_10073

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in sperm flagellum ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase RNF38
Names
RING-type E3 ubiquitin transferase RNF38
NP_001034082.1
NP_001342110.1
NP_001366503.1
NP_001366504.1
NP_001366505.1
NP_001366506.1
NP_001366507.1
NP_001366508.1
NP_001366509.1
NP_001366510.1
NP_780410.2
XP_006538363.1
XP_006538364.1
XP_006538368.1
XP_011248417.2
XP_011248418.2
XP_011248419.2
XP_030109694.1
XP_036020382.1
XP_036020383.1
XP_036020384.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001038993.5NP_001034082.1  E3 ubiquitin-protein ligase RNF38 isoform 2

    See identical proteins and their annotated locations for NP_001034082.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2), as well as variants 3-8, encodes isoform 2.
    Source sequence(s)
    AL732563, AL805952
    Consensus CDS
    CCDS18123.1
    UniProtKB/TrEMBL
    Q3UH35
    Related
    ENSMUSP00000038477.9, ENSMUST00000045793.15
    Conserved Domains (1) summary
    cd16472
    Location:377421
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins
  2. NM_001355181.2NP_001342110.1  E3 ubiquitin-protein ligase RNF38 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3), as well as variants 2 and 4-8, encodes isoform 2.
    Source sequence(s)
    AL732563, AL805952
    Consensus CDS
    CCDS18123.1
    UniProtKB/TrEMBL
    Q3UH35
    Conserved Domains (1) summary
    cd16472
    Location:377421
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins
  3. NM_001379574.1NP_001366503.1  E3 ubiquitin-protein ligase RNF38 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variants 2, 3, and 5-8, encodes isoform 2.
    Source sequence(s)
    AL732563, AL805952
    UniProtKB/TrEMBL
    Q3UH35
    Conserved Domains (1) summary
    cd16472
    Location:377421
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins
  4. NM_001379575.1NP_001366504.1  E3 ubiquitin-protein ligase RNF38 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variants 2-4 and 6-8, encodes isoform 2.
    Source sequence(s)
    AL732563, AL805952
    UniProtKB/TrEMBL
    Q3UH35
    Conserved Domains (1) summary
    cd16472
    Location:377421
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins
  5. NM_001379576.1NP_001366505.1  E3 ubiquitin-protein ligase RNF38 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variants 2-5, 7, and 8, encodes isoform 2.
    Source sequence(s)
    AL732563, AL805952
    UniProtKB/TrEMBL
    Q3UH35
    Conserved Domains (1) summary
    cd16472
    Location:377421
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins
  6. NM_001379577.1NP_001366506.1  E3 ubiquitin-protein ligase RNF38 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7), as well as variants 2-6 and 8, encodes isoform 2.
    Source sequence(s)
    AL732563, AL805952
    UniProtKB/TrEMBL
    Q3UH35
    Related
    ENSMUSP00000099998.3, ENSMUST00000102934.9
    Conserved Domains (1) summary
    cd16472
    Location:377421
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins
  7. NM_001379578.1NP_001366507.1  E3 ubiquitin-protein ligase RNF38 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8), as well as variants 2-7, encodes isoform 2.
    Source sequence(s)
    AL732563, AL805952
    UniProtKB/TrEMBL
    Q3UH35
    Conserved Domains (1) summary
    cd16472
    Location:377421
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins
  8. NM_001379579.1NP_001366508.1  E3 ubiquitin-protein ligase RNF38 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) represents the longest transcript and encodes the longest isoform (3).
    Source sequence(s)
    AL732563, AL805952
    Conserved Domains (1) summary
    cd16472
    Location:522566
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins
  9. NM_001379580.1NP_001366509.1  E3 ubiquitin-protein ligase RNF38 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL732563, AL805952
    Conserved Domains (1) summary
    cd16472
    Location:518562
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins
  10. NM_001379581.1NP_001366510.1  E3 ubiquitin-protein ligase RNF38 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL732563, AL805952
    Conserved Domains (1) summary
    cd16472
    Location:459503
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins
  11. NM_175201.7NP_780410.2  E3 ubiquitin-protein ligase RNF38 isoform 1

    See identical proteins and their annotated locations for NP_780410.2

    Status: VALIDATED

    Source sequence(s)
    AL732563, AL805952
    Consensus CDS
    CCDS18122.1
    UniProtKB/Swiss-Prot
    Q6P5B1, Q8BI21
    Related
    ENSMUSP00000095702.3, ENSMUST00000098098.9
    Conserved Domains (1) summary
    cd16472
    Location:409453
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    44126210..44233929 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011250115.4XP_011248417.2  E3 ubiquitin-protein ligase RNF38 isoform X1

    Conserved Domains (1) summary
    cd16472
    Location:568612
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins
  2. XM_011250117.4XP_011248419.2  E3 ubiquitin-protein ligase RNF38 isoform X4

    Conserved Domains (1) summary
    cd16472
    Location:534578
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins
  3. XM_011250116.4XP_011248418.2  E3 ubiquitin-protein ligase RNF38 isoform X2

    Conserved Domains (1) summary
    cd16472
    Location:539583
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins
  4. XM_036164489.1XP_036020382.1  E3 ubiquitin-protein ligase RNF38 isoform X7

    UniProtKB/TrEMBL
    Q3UH35
    Conserved Domains (1) summary
    cd16472
    Location:377421
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins
  5. XM_036164490.1XP_036020383.1  E3 ubiquitin-protein ligase RNF38 isoform X7

    UniProtKB/TrEMBL
    Q3UH35
    Conserved Domains (1) summary
    cd16472
    Location:377421
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins
  6. XM_030253834.2XP_030109694.1  E3 ubiquitin-protein ligase RNF38 isoform X3

    Conserved Domains (1) summary
    cd16472
    Location:538582
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins
  7. XM_006538300.5XP_006538363.1  E3 ubiquitin-protein ligase RNF38 isoform X5

    Conserved Domains (1) summary
    cd16472
    Location:430474
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins
  8. XM_036164491.1XP_036020384.1  E3 ubiquitin-protein ligase RNF38 isoform X7

    UniProtKB/TrEMBL
    Q3UH35
    Conserved Domains (1) summary
    cd16472
    Location:377421
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins
  9. XM_006538305.4XP_006538368.1  E3 ubiquitin-protein ligase RNF38 isoform X7

    See identical proteins and their annotated locations for XP_006538368.1

    UniProtKB/TrEMBL
    Q3UH35
    Conserved Domains (1) summary
    cd16472
    Location:377421
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins
  10. XM_006538301.4XP_006538364.1  E3 ubiquitin-protein ligase RNF38 isoform X6

    Conserved Domains (1) summary
    cd16472
    Location:425469
    RING-H2_RNF38_like; RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins