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rac1.L Rac family small GTPase 1 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 734382, updated on 5-Sep-2025
Official Symbol
rac1.L
Official Full Name
Rac family small GTPase 1 L homeolog
Primary source
Xenbase:XB-GENE-489012
Locus tag
XELAEV_18045321mg
See related
EnsemblRapid:ENSXLAG00005013098 AllianceGenome:Xenbase:XB-GENE-489012
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
rac; Xrac; mig5; rac1; tc-25; p21-rac1
Summary
Enables GTPase activity. Acts upstream of or within with a positive effect on actin filament polymerization and cellular component assembly involved in morphogenesis. Acts upstream of or within with a negative effect on neuron development. Acts upstream of or within several processes, including embryonic cranial skeleton morphogenesis; plasma membrane bounded cell projection assembly; and swimming behavior. Is expressed in ectoderm; musculoskeletal system; nervous system; and pharyngeal arch. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 48; colorectal cancer (multiple); lung cancer; and pancreatic adenocarcinoma. Orthologous to human RAC1 (Rac family small GTPase 1). [provided by Alliance of Genome Resources, Apr 2025]
Annotation information
Annotation category: partial on reference assembly
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See rac1.L in Genome Data Viewer
Location:
chromosome: 9_10L
Exon count:
6
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 9_10L NC_054387.1 (110922142..110940441, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 9_10L NC_030740.1 (100353220..100371546, complement)

Chromosome 9_10L - NC_054387.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108701588 Neighboring gene diacylglycerol lipase, beta L homeolog Neighboring gene family with sequence similarity 220 member A L homeolog Neighboring gene cytohesin 3 L homeolog

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. MgcRacGAP restricts active RhoA at the cytokinetic furrow and both RhoA and Rac1 at cell-cell junctions in epithelial cells. Breznau EB, et al. Mol Biol Cell, 2015 Jul 1. PMID 25947135, Free PMC Article
  2. Caveolin 1 is required for axonal outgrowth of motor neurons and affects Xenopus neuromuscular development. Breuer M, et al. Sci Rep, 2020 Oct 5. PMID 33020520, Free PMC Article
  3. The Rho guanine nucleotide exchange factor Trio is required for neural crest cell migration and interacts with Dishevelled. Kratzer MC, et al. Development, 2020 May 22. PMID 32366678
  4. The Rac1 regulator ELMO controls basal body migration and docking in multiciliated cells through interaction with Ezrin. Epting D, et al. Development, 2015 Jan 1. PMID 25516973
  5. Frizzled 3 acts upstream of Alcam during embryonic eye development. Seigfried FA, et al. Dev Biol, 2017 Jun 1. PMID 28427856

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Clone Names

  • MGC114731

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within_positive_effect actin filament polymerization IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within_positive_effect actin filament polymerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell migration IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cellular component assembly involved in morphogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within_positive_effect cellular component assembly involved in morphogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cellular component assembly involved in morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within_positive_effect cellular component assembly involved in morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within embryonic cranial skeleton morphogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within embryonic cranial skeleton morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within filopodium assembly IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within filopodium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lamellipodium assembly IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within lamellipodium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within_negative_effect neuron development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within swimming behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Preferred Names
Rac family small GTPase 1 L homeolog
Names
ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) L homeolog

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001095863.1 → NP_001089332.1  Rac family small GTPase 1 L homeolog

    See identical proteins and their annotated locations for NP_001089332.1

    Status: PROVISIONAL

    Source sequence(s)
    BC092101
    UniProtKB/TrEMBL
    A0A974D4N6, A0A974H459, Q58E25
    Related
    ENSXLAP00005038562.1, ENSXLAT00005039483.1
    Conserved Domains (2) summary
    smart00174
    Location:6 → 179
    RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
    cd01871
    Location:3 → 176
    Rac1_like; Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)-like consists of Rac1, Rac2 and Rac3

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054387.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    110922142..110940441 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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Molecular Biology Databases
Research Materials