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SUMO1 small ubiquitin like modifier 1 [ Homo sapiens (human) ]

Gene ID: 7341, updated on 2-Mar-2021

Summary

Official Symbol
SUMO1provided by HGNC
Official Full Name
small ubiquitin like modifier 1provided by HGNC
Primary source
HGNC:HGNC:12502
See related
Ensembl:ENSG00000116030 MIM:601912
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DAP1; GMP1; PIC1; SMT3; UBL1; OFC10; SENP2; SMT3C; SMT3H3
Summary
This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last four amino acids of the carboxy-terminus have been cleaved off. Several pseudogenes have been reported for this gene. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 51.9), adrenal (RPKM 51.8) and 25 other tissues See more
Orthologs
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Genomic context

See SUMO1 in Genome Data Viewer
Location:
2q33.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (202206171..202238597, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (203070894..203103320, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene KIAA2012 Neighboring gene proteasome subunit alpha 2 pseudogene 3 Neighboring gene DAZ associated protein 2 pseudogene 1 Neighboring gene short transmembrane mitochondrial protein 1 pseudogene Neighboring gene ribosomal protein L39 pseudogene 14 Neighboring gene NOP58 ribonucleoprotein Neighboring gene small nucleolar RNA, C/D box 70

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Disrupting the function of KIF4 leads Gag transient accumulation in discrete, perinuclear, nonendocytic clusters that co-localize with endogenous KIF4, Ubc9, and SUMO PubMed
integrase gag-pol SUMOylation of HIV-1 IN at positions K46, K136, and K244 by SUMO involves HIV-1 infectivity PubMed
gag-pol HIV-1 IN interacts with SUMO1/SUMO2 and Ubc9 in cells. Upregulations of SUMO1/SUMO2 and Ubc9 inhibit HIV-1 integration, while downregulations of SUMO1/SUMO2 and Ubc9 increase HIV-1 integration PubMed
p6 gag HIV-1 p6 interacts with SUMO-1 through a covalent attachment of SUMO-1 to lysine 27 of p6, resulting in the incorporation of SUMO-1 into HIV-1 virions PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
potassium channel regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tag IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
small protein activating enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription factor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin-like protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-specific protease binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA repair TAS
Traceable Author Statement
more info
PubMed 
cellular response to cadmium ion IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to heat IDA
Inferred from Direct Assay
more info
PubMed 
double-strand break repair via nonhomologous end joining TAS
Traceable Author Statement
more info
 
negative regulation of DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of action potential IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of delayed rectifier potassium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein-containing complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
protein stabilization IDA
Inferred from Direct Assay
more info
PubMed 
protein sumoylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein sumoylation IDA
Inferred from Direct Assay
more info
PubMed 
protein sumoylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein sumoylation TAS
Traceable Author Statement
more info
 
regulation of interferon-gamma-mediated signaling pathway TAS
Traceable Author Statement
more info
 
regulation of protein localization TAS
Traceable Author Statement
more info
PubMed 
roof of mouth development ISS
Inferred from Sequence or Structural Similarity
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
colocalizes_with PML body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
PML body IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with PML body IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nuclear body IDA
Inferred from Direct Assay
more info
PubMed 
nuclear envelope TAS
Traceable Author Statement
more info
 
nuclear membrane IDA
Inferred from Direct Assay
more info
 
nuclear pore TAS
Traceable Author Statement
more info
PubMed 
nuclear speck IEA
Inferred from Electronic Annotation
more info
 
nuclear stress granule IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus HDA PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with voltage-gated potassium channel complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
small ubiquitin-related modifier 1
Names
GAP modifying protein 1
SMT3 homolog 3
SMT3 suppressor of mif two 3 homolog 1
sentrin
ubiquitin-homology domain protein PIC1
ubiquitin-like protein SMT3C
ubiquitin-like protein UBL1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011679.1 RefSeqGene

    Range
    5003..37429
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001005781.2NP_001005781.1  small ubiquitin-related modifier 1 isoform a precursor

    See identical proteins and their annotated locations for NP_001005781.1

    Status: REVIEWED

    Source sequence(s)
    AC079354
    Consensus CDS
    CCDS2352.1
    UniProtKB/Swiss-Prot
    P63165
    UniProtKB/TrEMBL
    A0A024R3Z2
    Related
    ENSP00000376076.1, ENST00000392245.5
    Conserved Domains (1) summary
    cd16114
    Location:2196
    Ubl_SUMO1; ubiquitin-like (Ubl) domain found in small ubiquitin-related modifier 1 (SUMO-1) and similar proteins
  2. NM_001005782.2NP_001005782.1  small ubiquitin-related modifier 1 isoform b

    See identical proteins and their annotated locations for NP_001005782.1

    Status: REVIEWED

    Source sequence(s)
    AC079354
    Consensus CDS
    CCDS46493.1
    UniProtKB/Swiss-Prot
    P63165
    Related
    ENSP00000376075.3, ENST00000392244.7
    Conserved Domains (1) summary
    cd16114
    Location:471
    Ubl_SUMO1; ubiquitin-like (Ubl) domain found in small ubiquitin-related modifier 1 (SUMO-1) and similar proteins
  3. NM_001371392.1NP_001358321.1  small ubiquitin-related modifier 1 isoform d

    Status: REVIEWED

    Source sequence(s)
    AC079354
    Conserved Domains (1) summary
    cd16114
    Location:2095
    Ubl_SUMO1; ubiquitin-like (Ubl) domain found in small ubiquitin-related modifier 1 (SUMO-1) and similar proteins
  4. NM_001371393.1NP_001358322.1  small ubiquitin-related modifier 1 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC079354
    Related
    ENSP00000386296.1, ENST00000409712.5
    Conserved Domains (1) summary
    cl28922
    Location:2172
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
  5. NM_001371394.1NP_001358323.1  small ubiquitin-related modifier 1 isoform c

    Status: REVIEWED

    Source sequence(s)
    AC079354
    Related
    ENSP00000387204.1, ENST00000409368.5
    Conserved Domains (1) summary
    cd16114
    Location:21141
    Ubl_SUMO1; ubiquitin-like (Ubl) domain found in small ubiquitin-related modifier 1 (SUMO-1) and similar proteins
  6. NM_003352.8NP_003343.1  small ubiquitin-related modifier 1 isoform a precursor

    See identical proteins and their annotated locations for NP_003343.1

    Status: REVIEWED

    Source sequence(s)
    AC079354
    Consensus CDS
    CCDS2352.1
    UniProtKB/Swiss-Prot
    P63165
    UniProtKB/TrEMBL
    A0A024R3Z2
    Related
    ENSP00000376077.2, ENST00000392246.6
    Conserved Domains (1) summary
    cd16114
    Location:2196
    Ubl_SUMO1; ubiquitin-like (Ubl) domain found in small ubiquitin-related modifier 1 (SUMO-1) and similar proteins

RNA

  1. NR_163943.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC079354

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    202206171..202238597 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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