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OSGIN2 oxidative stress induced growth inhibitor family member 2 [ Homo sapiens (human) ]

Gene ID: 734, updated on 13-Mar-2020

Summary

Official Symbol
OSGIN2provided by HGNC
Official Full Name
oxidative stress induced growth inhibitor family member 2provided by HGNC
Primary source
HGNC:HGNC:1355
See related
Ensembl:ENSG00000164823 MIM:604598
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
hT41; C8orf1
Expression
Ubiquitous expression in fat (RPKM 10.6), brain (RPKM 9.0) and 25 other tissues See more
Orthologs

Genomic context

See OSGIN2 in Genome Data Viewer
Location:
8q21.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (89901868..89935614)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (90914096..90940096)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase subunit 6B1 pseudogene 6 Neighboring gene RNA, U6 small nuclear 925, pseudogene Neighboring gene nibrin Neighboring gene Sharpr-MPRA regulatory region 13813 Neighboring gene 2,4-dienoyl-CoA reductase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
growth factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell growth IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 

General protein information

Preferred Names
oxidative stress-induced growth inhibitor 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001126111.3NP_001119583.1  oxidative stress-induced growth inhibitor 2 isoform 1

    See identical proteins and their annotated locations for NP_001119583.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses an alternate 5'UTR that includes a translation start site that is upstream and in-frame with that used for variant 2. The resulting protein (isoform 1) is longer and has a distinct N-terminus compared to isoform 2.
    Source sequence(s)
    AF061326, BC031054, BM764021, BU739360
    Consensus CDS
    CCDS47888.1
    UniProtKB/Swiss-Prot
    Q9Y236
    Related
    ENSP00000396445.2, ENST00000451899.7
    Conserved Domains (1) summary
    cl21454
    Location:217363
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  2. NM_004337.2NP_004328.1  oxidative stress-induced growth inhibitor 2 isoform 2

    See identical proteins and their annotated locations for NP_004328.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5'UTR resulting in translation initiation from an internal AUG site compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1.
    Source sequence(s)
    AF061326, BC031054, BU688773
    Consensus CDS
    CCDS6248.1
    UniProtKB/Swiss-Prot
    Q9Y236
    UniProtKB/TrEMBL
    A0A024R9D5
    Related
    ENSP00000297438.2, ENST00000297438.6
    Conserved Domains (1) summary
    cl21454
    Location:173319
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    89901868..89935614
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011517287.3XP_011515589.1  oxidative stress-induced growth inhibitor 2 isoform X1

    See identical proteins and their annotated locations for XP_011515589.1

    UniProtKB/Swiss-Prot
    Q9Y236
    UniProtKB/TrEMBL
    A0A024R9D5
    Conserved Domains (1) summary
    cl21454
    Location:173319
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  2. XM_011517288.3XP_011515590.1  oxidative stress-induced growth inhibitor 2 isoform X2

    Conserved Domains (1) summary
    cl21454
    Location:40186
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
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