U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Hbp1 high mobility group box transcription factor 1 [ Mus musculus (house mouse) ]

Gene ID: 73389, updated on 9-May-2024

Summary

Official Symbol
Hbp1provided by MGI
Official Full Name
high mobility group box transcription factor 1provided by MGI
Primary source
MGI:MGI:894659
See related
Ensembl:ENSMUSG00000002996 AllianceGenome:MGI:894659
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700058O05Rik; C330012F01Rik
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of lipid transport and negative regulation of reactive oxygen species biosynthetic process. Predicted to be located in nuclear speck. Predicted to be active in nucleus. Is expressed in several structures, including brain; early conceptus; genitourinary system; gut; and neural retina. Orthologous to human HBP1 (HMG-box transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in mammary gland adult (RPKM 23.0), ovary adult (RPKM 22.7) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Hbp1 in Genome Data Viewer
Location:
12 A3; 12 13.73 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (31976449..32000529, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (31926452..31950530, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene component of oligomeric golgi complex 5 Neighboring gene predicted gene, 25913 Neighboring gene predicted gene, 35666 Neighboring gene STARR-positive B cell enhancer ABC_E79 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:32658358-32658559 Neighboring gene protein kinase, cAMP dependent regulatory, type II beta Neighboring gene predicted gene, 53716 Neighboring gene STARR-positive B cell enhancer ABC_E4024 Neighboring gene STARR-seq mESC enhancer starr_31869 Neighboring gene predicted gene, 51992

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (2) 
  • Targeted (3)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
HMG box-containing protein 1
Names
HMG box transcription factor 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001361928.1NP_001348857.1  HMG box-containing protein 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    CT010463
    UniProtKB/Swiss-Prot
    Q3V0I4, Q8BUS3, Q8C199, Q8R316
    UniProtKB/TrEMBL
    Q3UTR1
    Conserved Domains (2) summary
    smart00536
    Location:214340
    AXH; domain in Ataxins and HMG containing proteins
    cd01388
    Location:435506
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
  2. NM_153198.3NP_694878.2  HMG box-containing protein 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK132503, AK133127, CT010463
    Consensus CDS
    CCDS25867.2
    UniProtKB/TrEMBL
    E9Q1A8, Q3UTR1
    Related
    ENSMUSP00000131158.3, ENSMUST00000172314.9
    Conserved Domains (2) summary
    smart00536
    Location:224350
    AXH; domain in Ataxins and HMG containing proteins
    cd01388
    Location:445516
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
  3. NM_177993.4NP_818774.2  HMG box-containing protein 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and 3' coding region, compared to variant 1. It encodes isoform 2, which has a shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AK028674, AK133127
    Consensus CDS
    CCDS25868.2
    UniProtKB/TrEMBL
    E9Q469, Q3UQS1
    Related
    ENSMUSP00000131983.3, ENSMUST00000167458.9
    Conserved Domains (2) summary
    smart00536
    Location:224350
    AXH; domain in Ataxins and HMG containing proteins
    cl00082
    Location:445474
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    31976449..32000529 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157627.1XP_036013520.1  HMG box-containing protein 1 isoform X5

    UniProtKB/TrEMBL
    Q3UTR1
    Conserved Domains (2) summary
    cd01388
    Location:370441
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08517
    Location:190272
    AXH; Ataxin-1 and HBP1 module (AXH)
  2. XM_030246951.2XP_030102811.1  HMG box-containing protein 1 isoform X3

    UniProtKB/Swiss-Prot
    Q3V0I4, Q8BUS3, Q8C199, Q8R316
    UniProtKB/TrEMBL
    Q3UTR1
    Conserved Domains (2) summary
    smart00536
    Location:214340
    AXH; domain in Ataxins and HMG containing proteins
    cd01388
    Location:435506
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
  3. XM_036157626.1XP_036013519.1  HMG box-containing protein 1 isoform X4

    UniProtKB/TrEMBL
    Q3UTR1
    Conserved Domains (2) summary
    cd01388
    Location:370441
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam08517
    Location:190272
    AXH; Ataxin-1 and HBP1 module (AXH)
  4. XM_006515227.4XP_006515290.1  HMG box-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    Q3UTR1
    Conserved Domains (2) summary
    smart00536
    Location:224350
    AXH; domain in Ataxins and HMG containing proteins
    cd01388
    Location:445516
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
  5. XM_006515229.5XP_006515292.1  HMG box-containing protein 1 isoform X2

    See identical proteins and their annotated locations for XP_006515292.1

    UniProtKB/TrEMBL
    Q3UTR1
    Conserved Domains (2) summary
    smart00536
    Location:214340
    AXH; domain in Ataxins and HMG containing proteins
    cd01388
    Location:435506
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
  6. XM_006515228.5XP_006515291.1  HMG box-containing protein 1 isoform X2

    See identical proteins and their annotated locations for XP_006515291.1

    UniProtKB/TrEMBL
    Q3UTR1
    Conserved Domains (2) summary
    smart00536
    Location:214340
    AXH; domain in Ataxins and HMG containing proteins
    cd01388
    Location:435506
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...