CLDN4 claudin 4 [Sus scrofa (pig)] - Gene

Summary

Official Symbol: CLDN4provided by VGNC
Official Full Name: claudin 4provided by VGNC
Primary source: VGNC:VGNC:100383
See related: Ensembl:ENSSSCG00000007718
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression: Biased expression in liver (RPKM 66.5), subcutaneous adipose (RPKM 47.9) and 4 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 3

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	3	NC_010445.4 (11039711..11053930)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	3	NC_010445.3 (10776896..10788804, complement)

Chromosome 3 - NC_010445.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Highly abundant between enterocytes found on the intestinal villi and in crypts, with stable expression and localization following in vivo exposure to mycotoxin.
Title: Molecular and Physiological Effects on the Small Intestine of Weaner Pigs Following Feeding with Deoxynivalenol-Contaminated Feed.
Expression of Claudin-4 in Lung Ischemia-Reperfusion Injury in Experimental Lung Transplantation.
Title: Expression of Claudin-4 in Lung Ischemia-Reperfusion Injury in Experimental Lung Transplantation.
Tumor necrosis factor-alpha increases claudin-1, 4, and 7 expression in renal tubular cells, altering permeability and transepithelial electrical resistance.
Title: Tumor Necrosis Factor-α Increases Claudin-1, 4, and 7 Expression in Tubular Cells: Role in Permeability Changes.
Claudin-4 expression shows age-dependent change in cellular localization on pig jejunal villous epithelial cells
Title: Claudin-4 undergoes age-dependent change in cellular localization on pig jejunal villous epithelial cells, independent of bacterial colonization.
These findings indicate that claudin-4 and -7 may play a role in the gingiva junctional epithelium even in the absence of tight junctions.
Title: Expression of claudin-4 and -7 in porcine gingival junctional epithelium.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables structural molecule activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in bicellular tight junction assembly	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in bicellular tight junction	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: claudin-4

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.