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UBE2V1 ubiquitin conjugating enzyme E2 V1 [ Homo sapiens (human) ]

Gene ID: 7335, updated on 7-Jun-2020

Summary

Official Symbol
UBE2V1provided by HGNC
Official Full Name
ubiquitin conjugating enzyme E2 V1provided by HGNC
Primary source
HGNC:HGNC:12494
See related
Ensembl:ENSG00000244687 MIM:602995
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CIR1; UEV1; CROC1; UBE2V; UEV-1; UEV1A; CROC-1
Summary
Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene is located in the nucleus and can cause transcriptional activation of the human FOS proto-oncogene. It is thought to be involved in the control of differentiation by altering cell cycle behavior. Alternatively spliced transcript variants encoding multiple isoforms have been described for this gene, and multiple pseudogenes of this gene have been identified. Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (Kua-UEV), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Apr 2012]
Expression
Ubiquitous expression in brain (RPKM 23.0), placenta (RPKM 20.8) and 25 other tissues See more
Orthologs

Genomic context

See UBE2V1 in Genome Data Viewer
Location:
20q13.13
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (50081124..50115957, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (48697661..48732496, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene translation regulatory long non-coding RNA 1 Neighboring gene uncharacterized LOC105372655 Neighboring gene PEDS1-UBE2V1 readthrough Neighboring gene plasmanylethanolamine desaturase 1 Neighboring gene long intergenic non-protein coding RNA 1275

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat 47-59 peptide downregulates gene expression of ubiquitin-conjugating enzyme E2 variant 1 (UBE2V1) in U-937 macrophages PubMed
capsid gag Heterodimeric E2 UBC13-UEV1A and the arginine 63-linked ubiquitin chains play a role in TRIM5alpha-mediated signaling, which leads to capsid-specific restriction PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
UBC13-UEV1A complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus TAS
Traceable Author Statement
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin conjugating enzyme complex IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ubiquitin-conjugating enzyme E2 variant 1
Names
DNA-binding protein
TRAF6-regulated IKK activator 1 beta Uev1A

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029526.2 RefSeqGene

    Range
    5001..39834
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001032288.3NP_001027459.1  ubiquitin-conjugating enzyme E2 variant 1 isoform d

    See identical proteins and their annotated locations for NP_001027459.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (d) is shorter and has a distinct N-terminus, compared to isoform a.
    Source sequence(s)
    BC000468, BU934624, BX647511
    Consensus CDS
    CCDS33483.1
    UniProtKB/Swiss-Prot
    Q13404
    Related
    ENSP00000360739.3, ENST00000371674.7
    Conserved Domains (1) summary
    smart00212
    Location:16142
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
  2. NM_001257393.2NP_001244322.1  ubiquitin-conjugating enzyme E2 variant 1 isoform a

    See identical proteins and their annotated locations for NP_001244322.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 5 encode the same isoform (a)
    Source sequence(s)
    BX647511, CN346855, DA409547
    Consensus CDS
    CCDS13426.1
    UniProtKB/Swiss-Prot
    Q13404
    Conserved Domains (1) summary
    smart00212
    Location:39165
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
  3. NM_001257394.2NP_001244323.1  ubiquitin-conjugating enzyme E2 variant 1 isoform c

    See identical proteins and their annotated locations for NP_001244323.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an exon in the coding region and initiates translation at an alternate start codon, compared to variant 1. Variants 3 and 6 encode the same isoform (c), which is shorter and has a distinct N-terminus, compared to isoform a.
    Source sequence(s)
    BX647511, CD103154, DA409547
    Consensus CDS
    CCDS13427.1
    UniProtKB/Swiss-Prot
    Q13404
    Related
    ENSP00000407770.2, ENST00000415862.6
    Conserved Domains (1) summary
    cl00154
    Location:398
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
  4. NM_001257395.2NP_001244324.1  ubiquitin-conjugating enzyme E2 variant 1 isoform e

    See identical proteins and their annotated locations for NP_001244324.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR, initiates translation at an alternate start codon and uses an alternate splice site in the coding region, compared to variant 1. The encoded isoform (e) is shorter and has a distinct N-terminus, compared to isoform a.
    Source sequence(s)
    BU934624, BX647511, DA885410
    Conserved Domains (1) summary
    smart00212
    Location:13139
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
  5. NM_001257396.2NP_001244325.1  ubiquitin-conjugating enzyme E2 variant 1 isoform f

    See identical proteins and their annotated locations for NP_001244325.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR, initiates translation at an alternate start codon and lacks an exon in the 3' coding region, compared to variant 1. The encoded isoform (f) is shorter and has a distinct N-terminus, compared to isoform a.
    Source sequence(s)
    BU934624, BX647511, DA696213
    Consensus CDS
    CCDS58775.1
    UniProtKB/Swiss-Prot
    Q13404
    Related
    ENSP00000360720.5, ENST00000371657.9
    Conserved Domains (1) summary
    cl00154
    Location:16100
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
  6. NM_001257397.2NP_001244326.1  ubiquitin-conjugating enzyme E2 variant 1 isoform g

    See identical proteins and their annotated locations for NP_001244326.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR, contains an alternate internal exon and initiates translation at a downstream, in-frame start codon, compared to variant 1. Variants 9, 10, 11, 14, and 17 encode the same isoform (g), which has a shorter N-terminus compared to isoform a.
    Source sequence(s)
    BU934624, BX647511, DB448941
    Consensus CDS
    CCDS74740.1
    UniProtKB/TrEMBL
    G3V2F7
    Conserved Domains (1) summary
    smart00212
    Location:2100
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
  7. NM_001257398.1NP_001244327.1  ubiquitin-conjugating enzyme E2 variant 1 isoform g

    See identical proteins and their annotated locations for NP_001244327.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR, contains an alternate internal exon and initiates translation at a downstream, in-frame start codon, compared to variant 1. Variants 9, 10, 11, 14, and 17 encode the same isoform (g), which has a shorter N-terminus compared to isoform a.
    Source sequence(s)
    BU934624, BX647511, DA519011, DA892136
    Consensus CDS
    CCDS74740.1
    UniProtKB/TrEMBL
    G3V2F7
    Related
    ENSP00000485599.1, ENST00000625172.3
    Conserved Domains (1) summary
    smart00212
    Location:2100
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
  8. NM_001257399.2NP_001244328.1  ubiquitin-conjugating enzyme E2 variant 1 isoform g

    See identical proteins and their annotated locations for NP_001244328.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR, contains an alternate internal exon and initiates translation at a downstream, in-frame start codon, compared to variant 1. Variants 9, 10, 11, 14, and 17 encode the same isoform (g), which has a shorter N-terminus compared to isoform a.
    Source sequence(s)
    BU934624, BX647511, DA573591, DA625165
    Consensus CDS
    CCDS74740.1
    UniProtKB/TrEMBL
    G3V2F7
    Conserved Domains (1) summary
    smart00212
    Location:2100
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
  9. NM_001282575.3NP_001269504.1  ubiquitin-conjugating enzyme E2 variant 1 isoform h

    See identical proteins and their annotated locations for NP_001269504.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) uses an alternate 5' exon structure, and thus differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at an alternate AUG and result in an isoform (h) with a shorter and distinct N-terminus, compared to isoform a. Variants 12, 15, and 16 encode the same isoform (h).
    Source sequence(s)
    BC005215, BX647511, KF456937
    Conserved Domains (1) summary
    cl00154
    Location:286
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
  10. NM_001282576.1NP_001269505.1  ubiquitin-conjugating enzyme E2 variant 1 isoform g

    See identical proteins and their annotated locations for NP_001269505.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14) differs in the 5' UTR, contains an alternate internal exon and initiates translation at a downstream, in-frame start codon, compared to variant 1. Variants 9, 10, 11, 14, and 17 encode the same isoform (g), which has a shorter N-terminus compared to isoform a.
    Source sequence(s)
    BU934624, BX647511, DA519011, DA642098
    Consensus CDS
    CCDS74740.1
    UniProtKB/TrEMBL
    G3V2F7
    Related
    ENSP00000484828.1, ENST00000617119.4
    Conserved Domains (1) summary
    smart00212
    Location:2100
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
  11. NM_001282577.3NP_001269506.1  ubiquitin-conjugating enzyme E2 variant 1 isoform h

    See identical proteins and their annotated locations for NP_001269506.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15) uses an alternate 5' exon structure, and thus differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at an alternate AUG and result in an isoform (h) with a shorter and distinct N-terminus, compared to isoform a. Variants 12, 15, and 16 encode the same isoform (h).
    Source sequence(s)
    BU934624, BX647511, DA087027, KF456937
    Conserved Domains (1) summary
    cl00154
    Location:286
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
  12. NM_001282578.3NP_001269507.1  ubiquitin-conjugating enzyme E2 variant 1 isoform h

    See identical proteins and their annotated locations for NP_001269507.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16) uses an alternate 5' exon structure, and thus differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at an alternate AUG and result in an isoform (h) with a shorter and distinct N-terminus, compared to isoform a. Variants 12, 15, and 16 encode the same isoform (h).
    Source sequence(s)
    BU934624, BX647511, DA916492, KF456937
    Conserved Domains (1) summary
    cl00154
    Location:286
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
  13. NM_001282579.1NP_001269508.1  ubiquitin-conjugating enzyme E2 variant 1 isoform g

    See identical proteins and their annotated locations for NP_001269508.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17) differs in the 5' UTR, contains an alternate internal exon and initiates translation at a downstream, in-frame start codon, compared to variant 1. Variants 9, 10, 11, 14, and 17 encode the same isoform (g), which has a shorter N-terminus compared to isoform a.
    Source sequence(s)
    BU934624, BX647511, DA519011, HY019085
    Consensus CDS
    CCDS74740.1
    UniProtKB/TrEMBL
    G3V2F7
    Related
    ENSP00000450635.2, ENST00000557021.5
    Conserved Domains (1) summary
    smart00212
    Location:2100
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
  14. NM_001282580.1NP_001269509.1  ubiquitin-conjugating enzyme E2 variant 1 isoform i

    See identical proteins and their annotated locations for NP_001269509.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18) has multiple differences in the coding region, compared to variant 1. The resulting protein (isoform i) has a distinct N- and C-termini and is shorter than isoform 1.
    Source sequence(s)
    AI688615, BF446402, BF690501, BU934624, CF127653, DA519011
    Conserved Domains (1) summary
    cl00154
    Location:1656
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
  15. NM_021988.6NP_068823.2  ubiquitin-conjugating enzyme E2 variant 1 isoform a

    See identical proteins and their annotated locations for NP_068823.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1, 2 and 5 encode the same isoform.
    Source sequence(s)
    AK314754, BX647511, DA409547
    Consensus CDS
    CCDS13426.1
    UniProtKB/Swiss-Prot
    Q13404
    Related
    ENSP00000340305.3, ENST00000340309.7
    Conserved Domains (1) summary
    smart00212
    Location:39165
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
  16. NM_022442.6NP_071887.1  ubiquitin-conjugating enzyme E2 variant 1 isoform c

    See identical proteins and their annotated locations for NP_071887.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, initiates translation at an alternate start codon and lacks an exon in the coding region, compared to variant 1. Variants 3 and 6 encode the same isoform (c), which is shorter and has a distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AL034423
    Consensus CDS
    CCDS13427.1
    UniProtKB/Swiss-Prot
    Q13404
    Conserved Domains (1) summary
    cl00154
    Location:398
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
  17. NM_199144.3NP_954595.1  ubiquitin-conjugating enzyme E2 variant 1 isoform a

    See identical proteins and their annotated locations for NP_954595.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 5 encode the same isoform (a).
    Source sequence(s)
    BU540046, BX647511
    Consensus CDS
    CCDS13426.1
    UniProtKB/Swiss-Prot
    Q13404
    Related
    ENSP00000360742.3, ENST00000371677.7
    Conserved Domains (1) summary
    smart00212
    Location:39165
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

RNA

  1. NR_047554.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13) uses an alternate 5'-most exon and lacks an internal exon, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region found in variant 4.
    Source sequence(s)
    BU934624, BX647511
    Related
    ENST00000396059.7
  2. NR_104218.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (19) uses an alternate 5' and 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AI688615, BF446402, BF690501, BU934624, BX375182, DA519011

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    50081124..50115957 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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