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Nptxr neuronal pentraxin receptor [ Mus musculus (house mouse) ]

Gene ID: 73340, updated on 9-May-2024

Summary

Official Symbol
Nptxrprovided by MGI
Official Full Name
neuronal pentraxin receptorprovided by MGI
Primary source
MGI:MGI:1920590
See related
Ensembl:ENSMUSG00000022421 AllianceGenome:MGI:1920590
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NPR; Npcd; D15Bwg0580e; 1200009K17Rik; 1700036C17Rik; 5730406O18Rik
Summary
This gene encodes a protein similar to the rat neuronal pentraxin receptor. The rat pentraxin receptor is an integral membrane protein that is thought to mediate neuronal uptake of the snake venom toxin, taipoxin, and its transport into the synapses. Studies in rat indicate that translation of this mRNA initiates at a non-AUG (CUG) codon. This may also be true for mouse and human, based on strong sequence conservation amongst these species. [provided by RefSeq, Jul 2008]
Expression
Biased expression in frontal lobe adult (RPKM 79.6), cortex adult (RPKM 75.7) and 5 other tissues See more
Orthologs
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Genomic context

See Nptxr in Genome Data Viewer
Location:
15 E1; 15 37.85 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (79670552..79688910, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (79786351..79804709, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene dynein, axonemal, light chain 4 Neighboring gene STARR-positive B cell enhancer ABC_E390 Neighboring gene predicted gene, 30977 Neighboring gene predicted gene, 57816 Neighboring gene neuronal pentraxin chromo domain Neighboring gene chromobox 6 Neighboring gene predicted gene 10856

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough Npcd

Readthrough gene: Npcd, Included gene: Cbx6

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables pentraxin receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
neuronal pentraxin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030689.4NP_109614.2  neuronal pentraxin receptor precursor

    Status: REVIEWED

    Source sequence(s)
    AC118227, BC058962
    Consensus CDS
    CCDS27653.1
    UniProtKB/Swiss-Prot
    Q99J85
    UniProtKB/TrEMBL
    A0A9R1SP20, B9EIV5
    Related
    ENSMUSP00000023057.10, ENSMUST00000023057.10
    Conserved Domains (1) summary
    smart00159
    Location:281487
    PTX; Pentraxin / C-reactive protein / pentaxin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    79670552..79688910 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)