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UBE2N ubiquitin conjugating enzyme E2 N [ Homo sapiens (human) ]

Gene ID: 7334, updated on 5-Jan-2020

Summary

Official Symbol
UBE2Nprovided by HGNC
Official Full Name
ubiquitin conjugating enzyme E2 Nprovided by HGNC
Primary source
HGNC:HGNC:12492
See related
Ensembl:ENSG00000177889 MIM:603679
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UBC13; UbcH13; HEL-S-71; UbcH-ben; UBCHBEN; UBC13
Summary
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Studies in mouse suggest that this protein plays a role in DNA postreplication repair. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 18.8), brain (RPKM 12.2) and 25 other tissues See more
Orthologs

Genomic context

See UBE2N in Genome Data Viewer
Location:
12q22
Exon count:
4
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (93405684..93442336, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (93802088..93836026, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC643339 Neighboring gene HNF4 motif-containing MPRA enhancer 125 Neighboring gene uncharacterized LOC105369909 Neighboring gene uncharacterized LOC112267866 Neighboring gene nudix hydrolase 4 Neighboring gene mitochondrial ribosomal protein L42 Neighboring gene RNA, 7SL, cytoplasmic 737, pseudogene Neighboring gene SOCS2 antisense RNA 1 Neighboring gene suppressor of cytokine signaling 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
capsid gag Heterodimeric E2 UBC13-UEV1A and the arginine 63-linked ubiquitin chains play a role in TRIM5alpha-mediated signaling, which leads to capsid-specific restriction PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC8489, MGC131857

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin binding IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin conjugating enzyme activity ISS
Inferred from Sequence or Structural Similarity
more info
 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
DNA double-strand break processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
JNK cascade TAS
Traceable Author Statement
more info
 
T cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
activation of MAPK activity TAS
Traceable Author Statement
more info
 
cellular protein modification process TAS
Traceable Author Statement
more info
PubMed 
double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
double-strand break repair via nonhomologous end joining TAS
Traceable Author Statement
more info
 
histone ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
interleukin-1-mediated signaling pathway TAS
Traceable Author Statement
more info
 
nucleotide-binding oligomerization domain containing signaling pathway TAS
Traceable Author Statement
more info
 
positive regulation of DNA repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of NF-kappaB transcription factor activity TAS
Traceable Author Statement
more info
 
positive regulation of histone modification IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of ubiquitin-protein transferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
postreplication repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
postreplication repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein K63-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein K63-linked ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein K63-linked ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein ubiquitination TAS
Traceable Author Statement
more info
PubMed 
proteolysis TAS
Traceable Author Statement
more info
PubMed 
regulation of DNA repair TAS
Traceable Author Statement
more info
PubMed 
regulation of histone ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
UBC13-MMS2 complex IDA
Inferred from Direct Assay
more info
PubMed 
UBC13-UEV1A complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
fibrillar center IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ubiquitin-conjugating enzyme E2 N
Names
E2 ubiquitin-conjugating enzyme N
bendless-like ubiquitin conjugating enzyme
epididymis secretory protein Li 71
ubiquitin carrier protein N
ubiquitin conjugating enzyme E2N
ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)
ubiquitin-conjugating enzyme E2N (homologous to yeast UBC13)
ubiquitin-protein ligase N
yeast UBC13 homolog
NP_003339.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003348.4NP_003339.1  ubiquitin-conjugating enzyme E2 N

    See identical proteins and their annotated locations for NP_003339.1

    Status: REVIEWED

    Source sequence(s)
    AC025260, AK098233, BC000396, CB243041
    Consensus CDS
    CCDS31875.1
    UniProtKB/Swiss-Prot
    P61088
    UniProtKB/TrEMBL
    V9HW41
    Related
    ENSP00000316176.2, ENST00000318066.7
    Conserved Domains (1) summary
    cl00154
    Location:4151
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    93405684..93442336 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_002957379.1 RNA Sequence

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