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Calr3 calreticulin 3 [ Mus musculus (house mouse) ]

Gene ID: 73316, updated on 11-Apr-2024

Summary

Official Symbol
Calr3provided by MGI
Official Full Name
calreticulin 3provided by MGI
Primary source
MGI:MGI:1920566
See related
Ensembl:ENSMUSG00000019732 AllianceGenome:MGI:1920566
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Crt2; cspn; 1700031L01Rik; 6330586I20Rik
Summary
Enables protein folding chaperone. Predicted to be involved in protein folding and ubiquitin-dependent ERAD pathway. Predicted to act upstream of or within cell differentiation and spermatogenesis. Predicted to be located in endoplasmic reticulum lumen and nuclear envelope. Predicted to be active in endoplasmic reticulum membrane. Is expressed in cerebral cortex and telencephalon. Orthologous to human CALR3 (calreticulin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 18.6) and heart adult (RPKM 2.7) See more
Orthologs
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Genomic context

See Calr3 in Genome Data Viewer
Location:
8 B3.3; 8 35.08 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (73178020..73197638, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (72424176..72443819, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3785 Neighboring gene STARR-seq mESC enhancer starr_21854 Neighboring gene STARR-seq mESC enhancer starr_21858 Neighboring gene Kruppel-like transcription factor 2 (lung) Neighboring gene STARR-positive B cell enhancer ABC_E8247 Neighboring gene epidermal growth factor receptor pathway substrate 15-like 1 Neighboring gene STARR-positive B cell enhancer ABC_E9731 Neighboring gene STARR-positive B cell enhancer ABC_E5020 Neighboring gene predicted gene, 46043 Neighboring gene RIKEN cDNA 1700030K09 gene Neighboring gene STARR-positive B cell enhancer ABC_E359 Neighboring gene calcium homeostasis endoplasmic reticulum protein Neighboring gene microRNA 7068

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein folding chaperone IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum lumen ISO
Inferred from Sequence Orthology
more info
 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
calreticulin-3
Names
calreticulin-2
calspeculin
calsperin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028500.3NP_082776.2  calreticulin-3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_082776.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK006582, AK046081
    Consensus CDS
    CCDS22413.1
    UniProtKB/Swiss-Prot
    G5E827, Q9D9Q6
    UniProtKB/TrEMBL
    B1Q2L7
    Related
    ENSMUSP00000019876.6, ENSMUST00000019876.12
    Conserved Domains (1) summary
    pfam00262
    Location:23315
    Calreticulin; Calreticulin family
  2. NM_029782.3NP_084058.2  calreticulin-3 isoform 2

    See identical proteins and their annotated locations for NP_084058.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains a distinct 5' UTR and 5' coding region, compared to variant 1. These differences result in a protein (isoform 2) with a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK046081
    Consensus CDS
    CCDS40388.1
    UniProtKB/TrEMBL
    Q8BL82
    Related
    ENSMUSP00000105601.2, ENSMUST00000109974.2
    Conserved Domains (1) summary
    pfam00262
    Location:25207
    Calreticulin; Calreticulin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    73178020..73197638 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509761.5XP_006509824.1  calreticulin-3 isoform X1

    UniProtKB/TrEMBL
    B1Q2L7
    Conserved Domains (1) summary
    pfam00262
    Location:23257
    Calreticulin; Calreticulin family
  2. XM_030243800.1XP_030099660.1  calreticulin-3 isoform X2

    Conserved Domains (1) summary
    pfam00262
    Location:25149
    Calreticulin; Calreticulin family