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UBE2E2 ubiquitin conjugating enzyme E2 E2 [ Homo sapiens (human) ]

Gene ID: 7325, updated on 6-Jan-2019

Summary

Official Symbol
UBE2E2provided by HGNC
Official Full Name
ubiquitin conjugating enzyme E2 E2provided by HGNC
Primary source
HGNC:HGNC:12478
See related
Ensembl:ENSG00000182247 MIM:602163
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UBCH8
Expression
Ubiquitous expression in brain (RPKM 1.5), fat (RPKM 1.2) and 25 other tissues See more
Orthologs

Genomic context

See UBE2E2 in Genome Data Viewer
Location:
3p24.3
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (23203007..23590805)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (23244498..23632296)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L24 pseudogene 7 Neighboring gene UBE2E2 antisense RNA 1 (head to head) Neighboring gene uncharacterized LOC105376991 Neighboring gene uncharacterized LOC107986069 Neighboring gene RNA, U6 small nuclear 922, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies three novel loci for type 2 diabetes.
NHGRI GWA Catalog
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
NHGRI GWA Catalog
Genome-wide association study of atypical psychosis.
NHGRI GWA Catalog
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
NHGRI GWA Catalog

Pathways from BioSystems

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
    Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
  • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
    Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
    Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
  • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
    Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
  • protein ubiquitylation, organism-specific biosystem (from BIOCYC)
    protein ubiquitylation, organism-specific biosystem
    protein ubiquitylation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ25157

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ISG15 transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ISG15 transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin conjugating enzyme activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
ISG15-protein conjugation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ISG15-protein conjugation IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to DNA damage stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of G1/S transition of mitotic cell cycle IGI
Inferred from Genetic Interaction
more info
PubMed 
protein K11-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein K11-linked ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein K48-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein K48-linked ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein K63-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein K63-linked ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ubiquitin-conjugating enzyme E2 E2
Names
E2 ubiquitin-conjugating enzyme E2
ubiquitin carrier protein E2
ubiquitin conjugating enzyme E2E 2
ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homolog, yeast)
ubiquitin-conjugating enzyme E2E 2 (homologous to yeast UBC4/5)
ubiquitin-protein ligase E2
NP_689866.1
XP_005265489.1
XP_005265490.1
XP_011532377.1
XP_011532378.1
XP_016862615.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152653.4NP_689866.1  ubiquitin-conjugating enzyme E2 E2

    See identical proteins and their annotated locations for NP_689866.1

    Status: VALIDATED

    Source sequence(s)
    AC116992, AK057886, BC022332, CB851345
    Consensus CDS
    CCDS2637.1
    UniProtKB/Swiss-Prot
    Q96LR5
    UniProtKB/TrEMBL
    A0A024R2Q2
    Related
    ENSP00000379931.1, ENST00000396703.5
    Conserved Domains (1) summary
    pfam00179
    Location:59196
    UQ_con; Ubiquitin-conjugating enzyme

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

    Range
    23203007..23590805
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534076.3XP_011532378.1  ubiquitin-conjugating enzyme E2 E2 isoform X5

  2. XM_017007126.1XP_016862615.1  ubiquitin-conjugating enzyme E2 E2 isoform X3

  3. XM_011534075.1XP_011532377.1  ubiquitin-conjugating enzyme E2 E2 isoform X4

  4. XM_005265432.3XP_005265489.1  ubiquitin-conjugating enzyme E2 E2 isoform X1

    See identical proteins and their annotated locations for XP_005265489.1

    UniProtKB/Swiss-Prot
    Q96LR5
    UniProtKB/TrEMBL
    A0A024R2Q2
    Related
    ENSP00000401053.1, ENST00000425792.5
    Conserved Domains (1) summary
    pfam00179
    Location:59196
    UQ_con; Ubiquitin-conjugating enzyme
  5. XM_005265433.5XP_005265490.1  ubiquitin-conjugating enzyme E2 E2 isoform X2

    Conserved Domains (1) summary
    pfam00179
    Location:59171
    UQ_con; Ubiquitin-conjugating enzyme

RNA

  1. XR_001740249.2 RNA Sequence

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