Format

Send to:

Choose Destination

UBE2B ubiquitin conjugating enzyme E2 B [ Homo sapiens (human) ]

Gene ID: 7320, updated on 24-Nov-2020

Summary

Official Symbol
UBE2Bprovided by HGNC
Official Full Name
ubiquitin conjugating enzyme E2 Bprovided by HGNC
Primary source
HGNC:HGNC:12473
See related
Ensembl:ENSG00000119048 MIM:179095
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HR6B; UBC2; HHR6B; RAD6B; E2-17kDa
Summary
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in adrenal (RPKM 31.0), heart (RPKM 26.8) and 25 other tissues See more
Orthologs

Genomic context

See UBE2B in Genome Data Viewer
Location:
5q31.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (134371569..134392108)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (133706843..133727799)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene protein phosphatase 2 catalytic subunit alpha Neighboring gene microRNA 3661 Neighboring gene cyclin dependent kinase like 3 Neighboring gene ribosomal protein S13 pseudogene 6 Neighboring gene CDKN2A interacting protein N-terminal like Neighboring gene ribosomal protein S10 pseudogene 11

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of ubiquitin-conjugating enzyme E2B (UBE2B) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-protein transferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
DNA damage response, detection of DNA damage TAS
Traceable Author Statement
more info
 
DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA repair IGI
Inferred from Genetic Interaction
more info
PubMed 
cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
PubMed 
chiasma assembly IEA
Inferred from Electronic Annotation
more info
 
heterochromatin maintenance IEA
Inferred from Electronic Annotation
more info
 
histone H2A ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
histone lysine demethylation IEA
Inferred from Electronic Annotation
more info
 
histone ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
meiotic telomere clustering IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cAMP-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of histone phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of canonical Wnt signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of reciprocal meiotic recombination IEA
Inferred from Electronic Annotation
more info
 
postreplication repair IDA
Inferred from Direct Assay
more info
PubMed 
postreplication repair NAS
Non-traceable Author Statement
more info
PubMed 
proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteasome-mediated ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
protein K11-linked ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein K48-linked ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein K63-linked ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein autoubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein monoubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein polyubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein stabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein ubiquitination TAS
Traceable Author Statement
more info
 
response to UV IGI
Inferred from Genetic Interaction
more info
PubMed 
response to drug IDA
Inferred from Direct Assay
more info
PubMed 
sperm axoneme assembly IEA
Inferred from Electronic Annotation
more info
 
spermatogenesis TAS
Traceable Author Statement
more info
PubMed 
synaptonemal complex organization IEA
Inferred from Electronic Annotation
more info
 
ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-dependent protein catabolic process NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
HULC complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
HULC complex IDA
Inferred from Direct Assay
more info
PubMed 
XY body IEA
Inferred from Electronic Annotation
more info
 
chromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromatin ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
replication fork IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ubiquitin-conjugating enzyme E2 B
Names
E2 protein
E2 ubiquitin-conjugating enzyme B
RAD6 homolog B
ubiquitin carrier protein B
ubiquitin conjugating enzyme E2B
ubiquitin-conjugating enzyme E2-17 kDa
ubiquitin-conjugating enzyme E2B (RAD6 homolog)
ubiquitin-protein ligase B
NP_003328.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046936.1 RefSeqGene

    Range
    5394..25933
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003337.4NP_003328.1  ubiquitin-conjugating enzyme E2 B

    See identical proteins and their annotated locations for NP_003328.1

    Status: REVIEWED

    Source sequence(s)
    AK312012, BU954901, M74525, T88933
    Consensus CDS
    CCDS4174.1
    UniProtKB/Swiss-Prot
    P63146
    Related
    ENSP00000265339.2, ENST00000265339.7
    Conserved Domains (1) summary
    pfam00179
    Location:8145
    UQ_con; Ubiquitin-conjugating enzyme

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    134371569..134392108
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center