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Xpot exportin, tRNA (nuclear export receptor for tRNAs) [ Mus musculus (house mouse) ]

Gene ID: 73192, updated on 26-Sep-2022

Summary

Official Symbol
Xpotprovided by MGI
Official Full Name
exportin, tRNA (nuclear export receptor for tRNAs)provided by MGI
Primary source
MGI:MGI:1920442
See related
Ensembl:ENSMUSG00000034667 AllianceGenome:MGI:1920442
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EXPORTIN-T; 1110004L07Rik; 3110065H13Rik
Summary
Predicted to enable tRNA binding activity. Predicted to be involved in tRNA re-export from nucleus. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of nuclear pore. Predicted to be active in cytoplasm and nuclear matrix. Is expressed in endocrine gland; female reproductive system; mammary gland; peripheral nervous system; and trigeminal nerve. Orthologous to human XPOT (exportin for tRNA). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 13.2), liver E14 (RPKM 10.9) and 28 other tissues See more
Orthologs
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Genomic context

See Xpot in Genome Data Viewer
Location:
10; 10 D2
Exon count:
26
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (121423285..121462413, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (121587380..121626506, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35696 Neighboring gene TANK-binding kinase 1 Neighboring gene predicted gene, 35816 Neighboring gene RIKEN cDNA D930020B18 gene Neighboring gene predicted gene, 35865

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
 
enables tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables tRNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in tRNA export from nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in tRNA re-export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in nuclear matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of nuclear pore ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
exportin-T
Names
exportin(tRNA)
tRNA exportin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081056.3NP_001074525.1  exportin-T isoform 1

    See identical proteins and their annotated locations for NP_001074525.1

    Status: VALIDATED

    Source sequence(s)
    AC124413, AC124992
    Consensus CDS
    CCDS88093.1
    UniProtKB/TrEMBL
    A0A1W2P7Q6
    Related
    ENSMUSP00000151722.2, ENSMUST00000218004.2
    Conserved Domains (2) summary
    smart00913
    Location:2188
    IBN_N; Importin-beta N-terminal domain
    pfam08389
    Location:100247
    Xpo1; Exportin 1-like protein
  2. NM_001359618.2NP_001346547.1  exportin-T isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124413, AC124992
    Consensus CDS
    CCDS88093.1
    UniProtKB/TrEMBL
    A0A1W2P7Q6
    Conserved Domains (2) summary
    smart00913
    Location:2188
    IBN_N; Importin-beta N-terminal domain
    pfam08389
    Location:100247
    Xpo1; Exportin 1-like protein
  3. NM_001401044.1NP_001387973.1  exportin-T isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC124413, AC124992
  4. NM_001401045.1NP_001387974.1  exportin-T isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC124413, AC124992

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    121423285..121462413 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245307.2XP_030101167.1  exportin-T isoform X2

    Conserved Domains (2) summary
    smart00913
    Location:2188
    IBN_N; Importin-beta N-terminal domain
    pfam08389
    Location:100247
    Xpo1; Exportin 1-like protein
  2. XM_030245308.1XP_030101168.1  exportin-T isoform X3

    Conserved Domains (1) summary
    pfam08389
    Location:6137
    Xpo1; Exportin 1-like protein
  3. XM_006514208.5XP_006514271.1  exportin-T isoform X3

    Conserved Domains (1) summary
    pfam08389
    Location:6137
    Xpo1; Exportin 1-like protein
  4. XM_030245306.2XP_030101166.1  exportin-T isoform X1

    Conserved Domains (2) summary
    smart00913
    Location:2188
    IBN_N; Importin-beta N-terminal domain
    pfam08389
    Location:98245
    Xpo1; Exportin 1-like protein
  5. XM_006514206.4XP_006514269.1  exportin-T isoform X1

    Conserved Domains (2) summary
    smart00913
    Location:2188
    IBN_N; Importin-beta N-terminal domain
    pfam08389
    Location:98245
    Xpo1; Exportin 1-like protein
  6. XM_006514207.5XP_006514270.1  exportin-T isoform X2

    Conserved Domains (2) summary
    smart00913
    Location:2188
    IBN_N; Importin-beta N-terminal domain
    pfam08389
    Location:100247
    Xpo1; Exportin 1-like protein