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UBA1 ubiquitin like modifier activating enzyme 1 [ Homo sapiens (human) ]

Gene ID: 7317, updated on 1-Jun-2020

Summary

Official Symbol
UBA1provided by HGNC
Official Full Name
ubiquitin like modifier activating enzyme 1provided by HGNC
Primary source
HGNC:HGNC:12469
See related
Ensembl:ENSG00000130985 MIM:314370
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
A1S9; A1ST; GXP1; UBE1; A1S9T; AMCX1; POC20; SMAX2; UBA1A; UBE1X; CFAP124
Summary
The protein encoded by this gene catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. This gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cluster on chromosome Xp11.23. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 27.6), brain (RPKM 26.8) and 25 other tissues See more
Orthologs

Genomic context

See UBA1 in Genome Data Viewer
Location:
Xp11.3
Exon count:
31
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (47190847..47215128)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (47050199..47074527)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase subunit B11 Neighboring gene RNA binding motif protein 10 Neighboring gene ITPK1 pseudogene 1 Neighboring gene uncharacterized LOC105373194 Neighboring gene inactivation escape 1 Neighboring gene cyclin dependent kinase 16 Neighboring gene ubiquitin specific peptidase 11

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Ubiquitination of HIV-1 Tat by Hdm2 requires ubiquitin-activating enzyme E1 PubMed
Vif vif HIV-1 is dependent on UBA1 (lysine at position 48, UbK48) for A3G degradation; results suggest that UbK48 is the primary ubiquitin conjugate needed for A3G degradation PubMed
integrase gag-pol HIV-1 IN is identified to have a physical interaction with ubiquitin-like modifier activating enzyme 1 (UBA1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC4781

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin activating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin activating enzyme activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin activating enzyme activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
cellular response to DNA damage stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
PubMed 
protein modification by small protein conjugation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
protein ubiquitination TAS
Traceable Author Statement
more info
 
ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
colocalizes_with desmosome IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
colocalizes_with heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with lysosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus HDA PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with rough endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ubiquitin-like modifier-activating enzyme 1
Names
A1S9T and BN75 temperature sensitivity complementing
POC20 centriolar protein homolog
UBA1, ubiquitin-activating enzyme E1 homolog A
testicular secretory protein Li 63
NP_003325.2
NP_695012.1
XP_005272706.1
XP_011542256.1
XP_016885266.1
XP_016885267.1
XP_016885268.1
XP_016885269.1
XP_016885270.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_009161.1 RefSeqGene

    Range
    5048..29329
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003334.4NP_003325.2  ubiquitin-like modifier-activating enzyme 1

    See identical proteins and their annotated locations for NP_003325.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC013041, BI547207, M58028
    Consensus CDS
    CCDS14275.1
    UniProtKB/Swiss-Prot
    P22314
    UniProtKB/TrEMBL
    A0A024R1A3
    Related
    ENSP00000338413.6, ENST00000335972.11
    Conserved Domains (4) summary
    cd01490
    Location:4701011
    Ube1_repeat2; Ubiquitin activating enzyme (E1), repeat 2. E1, a highly conserved small protein present universally in eukaryotic cells, is part of cascade to attach ubiquitin (Ub) covalently to substrate proteins. This cascade consists of activating (E1), conjugating ...
    cd01491
    Location:54436
    Ube1_repeat1; Ubiquitin activating enzyme (E1), repeat 1. E1, a highly conserved small protein present universally in eukaryotic cells, is part of cascade to attach ubiquitin (Ub) covalently to substrate proteins. This cascade consists of activating (E1), conjugating ...
    TIGR01408
    Location:491055
    Ube1; ubiquitin-activating enzyme E1
    pfam16191
    Location:302366
    E1_4HB; Ubiquitin-activating enzyme E1 four-helix bundle
  2. NM_153280.3NP_695012.1  ubiquitin-like modifier-activating enzyme 1

    See identical proteins and their annotated locations for NP_695012.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC013041, BG703038
    Consensus CDS
    CCDS14275.1
    UniProtKB/Swiss-Prot
    P22314
    UniProtKB/TrEMBL
    A0A024R1A3
    Related
    ENSP00000366568.4, ENST00000377351.8
    Conserved Domains (4) summary
    cd01490
    Location:4701011
    Ube1_repeat2; Ubiquitin activating enzyme (E1), repeat 2. E1, a highly conserved small protein present universally in eukaryotic cells, is part of cascade to attach ubiquitin (Ub) covalently to substrate proteins. This cascade consists of activating (E1), conjugating ...
    cd01491
    Location:54436
    Ube1_repeat1; Ubiquitin activating enzyme (E1), repeat 1. E1, a highly conserved small protein present universally in eukaryotic cells, is part of cascade to attach ubiquitin (Ub) covalently to substrate proteins. This cascade consists of activating (E1), conjugating ...
    TIGR01408
    Location:491055
    Ube1; ubiquitin-activating enzyme E1
    pfam16191
    Location:302366
    E1_4HB; Ubiquitin-activating enzyme E1 four-helix bundle

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    47190847..47215128
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005272649.1XP_005272706.1  ubiquitin-like modifier-activating enzyme 1 isoform X4

    See identical proteins and their annotated locations for XP_005272706.1

    Conserved Domains (4) summary
    cd01490
    Location:4761017
    Ube1_repeat2; Ubiquitin activating enzyme (E1), repeat 2. E1, a highly conserved small protein present universally in eukaryotic cells, is part of cascade to attach ubiquitin (Ub) covalently to substrate proteins. This cascade consists of activating (E1), conjugating ...
    cd01491
    Location:60442
    Ube1_repeat1; Ubiquitin activating enzyme (E1), repeat 1. E1, a highly conserved small protein present universally in eukaryotic cells, is part of cascade to attach ubiquitin (Ub) covalently to substrate proteins. This cascade consists of activating (E1), conjugating ...
    TIGR01408
    Location:551061
    Ube1; ubiquitin-activating enzyme E1
    pfam16191
    Location:308372
    E1_4HB; Ubiquitin-activating enzyme E1 four-helix bundle
  2. XM_011543954.2XP_011542256.1  ubiquitin-like modifier-activating enzyme 1 isoform X3

    Conserved Domains (4) summary
    cd01490
    Location:4841025
    Ube1_repeat2; Ubiquitin activating enzyme (E1), repeat 2. E1, a highly conserved small protein present universally in eukaryotic cells, is part of cascade to attach ubiquitin (Ub) covalently to substrate proteins. This cascade consists of activating (E1), conjugating ...
    cd01491
    Location:68450
    Ube1_repeat1; Ubiquitin activating enzyme (E1), repeat 1. E1, a highly conserved small protein present universally in eukaryotic cells, is part of cascade to attach ubiquitin (Ub) covalently to substrate proteins. This cascade consists of activating (E1), conjugating ...
    TIGR01408
    Location:631069
    Ube1; ubiquitin-activating enzyme E1
    pfam16191
    Location:316380
    E1_4HB; Ubiquitin-activating enzyme E1 four-helix bundle
  3. XM_017029779.2XP_016885268.1  ubiquitin-like modifier-activating enzyme 1 isoform X4

    Conserved Domains (4) summary
    cd01490
    Location:4761017
    Ube1_repeat2; Ubiquitin activating enzyme (E1), repeat 2. E1, a highly conserved small protein present universally in eukaryotic cells, is part of cascade to attach ubiquitin (Ub) covalently to substrate proteins. This cascade consists of activating (E1), conjugating ...
    cd01491
    Location:60442
    Ube1_repeat1; Ubiquitin activating enzyme (E1), repeat 1. E1, a highly conserved small protein present universally in eukaryotic cells, is part of cascade to attach ubiquitin (Ub) covalently to substrate proteins. This cascade consists of activating (E1), conjugating ...
    TIGR01408
    Location:551061
    Ube1; ubiquitin-activating enzyme E1
    pfam16191
    Location:308372
    E1_4HB; Ubiquitin-activating enzyme E1 four-helix bundle
  4. XM_017029778.2XP_016885267.1  ubiquitin-like modifier-activating enzyme 1 isoform X2

    Conserved Domains (4) summary
    cd01490
    Location:4981039
    Ube1_repeat2; Ubiquitin activating enzyme (E1), repeat 2. E1, a highly conserved small protein present universally in eukaryotic cells, is part of cascade to attach ubiquitin (Ub) covalently to substrate proteins. This cascade consists of activating (E1), conjugating ...
    cd01491
    Location:82464
    Ube1_repeat1; Ubiquitin activating enzyme (E1), repeat 1. E1, a highly conserved small protein present universally in eukaryotic cells, is part of cascade to attach ubiquitin (Ub) covalently to substrate proteins. This cascade consists of activating (E1), conjugating ...
    TIGR01408
    Location:771083
    Ube1; ubiquitin-activating enzyme E1
    pfam16191
    Location:330394
    E1_4HB; Ubiquitin-activating enzyme E1 four-helix bundle
  5. XM_017029780.1XP_016885269.1  ubiquitin-like modifier-activating enzyme 1 isoform X5

    UniProtKB/Swiss-Prot
    P22314
    UniProtKB/TrEMBL
    A0A024R1A3
    Conserved Domains (4) summary
    cd01490
    Location:4701011
    Ube1_repeat2; Ubiquitin activating enzyme (E1), repeat 2. E1, a highly conserved small protein present universally in eukaryotic cells, is part of cascade to attach ubiquitin (Ub) covalently to substrate proteins. This cascade consists of activating (E1), conjugating ...
    cd01491
    Location:54436
    Ube1_repeat1; Ubiquitin activating enzyme (E1), repeat 1. E1, a highly conserved small protein present universally in eukaryotic cells, is part of cascade to attach ubiquitin (Ub) covalently to substrate proteins. This cascade consists of activating (E1), conjugating ...
    TIGR01408
    Location:491055
    Ube1; ubiquitin-activating enzyme E1
    pfam16191
    Location:302366
    E1_4HB; Ubiquitin-activating enzyme E1 four-helix bundle
  6. XM_017029777.1XP_016885266.1  ubiquitin-like modifier-activating enzyme 1 isoform X1

  7. XM_017029781.1XP_016885270.1  ubiquitin-like modifier-activating enzyme 1 isoform X5

    UniProtKB/Swiss-Prot
    P22314
    UniProtKB/TrEMBL
    A0A024R1A3
    Conserved Domains (4) summary
    cd01490
    Location:4701011
    Ube1_repeat2; Ubiquitin activating enzyme (E1), repeat 2. E1, a highly conserved small protein present universally in eukaryotic cells, is part of cascade to attach ubiquitin (Ub) covalently to substrate proteins. This cascade consists of activating (E1), conjugating ...
    cd01491
    Location:54436
    Ube1_repeat1; Ubiquitin activating enzyme (E1), repeat 1. E1, a highly conserved small protein present universally in eukaryotic cells, is part of cascade to attach ubiquitin (Ub) covalently to substrate proteins. This cascade consists of activating (E1), conjugating ...
    TIGR01408
    Location:491055
    Ube1; ubiquitin-activating enzyme E1
    pfam16191
    Location:302366
    E1_4HB; Ubiquitin-activating enzyme E1 four-helix bundle
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