U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Clec4a3 C-type lectin domain family 4, member a3 [ Mus musculus (house mouse) ]

Gene ID: 73149, updated on 8-Feb-2024

Summary

Official Symbol
Clec4a3provided by MGI
Official Full Name
C-type lectin domain family 4, member a3provided by MGI
Primary source
MGI:MGI:1920399
See related
Ensembl:ENSMUSG00000043832 AllianceGenome:MGI:1920399
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dcir3; 3110037K17Rik
Summary
Predicted to enable calcium ion binding activity and mannose binding activity. Predicted to be involved in several processes, including antifungal innate immune response; negative regulation of tumor necrosis factor production; and plasmacytoid dendritic cell antigen processing and presentation. Predicted to be active in external side of plasma membrane. Orthologous to human CLEC4A (C-type lectin domain family 4 member A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 1.7), mammary gland adult (RPKM 1.6) and 19 other tissues See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Clec4a3 in Genome Data Viewer
Location:
6 F2; 6 58.04 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (122929474..122946837)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (122952515..122969878)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene 5316 Neighboring gene C-type lectin domain family 4, member a1 Neighboring gene STARR-seq mESC enhancer starr_17264 Neighboring gene C-type lectin domain family 4, member a4 Neighboring gene STARR-seq mESC enhancer starr_17268 Neighboring gene STARR-seq mESC enhancer starr_17269 Neighboring gene C-type lectin domain family 4, member b1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables carbohydrate binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables carbohydrate binding ISO
Inferred from Sequence Orthology
more info
 
enables mannose binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in antifungal innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
dendritic cell inhibitory receptor 3

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204241.1NP_001191170.1  dendritic cell inhibitory receptor 3

    See identical proteins and their annotated locations for NP_001191170.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC034893
    Consensus CDS
    CCDS20508.1
    UniProtKB/TrEMBL
    Q5YIR7, Q8JZX6
    Related
    ENSMUSP00000112716.2, ENSMUST00000117173.8
    Conserved Domains (2) summary
    cd03590
    Location:107230
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
    pfam10332
    Location:4182
    DUF2418; Protein of unknown function (DUF2418)
  2. NM_153197.4NP_694877.2  dendritic cell inhibitory receptor 3

    See identical proteins and their annotated locations for NP_694877.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK156040, BC034893
    Consensus CDS
    CCDS20508.1
    UniProtKB/TrEMBL
    Q5YIR7, Q8JZX6
    Related
    ENSMUSP00000085816.5, ENSMUST00000088468.7
    Conserved Domains (2) summary
    cd03590
    Location:107230
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
    pfam10332
    Location:4182
    DUF2418; Protein of unknown function (DUF2418)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    122929474..122946837
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)